Results 91 to 100 of about 149 (147)

The molecular basis of lactase persistence: Linking genetics and epigenetics

Annals of Human Genetics, EarlyView.
Abstract Lactase persistence (LP) — the genetic trait that determines the continued expression of the enzyme lactase into adulthood — has undergone recent, rapid positive selection since the advent of animal domestication and dairying in some human populations.
Céleste E. Cohen, Dallas M. Swallow, Catherine Walker   +2 more
wiley   +1 more source

Klotho Regulates Club Cell Senescence and Differentiation in Chronic Obstructive Pulmonary Disease

Cell Proliferation, EarlyView.
We speculated lack of Klotho (KL) would aggravate club cell senescence, which contributes to COPD inflammation. In this study, we collected chronic obstructive pulmonary disease (COPD) lung tissue using single‐cell RNA sequencing (scRNA‐seq), revealing club cell heterogeneity and cellular senescence in COPD.
Min Li, Bo Chen, Sibo Sun, Kai Wang, Yu Wang, Jianqing Wu   +5 more
wiley   +1 more source

Studies on .BETA.-galactosidase. II. Purificaof .BETA.-of .BETA.-galactosidase from Macrophomina phaseoli and its enzymatic properties.

Chemical and Pharmaceutical Bulletin, 1976
Mamoru Sugiura, Mutsuko Suzuki, Tokiko Shimomura, Masanori Sasaki   +3 more
openaire   +4 more sources

Mitochondrial Mutation Leads to Cardiomyocyte Hypertrophy by Disruption of Mitochondria‐Associated ER Membrane

Cell Proliferation, EarlyView.
Cardiomyocytes with high m.3243A>G burden exhibited hypertrophic phenotype. Mitochondria dysfunction occurred and tended to become round in cardiomyocytes with high m.3243A>G burden. Mitochondria‐associated ER membrane (MAM) was disrupted in cardiomyocytes with high m.3243A>G burden.
Miao Yu, Min Song, Manna Zhang, Shuangshuang Chen, Baoqiang Ni, Xuechun Li, Wei Lei, Zhenya Shen, Yong Fan, Jianyi Zhang, Shijun Hu   +10 more
wiley   +1 more source

Saccharomyces cerevisiae Mub1, a substrate adaptor of E3 ubiquitin ligase Ubr2, modulates sensitivity to cell wall stressors through multiple transcription factors

The FEBS Journal, EarlyView.
We show that Mub1 links cell wall robustness with the ubiquitin‐proteasome system. As an adaptor protein of the E3 ubiquitin ligase Ubr2, it facilitates the ubiquitination of various transcription factors, including Mcm1 and Swi4. Yeasts evolved a complex regulatory programme to build and maintain their cell wall, the primary structure through which ...
Nada Šupljika, Antonia Paić, Ana Novačić, Tea Martinić Cezar, Béatrice Vallée, Renata Teparić, Igor Stuparević, Bojan Žunar   +7 more
wiley   +1 more source

Protective effects of Paeonia suffruticosa callus extract in skin through anti‐inflammation and repair UVB‐induced damage

International Journal of Cosmetic Science, EarlyView.
Peony callus extract (PCE) is beneficial for skin anti‐ageing and sensitivity induced by UVB radiation, through decreasing the level of inflammatory factors and matrix metalloproteinases. Furthermore, our research indicates that PCE effectively improves the total collagen content in human skin. Abstract Objective The study investigated effects of peony
Yufan Li, Jiejun Han, Rongyue Gong, Yuankun Liu, Yu Zhou, Tiangui Gong, Bin Wang, Laidi Zhang, Shuodan Li, Jiayue Chen   +9 more
wiley   +1 more source

The human colon: Evidence for degenerative changes during aging and the physiological consequences

Neurogastroenterology &Motility, EarlyView.
Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley   +1 more source

Mass spectrometry reveals age‐dependent collagen decline in murine atria

Annals of the New York Academy of Sciences, EarlyView.
Using mass spectrometry, we analyzed the atrial ECM of young (12 weeks) and old (77 weeks) C57BL/6J mice. Results showed a marked decrease in collagen content with age, alongside increases in specific ECM‐related proteins (e.g., MMP9, S100A9, VWA3A).
Nathalie Ringström, Charlotte Edling, Giovanna Nalesso, Javier Barallobre‐Barreiro, Kamalan Jeevaratnam   +4 more
wiley   +1 more source

Porphyromonas gingivalis GroEL exacerbates orthotopic allograft transplantation vasculopathy via impairment of endothelial cell function

Molecular Oral Microbiology, EarlyView.
Abstract Orthotopic allograft transplantation (OAT) is a significant approach to addressing organ failure. However, persistent immune responses to the allograft affect chronic rejection, which induces OAT vasculopathy (OATV) and organ failure. Porphyromonas gingivalis can infiltrate remote organs via the bloodstream, thereby intensifying the severity ...
Chien‐Sung Tsai, Chun‐Yao Huang, Yi‐Ting Tsai, Chun‐Ming Shih, Ze‐Hao Lai, Chen‐Wei Liu, Yi‐Wen Lin, Feng‐Yen Lin   +7 more
wiley   +1 more source

A large‐scale gene regulatory network for rice endosperm starch biosynthesis and its application in genetic improvement of rice quality

Plant Biotechnology Journal, EarlyView.
Summary Rice (Oryza sativa L.) is one of the most important food crops. Starch is the main substance of rice endosperm and largely determines the grain quality and yield. Starch biosynthesis in endosperm is very complex, requiring a series of enzymes which are also regulated by many transcription factors (TFs). But until now, the large‐scale regulatory
Kunyong Huang, Feifei Lu, Pengfei Chen, Guiai Jiao, Haiyan Lin, Jian Zhang, Shaolu Zhao, Ruijie Cao, Gaoneng Shao, Zhonghua Sheng, Shikai Hu, Shaoqing Tang, Peisong Hu, Xiangjin Wei   +13 more
wiley   +1 more source