Results 121 to 130 of about 149 (147)

Serum metabolic and microbial profiling yields insights into promoting effect of tryptophan‐related metabolites for health longevity in centenarians

iMeta, Volume 4, Issue 3, June 2025.
Schematic representation of the design. Tryptophan metabolism is enriched in serum metabolites and gut microbiota of centenarians, potentially contributing to healthy longevity. A key tryptophan metabolite 5‐methoxyindoleacetic acid (5‐MIAA) is linked to the Christensenellaceae R‐7 group and exhibits effects of delaying cell senescence, promoting ...
Xiaorou Qiu, Chao Mu, Jie Hu, Jiaxin Yu, Wenbo Tang, Yueli Liu, Yongmei Huang, Yixian Lu, Peihua Tang, Jingzhen Wu, Zixuan Huang, Xianlin Mei, Huaguo Xiang, Hao Lin, Yi Qi, Hui Luo, Xuemeng Li   +16 more
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Beta-Galactosidase of Helix pomatia

Nature, 1964
THE digestive juice of Helix pomatia contains a remarkable number of enzymes; many of them are carbohydrases, and they include an enzyme that hydrolyses lactose or β-methyl-galactoside1,2. This communication describes the properties and activities of the enzyme that hydrolyses o-nitrophenyl-β-D-galactopyranoside (ONPG).
Got R, A Marnay, P Jarrige, J Font
openaire   +3 more sources

The discovery of β-galactosidase

Trends in Biochemical Sciences, 1989
The enzyme beta-galactosidase was first mentioned in the literature by Beijerinck exactly a hundred years ago. The Department of Microbiology and Enzymology of the Delft University of Technology keeps the memory of Beijerinck, its first professor, alive by maintaining a 'Beijerinck-room' in the attic of the building.
Rouwenhorst, R.J. (author), Pronk, J.T. (author), Van Dijken, J.P. (author)   +2 more
openaire   +4 more sources

Beta-Galactosidase Deficiency in the Hurler Syndrome

New England Journal of Medicine, 1969
Abstract A deficiency of β-galactosidase (pH 5.0) was found in frozen tissues (brain, liver, kidney and spleen) from 10 patients with Hurler's syndrome (Types 1–3). The diminished activity of this enzyme was demonstrated with the use of nitrophenyl-galactosides as well as ganglioside GM1 and a "keratan sulfate-like" mucopolysaccharide.
Mae Wan Ho, Al L. Tappel, Monica C. MacBrinn, Vimal Patel, Shintaro Okada, John S. O'Brien, Marjorie Woollacott   +6 more
openaire   +3 more sources

Immobilization of mold beta-galactosidase

Collection of Czechoslovak Chemical Communications, 1988
We immobilized beta-galactosidase (EC 3.2.1.23) from the mold Aspergillus oryzae by various methods on the derivatives of bead cellulose manufactured by Czechoslovak industry. The activity, specific activity and operational stability of the immobilized enzyme were determined.
Alexandra Proskova, Milena Kminkova, Jiří Kučera   +2 more
openaire   +2 more sources

Beta-Galactosidase Staining in the Skeleton

2014
The lacZ gene, encoding for the β-galactosidase enzyme, is widely used as a reporter gene in bone biology due to the ease of visualization in situ on whole-mount or on tissue sections. In this protocol we provide detailed methods for visualizing this reporter gene for both in vivo and in vitro studies.
Jian Q. Feng, X. L. Han
openaire   +3 more sources

Generalized Gangliosidosis: Beta-Galactosidase Deficiency

Science, 1968
A profound deficiency (10- to 30-fold) of β-galactosidase activity was found in tissues (liver, spleen, kidney, and brain) from two patients with generalized gangliosidosis; this deficiency is demonstrated as a failure to cleave both p -nitrophenyl-β-D-galactopyranoside and ganglioside GM 1 ...
Shintaro Okada, John S. O'Brien
openaire   +3 more sources

Three cases of beta-galactosidase deficiency

Klinische Pädiatrie, 1981
A clinical description of three cases of beta-galactosidase deficiency is presented. Two cases are classical for infant type GM1-gangliosidosis, the third is characterised by dysostosis multiplex with growth retardation and of normal intelligence. Laboratory data revealed mucopolysaccharides in the urine of all described patients in a high level of ...
Ewa Pronicka, Barbara Czartoryska, Danuta Górska, Anna Tylki   +3 more
openaire   +3 more sources

Human lysosomal .beta.-galactosidase-cathepsin A complex: Definition of the .beta.-galactosidase-binding interface on cathepsin A

Biochemistry, 1995
Human lysosomal beta-galactosidase is organized as a 680-kDa complex with cathepsin A (also named carboxypeptidase L and protective protein), which is necessary to protect beta-galactosidase from intralysosomal proteolysis. To understand the molecular mechanism of beta-galactosidase protection by cathepsin A, we defined the structural organization of ...
Marc-André Elsliger, Alexey V. Pshezhetsky, Michel Potier, Maya V. Vinogradova   +3 more
openaire   +3 more sources

A dimer-dimer binding region in .beta.-galactosidase

Biochemistry, 1979
alpha Complementation in beta-galactosidase is the restoration of enzyme activity by addition of the alpha donor CNBr2, from amino acid residues 3--92 of the polypeptide, to inactive M15 protein from the lacZ deletion mutant strain M15. M15 protein lacks residues 11--41 and is a dimer; the active complex, like native beta-galactosidase, is tetrameric ...
Irving Zabin, Franco Celada
openaire   +3 more sources