Results 41 to 50 of about 149 (147)

EGFR‐TKIs Induced DPP4 Drives Metabolic Reprogramming of Persister Cells in Lung Cancer

Advanced Science, EarlyView.
Drug‐tolerant persister (DTP) cells emerge early during EGFR‐TKI treatment, preceding the development of acquired resistance. Elevated DPP4 in DTP cells drives metabolic reprogramming and antioxidant adaptation, promoting cell survival under drug pressure.
Yuanzhou Zhang, Xiaojun Zhang, Xupeng Yang, Xingshi Chen, Yuehong Wang, Jingying Hu, Rui Liu, Xiaoying Luo   +7 more
wiley   +1 more source

Isolation and characterization of jack bean beta-galactosidase.

Journal of Biological Chemistry, 1975
A simple procedure has been devised to isolate beta-galactosidase from jack bean meal. The final preparation gives one major protein banc in disc gel electrophoresis. The substrate specificity of this enzyme toward some natural oligosaccharides, glycoproteins, and sphingoglycolipids has been examined in detail.
S C Li, Mary Y. Mazzotta, S F Chien, Y T Li   +3 more
openaire   +2 more sources

Recent Advances in Cancer Cell Membrane‐Based Nanoparticles and Cancer Cell‐Derived Small Extracellular Vesicles as Drug Delivery Platforms

Advanced NanoBiomed Research, EarlyView.
Cancer cell membrane‐based nanoparticles (CCM‐NPs) and cancer cell‐derived small extracellular vesicles (CsEVs) are emerging as promising drug delivery systems for targeted cancer treatment. Advances in nanotechnology have paved the way for innovative drug delivery systems that enhance the effectiveness of cancer treatment.
Wei Zhang, Jingjing Wang, Long Ngo, Li Li, Yuling Wang   +4 more
wiley   +1 more source

Solid‐state fermentation pro‐enzymes supplementation benefits growth performance, health, and intestinal microbiota of broiler chickens fed wheat‐based diet

Animal Research and One Health, EarlyView.
Wheat as a kind of diet material can be used for broiler production. However, due to non‐starch polysaccharides (NSP) in wheat, wheat may lead to lower growth performance and worth health. This experiment used solid‐state fermentation pro‐enzymes (SFP enzymes) to reverse the negative effect of wheat.
Jiaheng Li, Guosong Bai, Yan Gao, Qingtao Gao, Ruqing Zhong, Liang Chen, Yunlong Wang, Teng Ma, Hongfu Zhang   +8 more
wiley   +1 more source

Noncoding RNAs in Host–Microbiota Interaction

Animal Research and One Health, EarlyView.
The intricate interplay between gut microbiota and the host exerts a profound impact on host biological processes and disease development. This review highlights the pivotal role of noncoding RNAs (ncRNAs) in this interaction. Host ncRNAs regulate gene expression and microbiota composition, whereas microbial small RNAs (sRNAs) modulate host gene ...
Ziyi Zhao, Ni Li, Jingyi Xu, Jianrong Ren, Xiaojun Yang, Xinyi Li, Junhu Yao, Shengru Wu   +7 more
wiley   +1 more source

Beta-Galactosidase-Producing Thermophilic Bacterium, Thermus thermophilus KNOUC114: Identification of the Bacterium, Gene and Properties of Beta-Galactosidase

International Journal of Biology, 2011
A Beta-galactosidase-producing bacterium, strain KNOUC114 isolated from a hot spring was identified, and its gene of Beta-galactosidase and properties of the enzyme were studied. The strain KNOUC114 showed typical properties of genus Thermus with phenotypic characteristics of rod-shape (0.2x3.5 um), Gram negative, non-motile, endospore not observed ...
Jong Kun Ahn, Hyun Bong Choi, Jeong Hyun Lim, Hyunjin Park, Eun Sook Nam   +4 more
openaire   +2 more sources

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

Advances in Cytosolic Delivery of Proteins: Approaches, Challenges, and Emerging Technologies

Chemistry &Biodiversity, EarlyView.
Proteins regulate almost all biological processes, and overcoming the protein's natural membrane inpermeability will provide a unique opportunity for intracellular targeting of related therapeutic proteins. Chemical modification of proteins and different types of delivery vectors can mediate intracellular transport of proteins, providing new ideas for ...
Wenyan Zhang, Huiling Liu, Bingdong Zhu, Wen Li, Xue Han, Jiaojiao Fu, Renjie Luo, Haiyan Wang, Jinxia Wang   +8 more
wiley   +1 more source

Fisetin as a Blueprint for Senotherapeutic Agents – Elucidating Geroprotective and Senolytic Properties with Molecular Modeling

Chemistry – A European Journal, Volume 31, Issue 16, March 17, 2025.
The exceptional senotherapeutic activity of fisetin, combining both geroprotective and senolytic effects, was validated using computational chemistry tools, establishing it as a cornerstone template for the development of novel agents. Abstract Targeting senescent cells and the factors that accelerate this pathological state has recently emerged as a ...
Maciej Spiegel
wiley   +1 more source

Valorization of Apple Pomace: Production of Phloretin Using a Bacterial Cellulose‐Immobilized β‐Glycosidase

ChemSusChem, EarlyView.
This study presents a whole valorization of apple processing waste: phloretin is efficiently produced from phloridzin (abundantly found in apple residues), using a β‐glycosidase immobilized on bacterial cellulose in a biphasic system. Notably, bacterial cellulose is derived from fermentation of apple pomace sugars, making both the enzyme carrier and ...
Agostina Colacicco, Luca Nespoli, Emma Ribul Moro, Stefano Farris, Francesco Molinari, Diego Romano, Martina Letizia Contente   +6 more
wiley   +1 more source