Results 51 to 60 of about 149 (147)

Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration

International Journal of Cancer, EarlyView.
What's New? SOX2 is one of the key developmental genes with a reported altered expression in many tumors. The mechanisms underlying SOX2 regulation in cancer, however, remain elusive. This study shows that TP53 transcriptionally regulates SOX2 through binding to its promoter and the SRR2 enhancer.
Patricia Lado‐Fernández, Jéssica M. Vilas, Tânia Fernandes, Carmen Carneiro, Sabela Da Silva‐Álvarez, Valentín Estévez‐Souto, Pablo Pedrosa, Miguel González‐Barcia, Luis E. Abatti, Jennifer A. Mitchell, Carmen Rivas, Gema Moreno‐Bueno, Anxo Vidal, Manuel Collado   +13 more
wiley   +1 more source

Construction of Reporter Phage T4::Nluc and Its Application in the Detection of Escherichia coli in Urinary Tract Infections

iLABMED, EarlyView.
A reporter phage T4::Nluc was constructed using the CRISPR/Cas9 system combined with homologous recombination and was applied for the detection of clinical Escherichia coli in urinary tract infections (UTIs). T4::Nluc exhibited superior sensitivity and specificity, and had a short detection time, making it a powerful tool for diagnosing UTIs.
Zhiyun Hao, Minwei Li, Qiang Zhao, Liye Wang, Ting Liu, Chi Wang, Chengbin Wang   +6 more
wiley   +1 more source

Maternal gut microbiota‐derived daidzein prevents osteoporosis in female offspring following prenatal prednisone exposure

iMeta, EarlyView.
Prenatal prednisone therapy (PPT)/prenatal prednisone exposure (PPE) induces long bone dysplasia, reduced peak bone mass (PBM), and increased osteoporosis susceptibility in female offspring. Maternal gut microbiota metabolite daidzein (DAI) mediates PPE‐induced osteoporosis susceptibility in female adult offspring.
Chi Ma, Hangyuan He, Kunpeng Wang, Juanjuan Guo, Liang Liu, Yuting Chen, Bin Li, Hao Xiao, Xufeng Li, Xiaoqian Lu, Tingting Wang, Yinxian Wen, Hui Wang, Liaobin Chen   +13 more
wiley   +1 more source

Synthetic biology for medical biomaterials

Interdisciplinary Medicine, EarlyView.
Synthetic biology platform has been utilized to produce a variety of medical biomaterials (MBMs), such as polylactic acid (PLA), polyhydroxyalkanoates (PHAs), hyaluronic acid (HA), collagen (COL), poly(β‐malic acid) (PMLA), poly‐γ‐glutamic acid (γ‐PGA), alginate (ALG), chitosan (CS), bacterial cellulose (BC), and antimicrobial peptides (AMPs).
Tao Xu, Xiao‐Yun Huang, Jin‐Wei Dao, Da Xiao, Dai‐Xu Wei   +4 more
wiley   +1 more source

Characterization of Silver Nanoparticles Synthesized Using Hypericum perforatum L. and Their Effects on Staphylococcus aureus

Microscopy Research and Technique, EarlyView.
This study investigated the effects of biosynthesized silver nanoparticles (AgNPs) derived from Hypericum perforatum on the cell morphology of Gram‐positive Staphylococcus aureus bacterial cells, with FE‐SEM analysis showing distinct morphological changes in AgNP‐treated S. aureus cells compared to the control group.
Canan Sevinc‐Sasmaz, Fatih Erci, Emrah Torlak, Mustafa Yöntem   +3 more
wiley   +1 more source

Nongenetic heterogeneity of mouse beta-galactosidase. [PDF]

Journal of Biological Chemistry, 1977
Lusis, A J, Breen, G A, Paigen, K
openaire   +2 more sources

Heterogeneity of Intratumoral Microbiota Within the Tumor Microenvironment and Relationship to Tumor Development

Med Research, EarlyView.
Mutual shaping of tumor microbiota and TME. Intratumoral microbiota—comprising diverse bacteria, fungi, viruses, and intracellular organisms—play critical and dynamic roles in shaping the tumor microenvironment (TME). Their spatial and compositional diversity contributes to both intratumoral and intertumoral heterogeneity, influencing immune modulation
Zhifei Gao, Aimin Jiang, Zizhuo Li, Lingxuan Zhu, Weiming Mou, Weitao Shen, Peng Luo, Bufu Tang, Jian Zhang, Anqi Lin   +9 more
wiley   +1 more source

Fecal Metaproteomics as a Tool to Monitor Functional Modifications Induced in the Gut Microbiota by Ketogenic Diet: A Case Study

PROTEOMICS, EarlyView.
ABSTRACT Metaproteomics is a valuable approach to characterize the biological functions involved in the gut microbiota (GM) response to dietary interventions. Ketogenic diets (KDs) are very effective in controlling seizure severity and frequency in drug‐resistant epilepsy (DRE) and in the weight loss management in obese/overweight individuals.
Alessandro Tanca, Simona Masia, Piero Giustacchini, Sergio Uzzau   +3 more
wiley   +1 more source

Heart failure in two male patients with late‐onset Fabry mutation (IVS4 + 919G > A)

ESC Heart Failure, Volume 12, Issue 2, Page 1508-1513, April 2025.
Xufei Yang, Chunlan Deng, Xiaogang Guo, Hui Yan   +3 more
wiley   +1 more source

Tethered Catalytic Hairpin Assembly with Plasmon‐Enhanced Fluorescence Readout for Single Molecule Detection

Small Methods, EarlyView.
This work presents a single‐molecule detection platform that does not rely on the partitioning of analyzed liquid samples and on enzymatic amplification of fluorescence signals. A flexible polymer linker serves to spatially confine catalytic‐harpin assembly‐based DNA amplification.
Naoto Asai, Katharina Schmidt, Gizem Aktuğ, Stefan Fossati, Juraj Sladek, N. Scott Lynn Jr., Jakub Dostalek   +6 more
wiley   +1 more source