Results 61 to 70 of about 149 (147)
Small Structures, EarlyView.This study successfully develops an injectable, dual‐function nanocomposite hydrogel comprising kartogenin‐loaded aminated hollow mesoporous Prussian blue (NH2‐HMPB) nanozyme (termed NH@K nanozyme) and hyaluronic acid methacrylate (HAMA). NH@K nanozyme rejuvenates the senescent microenvironment by scavenging reactive oxygen species and inhibiting ...
Shu‐Hang He +10 more
wiley +1 more source
VIEW, EarlyView.Our findings demonstrate that NAD+ metabolism dysregulation contributes to elevated intraocular pressure in glaucoma. Supplementation with NAD+ precursors reduces IOP by alleviating oxidative stress, cellular senescence, and extracellular matrix deposition.
Youjia Zhang +10 more
wiley +1 more source
Annals of Applied Biology, EarlyView.The forage digestibility decreases in the dry season. Fungus isolates from the gastrointestinal tract of healthy sheep were evaluated. Aspergillus terreus isolate was identified by analysis of rDNA and encoding β‐tubulin gene and Trichoderma longibrachiatum was identified by analysis of rDNA and elongation factor 1‐α gene. The T.
Claudio Eduardo Silva Freitas +10 more
wiley +1 more source
Aging Cell, EarlyView.Larvae derived from a cross between tert deficient and haploinsufficient fish show a premature aging phenotype, characterized by telomere attrition and early death. The ST2 larval model is a valuable tool for rapid screening of antiaging molecules. Given that organogenesis occurs within the first 48 h, this model also allows for the conduction of aging
David Hernández‐Silva +5 more
wiley +1 more source
Rejuvenation of Senescent Cells, In Vitro and In Vivo, by Low‐Frequency Ultrasound
Aging Cell, EarlyView.Optimized low‐frequency ultrasound rejuvenates induced senescent cells and aged mice. Our results show that LFU reverses 15 aspects of senescent cells including growth and revitalizes aged mice. ABSTRACT The presence of senescent cells causes age‐related pathologies since their removal by genetic or pharmacological means, as well as possibly by ...
Sanjay K. Kureel +8 more
wiley +1 more source
Circular RNA Telomerase Reverses Endothelial Senescence in Progeria
Aging Cell, EarlyView.TERT circRNA outperforms linear TERT mRNA in reversing the hallmarks of senescence. TERT circRNA more efficiently restores endothelial function and shows superior capability in enhancing mitochondrial function. ABSTRACT Telomeres shorten with each cell division, acting as a chronometer of cell age. The enzyme telomerase, primarily active in stem cells,
Weifeng Qin +6 more
wiley +1 more source
Beta-galactosidase activity assay for yeast [PDF]
Protocol Exchange, 2019 Carmen Bano +3 more
openaire +2 more sources
Deciphering the Contribution of Circular RNAs to Age‐Related Decline in Sertoli Cell Survivor
Aging Cell, EarlyView.Sertoli cell survival is regulated by circAbcb9‐ceRNET. Physiologically, the circAbcb9 sponge activity toward miR‐214‐3p ensures the expression of SOX8 and NOTCH2 targets, both crucial in maintaining SC homeostasis. The aging process negatively affects FUS‐dependent backsplicing activity in Sertoli cells leading to circAbcb9 downregulation, and in turn,
Francesco Manfrevola +11 more
wiley +1 more source
Aging Cell, EarlyView.UVB exposure can trigger senescence in dermal fibroblasts. We show that silencing ATF6α disrupts the establishment of the UVB‐induced senescent phenotype by preventing the onset of several senescent biomarkers and altering the composition of the SASP, consequently affecting its impact on the skin microenvironment.
Joëlle Giroud +19 more
wiley +1 more source
Diabetes Advances Cardiomyocyte Senescence Through Interfering Rnd3 Expression and Function
Aging Cell, EarlyView.Diabetes‐induced upregulation of miR‐103a‐3p suppresses Rnd3 expression in cardiomyocytes, thereby promoting the senescence‐associated secretory phenotype (SASP) through activation of the STAT3 signaling pathway, mediated by UPS‐induced degradation of p‐STAT3.
Linxu Wu +16 more
wiley +1 more source