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Beta-Hydroxybutyrate: A Supplemental Molecule for Various Diseases
Current Drug Targets: β-hydroxybutyrate (BHB) is a ketone body that serves as an alternative energy source for various tissues, including the brain, heart, and skeletal muscle. As a metabolic intermediate and signaling molecule, BHB plays a crucial role in modulating cellular and physiological processes.
Navid Reza Shahtaghi +4 more
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Reversible modification of D-.beta.-hydroxybutyrate dehydrogenase by diamide
Biochemistry, 1984D-beta-Hydroxybutyrate dehydrogenase is a lipid-requiring enzyme with a specific requirement of lecithin for function. The purified enzyme devoid of lipid (apodehydrogenase) is inactive but can be reactivated by forming a complex with phospholipid containing lecithin.
E A, Fleer, J O, McIntyre, S, Fleischer
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A spectrophotometric micro-method for the enzymatic determination of beta-hydroxybutyrate
Clinica Chimica Acta, 1972Abstract A simple, spectrophotometric micro-method for the determination of D -β-hydro-xybutyrate is described. A study of the conditions of the reaction showed that the inclusion of hydrazine as an agent for trapping the acetoacetic acid formed in the reaction was obligatory. Product inhibition due to excess acetoacetate was noted in the absence of
A, Chandrasekaran +2 more
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Capillary beta-hydroxybutyrate determination for monitoring diabetic ketoacidosis
Endocrinología y Nutrición (English Edition), 2011Diabetic ketoacidosis (DKA) is the most severe acute metabolic complication of type 1 diabetes mellitus. Insulin treatment is commonly guided by plasma glucose levels and changes in venous blood gases, while β-hydroxibutyrate (BHB) levels are rarely measured.
Beatriz, Rodríguez-Merchán +8 more
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Effect of Beta‐hydroxybutyrate on Myoblast Proliferation and Differentiation
The FASEB Journal, 2019Ketogenic diets (KDs) and fasting have been promoted for weight loss and health. KDs cause an increase in circulating levels of ketone bodies, including beta‐hydroxybutyrate (βHB). The effects of amplified levels of βHB on skeletal muscle proliferation and differentiation are largely unknown. Therefore, we tested whether βHB has an
Joshua R. Melanson +4 more
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Postmortem Vitreous Beta‐Hydroxybutyrate: Interpretation in a Forensic Setting*
Journal of Forensic Sciences, 2012Abstract: Vitreous beta‐hydroxybutyrate (BHB) was retrospectively analyzed in 1795 forensic cases using the Pointe Scientific method. Comparison of vitreous BHB with vitreous glucose in 1781 of the cases showed moderately good correlation r = 0.731. Comparison with blood alcohol levels in 1561 of the cases showed no correlation r = −0.053.
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Beta-hydroxybutyrate transport in rat brain: developmental and dietary modulations
American Journal of Physiology-Legacy Content, 1976Transport of beta-hydroxybutyrate (betaHB) into rat brain was estimated from the early rise in brain/serum 14C ratio after subcutaneous injection of [14C]betaHB. Permeability of the D isomer exceeded that of the L isomer. Permeability of either isomer rose throughout suckling (sevenfold) and declined after weaning to the low, newborn values.
T J, Moore +3 more
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Effect of beta-hydroxybutyrate on lipid mobilization
American Journal of Physiology-Legacy Content, 1967P, Björntorp, T, Scherstén
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