Results 141 to 150 of about 89,494 (296)
Veterinary Record, EarlyView.Abstract Background Disease in primary care frequently represents a surveillance blind spot, particularly for diseases affecting farm animals. Methods Electronic health records (EHRs) were collected from four farm animal veterinary practices in Wales (February 2024‒January 2025) as part of a pilot study.
Beverley Hopkins +8 more
wiley +1 more source
Cefdinir binding to a class A β‐lactamase revealed by serial cryo‐crystallography
Acta Crystallographica Section D, EarlyView.Serial cryo‐crystallography reveals the structure of the extended‐spectrum β‐lactamase CTX‐M‐14 in complex with the third‐generation cephalosporin antibiotic cefdinir.One of the most common resistance mechanisms against antibiotics employed by Gram‐negative bacteria involves the production of β‐lactamases, resulting in rapid hydrolysis of the ...
Gargi Gore +4 more
wiley +1 more source
Dendrimeric Antigens for Passive Mast Cell Activation in the Evaluation of Amoxicillin Allergy
Allergy, EarlyView.DeAns with defined nanoscale structure reveal that conjugate size and determinant density govern IgE‐mediated effector‐cell activation in AX allergy. All DeAn generations bind to sIgE in inhibition immunoassay, but only larger DeAns trigger FcεRI‐dependent responses in mouse MC, huRBL‐2H3, and LUVA cells.
Amene Tesfaye Ayane +12 more
wiley +1 more source
Successful Application of the Mast Cell Activation Test in Immediate Hypersensitivity to Amoxicillin
Allergy, EarlyView.This study included 28 amoxicillin‐allergic patients and 11 healthy exposed controls. Mast cells were differentiated from CD34+ progenitors over 8 weeks using cytokine cocktails. The mast cell activation test involved sensitization with patient or control sera and stimulation with free amoxicillin or G4/G5‐AXO dendrimers with successfully activated ...
Jose A. Céspedes +11 more
wiley +1 more source
Hypersensitivity to Excipients in Drugs: An EAACI Position Paper
Allergy, EarlyView.ABSTRACT Drugs contain active pharmaceutical ingredients and excipients, compounds which enhance the pharmacokinetics, stability and palatability of the pharmaceutical formulation. While most drug hypersensitivity reactions (DHR) are caused by active ingredients, excipients may also be involved.
Lene H. Garvey +10 more
wiley +1 more source
Acta Paediatrica, EarlyView.ABSTRACT Aim To synthesise evidence on the effectiveness, harms and benefits of different approaches to prevent early‐onset Group B Streptococcus (EOGBS) and identify gaps in short and longer‐term outcomes. Methods A two‐phase rapid review. Phase 1 included an overview of systematic reviews (SRs).
Pauline Campbell +12 more
wiley +1 more source
Dilemmas of the Beta-Lactam Explosion [PDF]
Infection Control, 1981 P C, Fuchs, R N, Jones
openaire +2 more sources
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren +8 more
wiley +1 more source