Results 171 to 180 of about 637,109 (288)

Building a Beta-Lactam Model-Informed Precision Dosing Service in a Quaternary Care Children's Hospital. [PDF]

Clin Transl Sci
Tang Girdwood S, Morales Junior R, Schuler E, Tang P, Diseroad E, Misch C, Engle B, McCall S, Murphy ME, Taylor ZL, Mizuno T, Vinks AA, Kaplan J.   +12 more
europepmc   +1 more source

The Synergy Between a Silver‐Ruthenium Antimicrobial and Aminoglycosides Is Based on Severe Macromolecular Damage

Molecular Microbiology, EarlyView.
AGXX enhances aminoglycoside activity against multidrug‐resistant pathogens such as uropathogenic Escherichia coli by increasing reactive oxygen species, causing protein aggregation and DNA damage. This effect is reduced by oxygen limitation or antioxidants. Polyphosphate protects cells from oxidative damage.
Emmanuel P. Oladokun, Gracious Y. Donkor, Julius K. Narh, Grady D. Jacobson, Cade Ward, Patrick O. Tawiah, Lisa K. Polzer, Kevin A. Edwards, Kyle A. Floyd, Jan‐Ulrik Dahl   +9 more
wiley   +1 more source

Medication Exposure Definitions in Perinatal Pharmacoepidemiology: Implications for Pregnancy Studies

Paediatric and Perinatal Epidemiology, EarlyView.
ABSTRACT Background Exposure definitions in real‐world pregnancy studies vary across studies, data sources, treatments and outcomes, yet their impact on prevalence estimates remains unexamined. Objectives To identify the most used exposure definitions during the 1st trimester and evaluate their impact on prevalence estimates: Methods We reviewed 400 ...
Gabra Nohmie, Anick Bérard, Anton Pottegård, Mette Bliddal   +3 more
wiley   +1 more source

Comment on "evaluation of high dose post-dialytic versus daily beta-lactam dosing in hemodialysis patients using Monte Carlo simulation". [PDF]

Int J Clin Pharm
Aljumaa SA, Al Musawa M, El Lababidi R, Abidi E, Ghazi I, El Nekidy WS.   +5 more
europepmc   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

Beta-Lactam Plus Azithromycin or Doxycycline vs Fluoroquinolones in Adult Patients Hospitalized With Community-Acquired Pneumonia: A Systematic Review and Network Meta-analysis. [PDF]

Open Forum Infect Dis
Farah MH, Abusalih M, Farah W, El Labban M, Haydour Q, Ramachandran N, Wang Z, Barreto EF, Prokop L, Murad MH, Odeyemi Y.   +10 more
europepmc   +1 more source

Outcomes of a Routine Screening Protocol to Prevent Metamycoplasma and Ureaplasma Infection in Lung Transplant Recipients

Transplant Infectious Disease, EarlyView.
This study analyzed outcomes of an early Mollicute (Mycoplasma hominis and Ureaplasma spp.) screening protocol using BAL PCR with preemptive treatment and ammonia monitoring in lung transplant recipients. This appears to be a practical and reasonably effective approach for preventing early Mollicute infection and hyperammonemia syndrome.
Lalithaa Thirunavukarasu Murugan, Anika Sasidharan Nair, Marie M. Budev, Maureen Converse, Nabin K. Shrestha, Christine E. Koval   +5 more
wiley   +1 more source

ARC in Critical Ill OLT Recipients: True Prevalence, Risk Factors, and Impact on Early Aggressive PK/PD Target Non‐Attainment of CI Beta‐Lactam Therapy for Posttransplant Gram‐Negative Infections

Transplant Infectious Disease, EarlyView.
Augmented renal clearance (ARC) represents a quite prevalent condition among critical orthotopic liver transplant recipients (23.2%). ARC is associated with different demographics and clinical features and significantly affects the attainment of aggressive beta‐lactams pharmacokinetic/pharmacodynamic targets despite the administration of standard ...
Milo Gatti, Riccardo De Paola, Matteo Rinaldi, Cristiana Laici, Antonio Siniscalchi, Pierluigi Viale, Federico Pea   +6 more
wiley   +1 more source

Therapeutic drug monitoring and the role of pharmacokinetics/pharmacodynamics in optimizing beta-lactam antibiotic dosing for deep-seated infections: a systematic review. [PDF]

J Antimicrob Chemother
Vale C, Sime FB, Cotta MO, Eriksson L, Roberts JA, Horvath R, Abdul-Aziz MH.   +6 more
europepmc   +1 more source

Perioperative Prophylaxis in Pediatric Solid Organ Transplantation: A Baseline Stewardship Audit Using Routine Electronic Data

Transplant Infectious Disease, EarlyView.
Using routine electronic data from 164 pediatric transplants, we created reproducible stewardship measures of perioperative prophylaxis practice across transplant populations and protocol pathways. Starting prophylaxis was reliable, but continuation beyond intended stop targets—especially in abdominal transplantation—identified the clearest target for ...
Charles B. Foster, Kaitlyn Rivard, Venkatraman A. Arakoni, Blanca E. Gonzalez   +3 more
wiley   +1 more source