Results 191 to 200 of about 89,494 (296)

Beta-lactam dose reductions in critically ill patients with acute kidney injury: a scoping review. [PDF]

Crit Care
Horstink MMB, Rietdijk WJR, Geel DR, Deetman PE, Endeman H, Koch BCP, den Uil CA.   +6 more
europepmc   +1 more source

Recent Advances in Intramolecular C─N Bond Formation for Pyrrolidine Synthesis

ChemistryOpen, Volume 15, Issue 6, June 2026.
This review highlights synthetic advances (2013–2025) in intramolecular C─N bond formation for constructing the pharmaceutically relevant pyrrolidine core. The review is organized into five methodological clusters: 1) intramolecular alkene/alkyne amination; 2) tandem annulations, which involve C─N bond formation as the key step; 3) nucleophilic ...
Rasma Kroņkalne, Māris Turks
wiley   +1 more source

Impact of Extending Beta-Lactam Infusions on IV Access Requirements. [PDF]

Crit Care Explor
Kooda KJ, Nelson J, Ausman SE, Rivera CG, Abu Saleh OM, Rule AD, Stevens RW, Warfield MN, Zhao Y, Barreto EF, Beta Lactam Optimization and Outcomes Management (BLOOM) Study Group.   +10 more
europepmc   +1 more source

Pharmacokinetic Analysis of Intravenous Push Cefepime in Critically Ill Patients With Sepsis

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 6, June 2026.
ABSTRACT Background Intravenous push (IVP) administration of cefepime increases ease of preparation and limits the need for small volume parenterals. The data on IVP pharmacokinetic/pharmacodynamic (PK/PD) parameters are limited, but may be especially relevant in critically ill patients with altered PK/PD for time‐dependent antibiotics like cefepime ...
Susan E. Smith, Rehana Bagodiya, Phuong Luong, Sakshi Shinde, Christopher M. Bland, Christopher Barry, Michael G. Bartlett, Nicholas R. Fox, Trisha N. Branan   +8 more
wiley   +1 more source

Effects of CwlM, a peptidoglycan synthesis regulator, on beta-lactam tolerance and host-pathogen interactions. [PDF]

BMC Microbiol
Silveiro C, Mortinho D, Olivença F, Mandal M, Pires D, Anes E, Catalão MJ.   +6 more
europepmc   +1 more source

Functional dynamics of water in New Delhi metallo‐β‐lactamase catalysis

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Water plays a critical role in the hydrolysis of antibiotics by New Delhi metallo‐β‐lactamases (NDMs). The reaction proceeds through a nucleophilic attack on the β‐lactam ring, followed by cleavage of the C–N bond and formation of an anionic nitrogen intermediate. This intermediate is then protonated by a water molecule diffusing from the bulk
Palanisamy Kandhan, Chuanye Xiong, Timothy Palzkill, Peng Tao   +3 more
wiley   +1 more source

Reply to Lai and Huang, "Which beta-lactam infusion strategy is superior in ICU pneumonia? A Bayesian network meta-analysis of continuous, extended, and intermittent approaches". [PDF]

Antimicrob Agents Chemother
Li Y, Roberts JA, Abdul-Aziz MH, Sime FB.   +3 more
europepmc   +1 more source

Protective effect of snail secretion filtrate in an in vitro model of mastitis

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Bovine mastitis is inflammation of the mammary gland mainly caused by bacterial infections, with relevant economic costs and implications related to antibiotic resistance. In light of the increasing demand for sustainable therapies, this study evaluated the anti‐inflammatory and antioxidant effects of snail secretion filtrate (SSF ...
Gianluca Antonio Franco, Ylenia Marino, Rosalia Crupi, Davide di Paola, Salvatore Cuzzocrea, Enrico Gugliandolo   +5 more
wiley   +1 more source

Isolation, characterisation and potential applications of a novel bacteriophage targeting beta-lactam-resistant Staphylococcus saprophyticus. [PDF]

Sci Rep
Gopika O, Sarat N, Manikandan M, Sumana S, Mohanan PCP, Madhavan A, Varma RS, Mahapatra S, Nair BG, Pal S.   +9 more
europepmc   +1 more source

High Resistance and Biofilm Tolerance to Antimicrobials of Marine Bacteria From Brazilian Deep‐Sea Sediment

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
Antimicrobial resistance and biofilm‐specific tolerance of cultivable Pseudomonas, Bacillus, Brevibacillus and Paenibacillus isolated from deep‐sea sediments of a methane‐seep area off the Southern Brazilian coast. These findings underscore the role of deep‐sea environments as potential reservoirs for antimicrobial‐resistant bacteria (ARB) and ...
Amanda Simão Dias, Sílvia Dias de Oliveira, Renata Medina‐Silva   +2 more
wiley   +1 more source