Results 91 to 100 of about 40,704 (257)

Association between HLA alleles and beta-lactam antibiotics-related severe cutaneous adverse reactions

Frontiers in Pharmacology, 2023
Introduction: Beta-lactam antibiotics are one of the most common causes of antibiotics-related severe cutaneous adverse reactions (SCARs) including Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reactions with eosinophilia and ...
Pansakon Wattanachai, Warayuwadee Amornpinyo, Parinya Konyoung, Danklai Purimart, Usanee Khunarkornsiri, Oranuch Pattanacheewapull, Wichittra Tassaneeyakul, Nontaya Nakkam   +7 more
doaj   +1 more source

Benefits and Harms of Antenatal/Intrapartum Screening for Maternal Group B Streptococcus and Use of Intrapartum Antibiotic Prophylaxis Versus Risk‐Based Protocols or No Intervention: A Rapid Review

Acta Paediatrica, EarlyView.
ABSTRACT Aim To synthesise evidence on the effectiveness, harms and benefits of different approaches to prevent early‐onset Group B Streptococcus (EOGBS) and identify gaps in short and longer‐term outcomes. Methods A two‐phase rapid review. Phase 1 included an overview of systematic reviews (SRs).
Pauline Campbell, Cathryn Broderick, Candida Fenton, Bridget Davis, Wei Xu, Alex Todhunter‐Brown, Narendra Aladangady, Richard F. Chin, Rosie Hill, Ryan Kean, Charlotte‐Eve Short, Julie Cowie, NESSIE—NIHR Evidence Synthesis Scotland InitiativE   +12 more
wiley   +1 more source

Digital five-step questionnaire to enhance standard perioperative prophylaxis in surgical patients with reported allergy to beta-lactam-antibiotics

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Most self-reported beta-lactam antibiotic (BLA) allergies are inaccurate. This study evaluated a digital tool designed to reassess beta-lactam allergies and enable the use of standard perioperative antibiotic prophylaxis (PAP) without the ...
Daniel Röder, Kathrin Eichhorn, Johanna Stoevesandt, Jan Stumpner, Patrick Meybohm, Güzin Surat   +5 more
doaj   +1 more source

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, EarlyView.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

P-953. Stratifying Reaction Histories of Hospitalized Patients with a Beta-Lactam Allergy to Improve Beta-Lactam Utilization in a Large Healthcare System [PDF]

Open Forum Infect Dis
Background A beta-lactam allergy label (BAL) limits healthcare providers' options for antibiotics, forcing them to use non-beta-lactam alternatives.
Aaron Oliver, Emma Ku, Erin Weslander, Rishita Shah, Jaime L Borkowski, Mike Postelnick, Sarah H. Sutton, Michael Dickens, M. Carey, Stephanie Chang, Radhika S. Polisetty, Sheila K Wang   +11 more
europepmc   +2 more sources

Quality and Consistency of Penicillin Allergy Delabelling Guidelines: A Systematic Review

Clinical &Experimental Allergy, EarlyView.
Eighteen penicillin allergy delabelling guidelines from 12 countries were reviewed. There is consensus for staged risk‐based testing, with emerging support for direct oral challenge in low‐risk patients and expanded non‐specialist roles. Overall guideline quality was low, with major gaps in methodological rigour, stakeholder involvement, and ...
Jessie He, Marina Guirguis, Sankare Devanandan, Rani Scott‐Farmer, Sandra Vale, Michaela Lucas, Jennifer J. Koplin, Catherine J. Hornung, Sandra M. Salter   +8 more
wiley   +1 more source

Evaluation and characterization of 125 patients with a history of reaction to beta-lactams

Revista Alergia México, 2016
Background: Reactions to beta-lactams are frequent and it is difficult to establish the relationship between the drug and symptoms. Objective: To describe the clinical characteristics and explore the immunological mechanisms of patients with suspected ...
Kaddy Juliana Beltrán-Sierra, Jorge Sánchez, Ricardo Cardona   +2 more
doaj   +1 more source

Constitutional symptoms and response to Penicillin G in erysipelas and cellulitis – a monocentric, retrospective, explorative study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background: Erysipelas, caused by streptococci, should be treated with penicillin, while uncomplicated cellulitis (phlegmon), often caused by Staphylococcus aureus, requires penicillinase‐resistant beta‐lactam antibiotics, which have a higher risk of adverse effects. Distinguishing between these infections is important.
Helena Schieffers, Cord Sunderkötter
wiley   +1 more source

Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury [PDF]

, 2015
Drug-induced liver injury (DILI) is a major concern for public health, as well as for drug development in the pharmaceutical industry, since it can cause liver failure and lead to drug withdrawal from the market and black box warnings.
Kim, Seung-Hyun, Naisbitt, Dean J
core   +1 more source

Documented penicillin allergy and beta-lactam antibiotic use in Massachusetts long-term care facilities: opportunities for penicillin allergy delabeling

Antimicrobial Stewardship & Healthcare Epidemiology
In a cross-sectional study of 20 Massachusetts long-term care (LTC) facilities, 19% (n = 449) of residents received antibiotics, with approximately one-third having a documented penicillin allergy.
Kap Sum Foong, Shira Doron, Leslie Fowle, Melissa Cumming, Jessica Leaf, Barbara Bolstorff, Christina Brandeburg, Ye Chen, Alysse Wurcel   +8 more
doaj   +1 more source