Results 111 to 120 of about 61,855 (219)

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, Volume 183, Issue 22, Page 6607-6626, November 2026.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Fosfomycin Resistance Dynamics in Major Uropathogens: A 2013-2025 Integrated Disease Surveillance of Multidrug-Resistant, Extended-Spectrum Beta-Lactamase-Producing, Non-Extended-Spectrum Beta-Lactamase, and Enterococcal Urinary Isolates. [PDF]

Pathogens
Saeed U, Uppal R, Zaman G, Uppal MR, Szepesváry ZJ, Khan AA, Qamar MU, Ali Z, Piracha ZZ.   +8 more
europepmc   +1 more source

Beta-Lactamase [PDF]

, 2020
openaire   +1 more source

A retrospective analysis of bacterial pathogens in wounds in an equine hospital (2017–2022)

Equine Veterinary Education, Volume 38, Issue 11, Page e910-e918, November 2026.
Summary Background Bacterial infections are a major cause of morbidity in horses, particularly in soft tissue wounds (STW) and surgical site infections (SSI). Rising antimicrobial resistance poses challenges for timely treatment. Knowledge of common pathogens and their resistance patterns is therefore essential.
J. Nebes, M. Schneeberger, S. Schmitt, J. N. van Spijk   +3 more
wiley   +1 more source

Characterization of beta-lactamases

Antimicrobial Agents and Chemotherapy, 1989
openaire   +3 more sources

Beta-lactamases [PDF]

Journal of Medical Microbiology, 1980
openaire   +1 more source

Antimicrobial Resistance in Periodontal Disease: Rethinking Adjunctive Therapy in the Metagenomics Era, the Pressing Need for Precision Treatment and Periodontal Resistome Mapping

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Systemic antibiotics are effective when used as adjunctive therapy in the treatment of periodontitis; however, their use must be balanced against antimicrobial resistance, which is a major threat to global public health. This review provides an expert synthesis of the literature and a field‐level overview of antimicrobial resistance in ...
Meera Alghafri, Lindsey Edwards, David Moyes, Luigi Nibali   +3 more
wiley   +1 more source

Optimized Flomoxef Dosing Strategy for Extended-Spectrum Beta-Lactamase-Producing Bacteria, Based on Pooled Pharmacokinetic and Pharmacodynamic Analysis. [PDF]

Pharmaceutics
Onita T, Sano Y, Kuruma N, Ikawa K, Ishihara N, Tamaki H, Yagi K, Yano T.   +7 more
europepmc   +1 more source

A Lambda Red Recombinase‐Assisted CRISPR/Cas9 System for Efficient and Precise Genome Editing in Agrobacterium tumefaciens

Plant Biotechnology Journal, Volume 24, Issue 11, Page 6010-6027, November 2026.
ABSTRACT Agrobacterium tumefaciens is a powerful delivery tool for plant genetic transformation and a pivotal platform for agricultural biotechnology. However, laboratory strains of Agrobacterium have remained genetically unoptimized for decades, with genome engineering hindered by inefficient, endogenous homologous recombination systems.
Minmin Zheng, Rui Liu, Wei‐Chang Huang, Zuren Li, Kai Hua   +4 more
wiley   +1 more source

Phenotypic and Genotypic Detection of Extended-Spectrum Beta-Lactamase (ESBL) and Metallo-Beta-Lactamase (MBL) Genes in Multidrug-Resistant Acinetobacter baumannii Isolates Derived From Diabetic Foot Ulcer Patients. [PDF]

Cureus
Gupta HK, Karicheri R, Mehta A.
europepmc   +1 more source