Results 1 to 10 of about 811,638 (168)

Metallo-Beta-Lactamases: NDM [PDF]

Journal of Education, Health and Sport, 2019
New Delhi, an enzyme belonging to the Metallo-beta-lactamases and Carbapenemases group, is most commonly found in Klebsiella pneumoniae and Escherichia coli. It determines these bacteria resistance to the majority of known antibiotics.
Kamil Leis, Ewelina Mazur, Paweł Szyperski, Patryk Kaczor, Michalina Kolan, Bartłomiej Wiśniewski, Magdalena Jabłońska, Aleksandra Kulczyńska, Aleksandra Baska, Jakub Kazik, Daria Bojczuk, Klaudyna Grzelakowska, Krystian Kałużny, Przemysław Gałązka   +13 more
doaj   +9 more sources

Investigation of Metallo Beta Lactamases and Oxacilinases in Carbapenem Resistant Acinetobacter baumannii Strains Isolated from Inpatients

Balkan Medical Journal, 2015
Background: Resistance to beta-lactam antibiotics is widespread among Acinetobacter strains. Plasmid-mediated metallo beta lactamases (MBL) are responsible for carbapenem resistance, as are oxacillinases (OXA).
M. Duygu Aksoy, Şaban Çavuşlu, H. Murat Tuğrul   +2 more
doaj   +3 more sources

Antimicrobial resistance of gram-negative pathogens isolated from hospitalized patients in Rostov region [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2020
Objective. To evaluate resistance rates to carbapenems and III–IV generation cephalosporins among gramnegative bacteria, including production of carbapenemases and extended-spectrum beta-lactamases (ESBL). Materials and Methods.
Kutsevalova O.Yu., Kozel Yu.Yu., Rozenko D.A., Martynov D.V., Korshunkova O.V.   +4 more
doaj   +1 more source

Phenotypic Characterization of Extended-Spectrum Beta-Lactamases and Metallo-Beta-Lactamase of Multi Drug Resistant Acinetobacter baumannii Causing Nosocomial Infections in Erbil City

Al-Mustansiriyah Journal of Science, 2020
Background: Resistance to broad‑spectrum beta‑lactams, mediated by extended‑spectrum beta‑lactamases, and metallo‑beta‑lactamase enzymes, is an increasing problem worldwide.
Sakar Bakr Smail, Kamal I. AL-OTRACHI
doaj   +1 more source

Successful Management of Urosepsis with Ceftriaxone+Sulbactam+EDTA: A Case Report of Penem Sparing Approach [PDF]

Journal of Clinical and Diagnostic Research, 2017
Over the past decade, the Anti-Microbial Resistance (AMR) among members of Enterobacteriaceae family is on rise mainly due to rapid spread of strains producing Extended-Spectrum Beta-Lactamases (ESBLs) and Metallo Beta-Lactamases (MBLs).
Amit Bery, Candy Sodhi, Rishu Bhanot
doaj   +1 more source

A promiscuous ancestral enzyme´s structure unveils protein variable regions of the highly diverse metallo-β-lactamase family

Communications Biology, 2021
The structure of Igni18, ancient enzyme from the Crenarchaean species Ignicoccus hospitalis, is solved and characterized by Pérez-García, Chow and colleagues.
Pablo Perez-Garcia, Stefanie Kobus, Christoph G. W. Gertzen, Astrid Hoeppner, Nicholas Holzscheck, Christoph Heinrich Strunk, Harald Huber, Karl-Erich Jaeger, Holger Gohlke, Filip Kovacic, Sander H. J. Smits, Wolfgang R. Streit, Jennifer Chow   +12 more
doaj   +1 more source

Detection of Beta-Lactamases (ESBL and MBL) Producing Gram-Negative Pathogens in National Public Health Laboratory of Nepal

International Journal of Microbiology, 2022
Background. Bacterial resistance to antibiotics has increased in recent years. Resistance to β-lactams in Gram-negative bacteria has been reported to be associated with extended spectrum beta-lactamases and metallo-beta-lactamases.
Anjana Shrestha, Jyoti Acharya, Jyoti Amatya, Rabin Paudyal, Nisha Rijal   +4 more
doaj   +1 more source

Analysis of Class 1 Integrons and Antibiotic Resistance Genes in Pseudomonas aeruginosa Strains from Benin City, Nigeria

Journal of Applied Sciences and Environmental Management, 2020
The presence of integrons and antibiotic resistance genes in the genome of Pseudomonas aeruginosa pose a serious problem in the treatment and control of infections caused by this pathogen in hospitals.
B.O. Isichei-Ukah, O.I. Enabulele
doaj   +1 more source

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

Nature Communications, 2016
Bacterial beta-lactamases are responsible for resistance to beta-lactams, the most important family of antibiotics. Here, the authors reveal cyclic boronate inhibitors that are active against both serine- and metallo-beta-lactamases and represent a ...
Jürgen Brem, Ricky Cain, Samuel Cahill, Michael A. McDonough, Ian J. Clifton, Juan-Carlos Jiménez-Castellanos, Matthew B. Avison, James Spencer, Colin W. G. Fishwick, Christopher J. Schofield   +9 more
doaj   +1 more source

Ventilator-associated pneumonia in a tertiary care hospital in India: role of multi-drug resistant pathogens

Journal of Infection in Developing Countries, 2010
Background: Ventilator-Associated Pneumonia (VAP) is the most frequent intensive-care-unit (ICU)-acquired infection. The aetiology of VAP varies with different patient populations and types of ICUs.
Noyal Mariya Joseph, Sujatha Sistla, Tarun Kumar Dutta, Ashok Shankar Badhe, Desdemona Rasitha, Subhash Chandra Parija   +5 more
doaj   +1 more source