Results 21 to 30 of about 811,638 (168)

Identification of 76 novel B1 metallo-beta-lactamases through large-scale screening of genomic and metagenomic data [PDF]

, 2017
Background: Metallo-beta-lactamases are bacterial enzymes that provide resistance to carbapenems, the most potent class of antibiotics. These enzymes are commonly encoded on mobile genetic elements, which, together with their broad substrate spectrum and
Österlund, Tobias, Fanny Berglund, Carl-Fredrik Flach, Berglund, Fanny, D G Joakim Larsson, Larsson, D. G. Joakim, Kotsakis, Stathis,, Nachiket P. Marathe, Berglund, Fanny,, Kotsakis, S., Kristiansson, Erik,, Bengtsson Palme, Johan,, Kristiansson, Erik, Marathe, Nachiket,, Marathe, Nachiket, Flach, Carl-Fredrik,, Österlund, Tobias,, Bengtsson-Palme, Johan,, Erik Kristiansson, Johan Bengtsson-Palme, 6sterlund, Tobias, Larsson, D. G. Joakim,, Tobias Österlund, Bengtsson-Palme, Johan, Stathis Kotsakis, Flach, Carl-Fredrik   +25 more
core   +1 more source

Prevalence of extended-spectrum beta-lactamases, AmpC beta-lactamase, and metallo-beta-lactamase producing Pseudomonas aeruginosa and Acinetobacter baumannii in an intensive care unit in a tertiary care hospital

Journal of the Scientific Society, 2013
Background: Resistance to broad-spectrum beta-lactams, mediated by extended-spectrum beta-lactamases (ESBL), AmpC beta-lactamase, and metallo-beta-lactamase (MBL) enzymes, is an increasing problem worldwide. Aim of the study: This study was undertaken to
Varun Goel, Sumati A Hogade, S G Karadesai   +2 more
doaj   +1 more source

Specific Protein-Membrane Interactions Promote Packaging of Metallo-beta-Lactamases into Outer Membrane Vesicles

, 2021
Outer membrane vesicles (OMVs) act as carriers of bacterial products such as plasmids and resistance determinants, including metallo-beta-lactamases. The lipidated, membrane-anchored metallo-beta-lactamase NDM-1 can be detected in Gram-negative OMVs. The
Bahr, Guillermo, Vila, Alejandro J., Dal Peraro, Matteo, Lopez, Carolina, Prunotto, Alessio, Bonomo, Robert A., Gonzalez, Lisandro J., Dal Peraro, M., Vila, A.J., Bonomo, R.A., López, C., González, L.J., Prunotto, A., Bahr, G., Matteo Dal Peraro, Robert A. Bonomo, Guillermo Bahr, Carolina López, Alejandro J. Vila, Lisandro J. González, Alessio Prunotto   +20 more
core   +1 more source

Detection of Metallo Beta-Lactamase (MBL) Producing

Maedica - A Journal of Clinical Medicine, 2022
Introduction:Pseudomonas aeruginosa is a leading cause of nosocomial infections and is especially prevalent among patients with burn wounds, cystic fibrosis, acute leukemia, organ transplants and intravenous-drug addiction. Acquired metallo-â-lactamases (MBLs) are carbapenemases which require zinc in the active site and are predominantly produced by P.
A, Radhika, Jyothi Tadi, Lakshmi, Kaliappan, Ariyanachi, Varatharajan, Sakthivadivel   +3 more
openaire   +2 more sources

Antibacterial potential of neem (Azadirachta indica) against uropathogens producing beta-lactamase enzymes: A clue to future antibacterial agent?

Biomedical and Biotechnology Research Journal, 2020
Background: Emergence of drug resistance in Gram-negative bacilli due to production of extended-spectrum beta-lactamases (ESBL), metallo-beta-lactamases (MBL), and AmpC beta-lactamase is very common nowadays; therefore, we are left with less choice for ...
Sameer Singh Faujdar, Dakshina Bisht, Amisha Sharma   +2 more
doaj   +1 more source

A multiscale approach to predict the binding mode of metallo beta‐lactamase inhibitors [PDF]

Proteins: Structure, Function, and Bioinformatics, 2021
Abstract Antibiotic resistance is a major threat to global public health. β‐lactamases, which catalyze breakdown of β‐lactam antibiotics, are a principal cause. Metallo β‐lactamases (MBLs) represent a particular challenge because they hydrolyze almost all β‐lactams and to date no MBL inhibitor has been approved for clinical use ...
Silvia Gervasoni, James Spencer, Philip Hinchliffe, Alessandro Pedretti, Franco Vairoletti, Graciela Mahler, Adrian J. Mulholland   +6 more
openaire   +3 more sources

A minimalistic approach to identify substrate binding features in B1 Metallo-beta-lactamases [PDF]

, 2007
International audienceThe 2-oxoazetidinylacetate sodium salt was synthesized as a model of a minimal P-lactam drug. This compound and the monobactam aztreonam were assayed as substrates of the Metallo-p-lactamase Bell.
Vila, A.J., Damblon, Christian, Mata, E.G., Tomatis, P.E., Poeylaut-Palena, A.A., Karsisiotis, A.I.   +5 more
core   +4 more sources

Beta lactamases mediated resistance amongst gram negative bacilli in burn infection [PDF]

International Journal of Biological and Medical Research, 2011
Introduction: Burn is one of the most common and devastating forms of trauma. Patients with serious thermal injury require immediate specialized care in order to minimize morbidity and mortality.
Nitin Bandekar, Vinodkumar CS, Basavarajappa KG, Prabhakar PJ, Nagaraj P   +1 more
doaj  

ENTEROBACTERIACAE, PRODUCING ESBLS AND METALLO-β-LACTAMASE NDM-1, ISOLATED IN HOSPITALS OF BALTIC REGION COUNTRIES

Инфекция и иммунитет, 2014
. We studied the prevalence of K. pneumoniae and E. coli resistance to extended spectrum cephalosporins and carbapenems, isolated from patients of eight hospitals in St-Petersburg from January to May, 2012.
S. A. Egorova, L. A. Kaftyreva, L. V. Lipskaya, I. B. Konovalenko, M. F. Pyasetskaya, T. S. Kurchikova, N. B. Vedernikova, O. T. Morozova, M. V. Smirnova, L. N. Popenko, M. I. Lubushkina, J. A. Savochkina, M. A. Makarova, L. V. Suzhaeva, J. V. Ostankova, M. N. Ivanova, A. M. Pavelkovich, P. Naaber, E. Sepp, S. Kõljalg, J. Miciuleviciene, A. Balode   +21 more
doaj   +1 more source

Designing novel inhibitors for Metallo beta-lactamases.

, 2016
The extensive use of beta-lactam antibiotics has created major resistance problems leading to increased morbidity, mortality and health-care costs. Resistance is most often mediated by beta-lactamases (BLs), which have emerged in both Gram-positive and Gram-negative bacteria [1,2].
TONDI, Donatella
openaire   +2 more sources