Results 91 to 100 of about 1,053,591 (371)

Identification of extended spectrum beta lactamases, AmpC and carbapenemase production among isolates of Escherichia coli in North Indian tertiary care centre

Avicenna Journal of Medicine, 2018
Introduction: Identification of Extended spectrum beta lactamases (ESBL), AmpC production and carbapenemase production among isolates of Escherichia coli, helps clinician to rationalize the choice of antibiotics.
Uma Chaudhary, Shipra Agarwal, Kausalya Raghuraman   +2 more
doaj   +1 more source

Escape mutations circumvent a tradeoff between resistance to a beta-lactam and resistance to a beta-lactamase inhibitor

Nature Communications, 2020
Beta-lactam antibiotics and beta-lactamase inhibitors compete for the same binding site on beta-lactamases; thus, mutations that increase beta-lactamase activity likely increase also susceptibility to the inhibitor. Here, Russ et al.
Dor Russ, Fabian Glaser, Einat Shaer Tamar, Idan Yelin, Michael Baym, Eric D. Kelsic, Claudia Zampaloni, Andreas Haldimann, Roy Kishony   +8 more
doaj   +1 more source

Resistome flow in global landfill systems

iMetaOmics, EarlyView.
Global landfill systems represent key hubs of resistome, serving as dynamic reservoirs and amplifiers through plasmid‐driven gene mobility. Waste flows and environmental pathways sustain the transboundary resistome networks, accelerating resistance dissemination across ecosystems.
Wenqing Hong, Rui Zhang, Xiaoxing Lin, Yangqing Wang, Shu Yang, Farees ud din Mufti, Yuping Yao, Guowei Zhou, Chuanwu Xi, Weixi Shu, Gordon Price, Youcai Zhao, Liyan Song   +12 more
wiley   +1 more source

Novel Computational Protocols for Functionally Classifying and Characterising Serine Beta-Lactamases.

PLoS Computational Biology, 2016
Beta-lactamases represent the main bacterial mechanism of resistance to beta-lactam antibiotics and are a significant challenge to modern medicine. We have developed an automated classification and analysis protocol that exploits structure- and sequence ...
David Lee, Sayoni Das, Natalie L Dawson, Dragana Dobrijevic, John Ward, Christine Orengo   +5 more
doaj   +1 more source

Evaluation of phenotypic tests for the detection of AmpC beta-lactamase in clinical isolates of Escherichia coli

Indian Journal of Pathology and Microbiology, 2013
Background: AmpC beta lactamases are cephalosporinases that confer resistance to a wide range of beta lactam drugs thereby causing serious therapeautic problem.
Deepika Handa, Anita Pandey, Ashish Kumar Asthana, Ashutosh Rawat, Seemant Handa, Bhaskar Thakuria   +5 more
doaj   +1 more source

Evaluation of Ceftriaxone as a Monotherapy and Amoxicillin With Clavulanic Acid as Combination Therapy in Surgical Prophylaxis

iNew Medicine, EarlyView.
ABSTRACT Surgical antibiotic prophylaxis (SAP) is crucial in preventing postoperative surgical site infections (SSIs), especially in clean and clean‐contaminated surgeries. It was a prospective comparative observational study that compared the effectiveness and safety of single‐dose ceftriaxone monotherapy with amoxicillin–clavulanic acid as a ...
Anayat Ullah, Arsh Ali, Md Nematullah, Suriya Kumar Singh, Anant Singh Paliwal, Najish Parveen   +5 more
wiley   +1 more source

Phenotypic characterization of beta-lactamases producing Gram-negative bacteria in a tertiary hospital, Nepal

Nepal Journal of Biotechnology, 2019
Infections caused by beta-lactamases producing Gram-negative bacteria are increasing, thus posing a challenge to the management of such infections.
Elina Maharjan, Pooja Shakya, Balkrishna Bhattachan, Bharat Prasad Baral, Dhiraj Shrestha   +4 more
doaj   +1 more source

Antimicrobial Resistance Patterns in Clinical Isolates of Enterobacteriaceae from a Tertiary Care Hospital, Kathmandu, Nepal

Nepalese Medical Journal, 2018
Introduction: Multidrug resistance among Enterobacteriaceae is in increasing trend these days. The objective of this study was to determine the antibiogram of clinical isolates of Enterobacteriaceae with special reference to multidrug resistance and ...
Ram Prasad Adhikari, Subha Shrestha, Junu Richhinbung Rai, Ritu Amatya   +3 more
doaj   +1 more source

Validation of Hexaplex Recombinase Polymerase Amplification Assay for the Detection of Carbapenemase Genes in Klebsiella pneumoniae Isolates From Pediatric Inpatients

Journal of Clinical Laboratory Analysis, EarlyView.
A novel hexaplex recombinase polymerase amplification (RPA) method was developed to rapidly and accurately detect five key carbapenemase genes and a Klebsiella pneumoniae‐specific target in a single reaction. This makes it an effective tool for CRKP detection in resource‐constrained environments.
Suthawan Mutitanon, Nuntaree Chaichanawongsaroj   +1 more
wiley   +1 more source

High Carriage of Extended-Spectrum, Beta Lactamase-Producing, and Colistin-Resistant Enterobacteriaceae in Tibetan Outpatients with Diarrhea [PDF]

, 2022
Zhe Li, Jiaqi Li, Jiaqi Liu, Yao Peng, Zhenpeng Li, Mengyu Wang, Ge Zhang, Geruo Qu, Jingyun Zhang, Xiuping Fu, Xia Chen, Ciren Dunzhu, Shan Lü, Xin Lü, Jialiang Xu, Biao Kan   +15 more
openalex   +1 more source