Results 101 to 110 of about 597,070 (286)
Metallo-beta-lactamases: a last frontier for beta-lactams? [PDF]
, 2011 Metallo-beta-lactamases are resistance determinants of increasing clinical relevance in Gram-negative bacteria. Because of their broad range, potent carbapenemase activity and resistance to inhibitors, these enzymes can confer resistance to almost all ...
Giamarellou, Helen +2 more
core
COMPARACIÓN DE LA PRUEBA TRIDIMENSIONAL CON PCR MÚLTIPLE, PARA DETECCIÓN DE CARBAPENEMASAS
Infectio, 2018 Objective: To compare the phenotypic test for detection of carbapenemases (Three-dimensional Test - THT), with molecular biology test (Multiplex PCR), for the detection of resistance genes.
María Isabel Múnera-Jaramillo
doaj +1 more source
Acta Paediatrica, EarlyView.ABSTRACT Aim We retrospectively evaluated trends in antimicrobial resistance (AMR) in paediatric bloodstream infections and assessed changes in antimicrobial prescription patterns over a 20‐year period. Methods We analysed positive blood cultures from children admitted with suspected serious infection between 1998 and 2018.
Joachim Luthander +5 more
wiley +1 more source
Phenotypic Detection of Beta-Lactamases Production in Enterobacteriaceae [PDF]
, 2014 Introduction Beta-lactam antibiotics are the most commonly used antibacterial drugs. However, many bacteria have developed resistance to these antibiotics, and the most common form of resistance. is the production of beta-lactamase enzymes.
Ćirković, Ivana +5 more
core +1 more source
Carriage of antimicrobial‐resistant E. coli in urban stray cats (Felis catus)
Australian Veterinary Journal, EarlyView.Antimicrobial resistance (AMR) in Escherichia coli is a growing concern in both human and veterinary medicine, driven by the inappropriate use of antimicrobials. Companion animals may act as community reservoirs and sentinels for antimicrobial‐resistant bacteria due to their close contact with humans and other animals.
JS Kuan, S Mukerji, D Hampson, S Abraham
wiley +1 more source
Cloning and characterization of the endogenous cephalosporinase gene, cepA, from Bacteroides fragilis reveals a new subgroup of Ambler class A beta-lactamases. [PDF]
, 2023 Bacteroides frgiglis CS30 is a clinical isolate resistant to high concentrations of benzylpenicillin and cephaloridine but not to cephamycin or penem antibiotics.
Smith, C. Jeffrey +3 more
core
Allergic Reactions and Cross-Reactivity Potential with Beta-Lactamase Inhibitors
Pharmacy, 2019 Although beta-lactam allergies are an emerging focus of stewardship programs and interventions, less is publicly released regarding allergies to beta-lactamase inhibitors. This review presents and evaluates the data regarding allergic reactions with beta-
Kayla R. Stover +2 more
doaj +1 more source
Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries
British Journal of Pharmacology, EarlyView.Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley +1 more source
Metallo-beta-lactamases and their biomimetic complexes [PDF]
, 2014 In order to treat bacterial infections successfully in the future, the mechanism of action of metallo-beta-lactamases (M beta Ls) needs to be fully understood so that clinically useful inhibitors and new therapeutic approaches can be developed.
Schenk, Gerhard +2 more
core +1 more source
European Journal of Haematology, EarlyView.ABSTRACT Background Bloodstream infections remain a major cause of mortality among cancer patients. Pathogen surveillance and risk stratification tools are key to improved management. This study describes trends in causative pathogens and explores risk factors for positive blood cultures (PBCs) and post‐infection mortality in cancer patients.
Mathias Holmsgaard Eskesen +7 more
wiley +1 more source