Results 121 to 130 of about 1,753,858 (323)

Pharmacokinetics of Long‐Acting Ampicillin and Its Impact on the Gut Microbiome and Resistome in Rhesus Macaques (Macaca mulatta)

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Injectable antimicrobials with documented prolonged dosing intervals (> 48 h) for use in rhesus macaques are sparse. The objective of our study was to assess the pharmacokinetics, urine excretion, and effects on gut microbiome and resistome of intramuscular administered long‐acting formulation of ampicillin (Albipen LA) in macaques.
Annemiek Maaskant, Ingeborg M. van Geijlswijk, Mathias Devreese, Marc Cherlet, Leo F. van Geest, Jaap A. Wagenaar, Jan A. M. Langermans, Aldert L. Zomer, Jaco Bakker, Ronette Gehring   +9 more
wiley   +1 more source

Proposed Meropenem Breakpoints for Interpretation of Antimicrobial Susceptibility Testing of Bacteria Isolated From Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Meropenem is a carbapenem antibiotic used infrequently in veterinary medicine. However, antimicrobial susceptibility testing standards are needed to monitor for resistance caused by carbapenem resistant Enterobacterales (CRE). The Clinical and Laboratory Standards Institute (CLSI) does not have veterinary‐specific carbapenem breakpoints for ...
Mark G. Papich, Marilyn N. Martinez
wiley   +1 more source

Frecuencia de aislamientos ambientales de Staphylococcus aureus y su actividad beta-lactamasa en un hospital de Cajamarca, Perú Frequency of Staphylococcus aureus environmental isolations and beta-lactamase activity at a hospital of Cajamarca, Perú

Infectio, 2009
Objetivo. Determinar la frecuencia de aislamientos de Staphylococcus aureus y su capacidad para producir beta-lactamasas clásicas, en reservorios ambientales de las salas de operaciones del Servicio de Cirugía y de las salas de partos del Servicio de ...
Marco Rivera-Jacinto, Claudia Rodríguez-Ulloa, Gladys Huayán-Dávila   +2 more
doaj  

In silico Molecular Docking of Cyclic Peptides against TEM-1 Beta-Lactamases for Effective Antimicrobial Drug Development

Targeting the class A Beta lactamases Omega loop is an ideal way to combat drug resistance because of its significant role in the catalytic activity and deacylation process inhibition.
Santhoshkumar Jayakodi, A. Sowmiya, K. Sangeetha, K.A. Selvam   +3 more
core   +1 more source

ß-Lactam-ß-lactamase Inhibitor Combination against ESBL-Producing Enterobacteriaceae

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2016
In the last decades, Extended-Spectrum-β-Lactamases (ESBLs) in gram negative bacilli have appeared as a significant mechanism of resistance to antibiotics. Although resistance to carbapenems is increasing among bacteria, they are still the treatment
A Hashemi
doaj  

Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases

, 2001
Penicillins and cephalosporins are among the most widely used and successful antibiotics. The emergence of resistance to these beta -lactams, most often through bacterial expression of beta -lactamases, threatens public health.
Blasczcak LC, Wu CYE, CASELLI, Emilia, Powers RA, Shoichet BK, PRATI, Fabio   +5 more
core   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

Carbapenemases from the Laboratory to the Clinic in Gram-Negative Enteric Bacteria [PDF]

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2012
In gram-negative bacteria, antimicrobial resistance related to beta-lactamases is a serious problem in the management of healthcare- related infections.
Sinem BUDAK, Zerrin AKTAŞ, Hakan ERDEM
doaj  

A functional classification scheme for beta-lactamases and its correlation with molecular structure

Antimicrobial Agents and Chemotherapy, 1995
K. Bush, G. Jacoby, Andantone A. Medeiros   +2 more
semanticscholar   +1 more source

ARC in Critical Ill OLT Recipients: True Prevalence, Risk Factors, and Impact on Early Aggressive PK/PD Target Non‐Attainment of CI Beta‐Lactam Therapy for Posttransplant Gram‐Negative Infections

Transplant Infectious Disease, EarlyView.
Augmented renal clearance (ARC) represents a quite prevalent condition among critical orthotopic liver transplant recipients (23.2%). ARC is associated with different demographics and clinical features and significantly affects the attainment of aggressive beta‐lactams pharmacokinetic/pharmacodynamic targets despite the administration of standard ...
Milo Gatti, Riccardo De Paola, Matteo Rinaldi, Cristiana Laici, Antonio Siniscalchi, Pierluigi Viale, Federico Pea   +6 more
wiley   +1 more source