Results 111 to 120 of about 57,530 (301)

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Draft Genome Sequence of Mycobacterium obuense Strain UC1, Isolated from Patient Sputum. [PDF]

, 2015
We report the draft genome sequence of Mycobacterium obuense strain UC1 from a patient sputum sample. This is the first draft genome sequence of Mycobacterium obuense, a rapidly growing scotochromogenic ...
Chiu, Charles Y, Cunningham, Gail, Greninger, Alexander L, Hsu, Elaine D, Miller, Steve, Yu, Joanna M   +5 more
core   +2 more sources

Inhibition of metallo-beta-lactamases by a series of mercaptoacetic acid thiol ester derivatives [PDF]

, 1997
David J. Payne, John H. Bateson, B C Gasson, David G. Proctor, Teresa Khushi, T H Farmer, D A Tolson, David Bell, P W Skett, A. C. MARSHALL, Robert G. B. Reid, Léon Ghosez, Yann Combret, Jacqueline Marchand‐Brynaert   +13 more
openalex   +1 more source

S1 Guideline on Infected Interdigital Intertrigo (also called Gram‐Negative Toe Web Infection)

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Infected interdigital intertrigo is an exudative, macerating, mixed infection of the toe webs in which gram‐negative bacteria (Pseudomonas aeruginosa and Enterobacterales) seem prevalent, but in which gram‐positive pathogens (Staphylococcus [S.] aureus, streptococci, enterococci) and fungi (dermatophytes, yeasts) also occur.
Christoph Zeyen, Dietrich Abeck, Karsten Becker, Joachim Dissemond, Birgit Kahle, Hans Peter Lorenzen, Bettina Löffler, Andreas Maier‐Hasselmann, Till Mittank‐Weidner, Alexander Nast, Cord Sunderkötter   +10 more
wiley   +1 more source

Breakthrough Advances in Beta-Lactamase Inhibitors: New Synthesized Compounds and Mechanisms of Action Against Drug-Resistant Bacteria

Pharmaceuticals
Beta-lactam drugs hold a central place in the antibacterial arsenal, and the production of beta-lactamases by drug-resistant bacteria has severely compromised the effectiveness of nearly all available beta-lactams.
Ya-Si Huang, Hong Zhou
doaj   +1 more source

Carriage Rates and Characteristics of Enterobacteriaceae Producing Extended-Spectrum Beta-Lactamases in Healthy Individuals: comparison of Applicants for Long-Term Care and Individuals Screened for Employment Purposes [PDF]

, 2018
K
Ebrahimi, Fatemeh, Juhász, Ágnes, Kardos, Gábor, Mészáros, Júlia, Mózes, Julianna   +4 more
core   +1 more source

Epidemiologie de l'enterobacterie productrice de beta-lactamase a spectre etendu (blse) et de sa sensibilite aux nouveaux beta-lactamines chez les enfants hospitalises au CHU de cocody

, 2021
N'DRI, Aya Annick Charlène
openalex   +1 more source

Unusual presentation of osteomyelitis of the tuber calcanei in a 16‐month‐old gelding

Equine Veterinary Education, EarlyView.
Summary A 16‐month‐old Morgan gelding was referred for evaluation of a right hindlimb lameness (grade 4/5, AAEP) accompanied by swelling of the right calcaneal region. Clinical signs had been present for approximately 4 weeks prior to referral.
A. M. Arreola, C. Serna, K. G. Mitchell, A. Merchán   +3 more
wiley   +1 more source

European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) 2025 guidelines for surgical antimicrobial prophylaxis in dogs and cats

Journal of Small Animal Practice, EarlyView.
Surgical antimicrobial prophylaxis involves the administration of antimicrobials to reduce the risk of a surgical site infection and represents a significant proportion of all antimicrobial use in cats and dogs. This evidence‐based, European Network for Optimization of Veterinary Antimicrobial Therapy guideline provides recommendations for both peri ...
F. Allerton, T. M. Sørensen, K. Scahill, J. E. Ruperez, F. Swinbourne, D. R. Verwilghen, M. C. Nolff, F. Foroutan, S. J. Baines, A. Vilen, L. Pelligand, E. M. Broens, P. L. Toutain, M. L. Brennan, T. Mooney, S. Clarke, J. E. Miles, J. L. Granick, Y. Winsborg, L. R. Jessen, J. S. Weese, on behalf of the European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) guidelines and the ESCMID Study Group for Veterinary Microbiology (ESGVM)   +21 more
wiley   +1 more source

Beta-Lactamase-Mediated Antibiotic Resistance in Urinary Tract Infections: Mechanisms and Therapeutic Strategies [PDF]

Urogenital Tract Infection
Urinary tract infections (UTIs) are among the most prevalent bacterial infections globally, and are primarily caused by Escherichia and Klebsiella. The overprescription and inappropriate use of antibiotics have accelerated the emergence of multidrug ...
Fanglin Shao, Dengxiong Li, Jie Wang, Zhouting Tuo, Zhipeng Wang, Wuran Wei, Ruicheng Wu, Dechao Feng   +7 more
doaj   +1 more source