Results 91 to 100 of about 781,021 (270)
Nepal Journal of Biotechnology, 2019 Infections caused by beta-lactamases producing Gram-negative bacteria are increasing, thus posing a challenge to the management of such infections.
Elina Maharjan +4 more
doaj +1 more source
Acta Paediatrica, EarlyView.ABSTRACT Aim We retrospectively evaluated trends in antimicrobial resistance (AMR) in paediatric bloodstream infections and assessed changes in antimicrobial prescription patterns over a 20‐year period. Methods We analysed positive blood cultures from children admitted with suspected serious infection between 1998 and 2018.
Joachim Luthander +5 more
wiley +1 more source
Identification of group specific motifs in Beta-lactamase family of proteins
Journal of Biomedical Science, 2009 Background Beta-lactamases are one of the most serious threats to public health. In order to combat this threat we need to study the molecular and functional diversity of these enzymes and identify signatures specific to these enzymes.
Saxena Akansha +2 more
doaj +1 more source
Catalytic Properties of Class a Beta-Lactamases: Efficiency and Diversity [PDF]
, 1998 peer reviewedbeta-Lactamases are the main cause of bacterial resistance to penicillins, cephalosporins and related beta-lactam compounds. These enzymes inactivate the antibiotics by hydrolysing the amide bond of the beta-lactam ring.
Lamotte-Brasseur, Josette +2 more
core +1 more source
Carriage of antimicrobial‐resistant E. coli in urban stray cats (Felis catus)
Australian Veterinary Journal, EarlyView.Antimicrobial resistance (AMR) in Escherichia coli is a growing concern in both human and veterinary medicine, driven by the inappropriate use of antimicrobials. Companion animals may act as community reservoirs and sentinels for antimicrobial‐resistant bacteria due to their close contact with humans and other animals.
JS Kuan, S Mukerji, D Hampson, S Abraham
wiley +1 more source
Detection of zoonotic bacteria in wild Australian freshwater turtles
Australian Veterinary Journal, EarlyView.Freshwater turtles are long‐lived, abundant components of Australian aquatic ecosystems, yet little is known about the diversity and prevalence of zoonotic bacteria they may carry. In this study, we conducted one of the most comprehensive surveys to date of zoonotic microorganisms associated with wild Australian freshwater turtles.
TF Scheelings +3 more
wiley +1 more source
Acute thrombocytosis in a patient treated with ertapenem
European Journal of Case Reports in Internal MedicineErtapenem, a carbapenem-type beta-lactam antibiotic, demonstrates broad-spectrum efficacy against a wide range of Gram-positive and Gram-negative bacteria, including aerobes and anaerobes.
Edward K. Sarfo +3 more
doaj +1 more source
The impact of long-distance mutations on the Ω-loop conformation in TEM type β-lactamases
, 2019 β-lactamases are hydrolytic enzymes primarily responsible for occurrence and abundance of bacteria resistant to β-lactam antibiotics. TEM type β-lactamases are formed by the parent enzyme TEM-1 and more than two hundred of its mutants.
Dmitrii Shcherbinin (6881894) +4 more
core +1 more source
Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries
British Journal of Pharmacology, EarlyView.Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley +1 more source
COMPARACIÓN DE LA PRUEBA TRIDIMENSIONAL CON PCR MÚLTIPLE, PARA DETECCIÓN DE CARBAPENEMASAS
Infectio, 2018 Objective: To compare the phenotypic test for detection of carbapenemases (Three-dimensional Test - THT), with molecular biology test (Multiplex PCR), for the detection of resistance genes.
María Isabel Múnera-Jaramillo
doaj +1 more source