Results 171 to 180 of about 611,430 (255)

Artificial Intelligence to Close the Gap between Pharmacokinetic/Pharmacodynamic Targets and Clinical Outcomes in Critically Ill Patients: A Narrative Review on Beta Lactams. [PDF]

Antibiotics (Basel)
Gonçalves Pereira J, Fernandes J, Mendes T, Gonzalez FA, Fernandes SM.   +4 more
europepmc   +1 more source

Getting It Right the Second Time: How Can we Optimize First‐Generation Cephalosporin Dosing for Skin and Soft Tissue Infections in the 21st Century?

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 7, July 2026.
ABSTRACT Optimal cephalexin and cefadroxil dosing for skin and soft tissue infections (SSTIs) is unclear. We summarize clinical and pharmacokinetic/pharmacodynamic (PK/PD) data that compare dosing strategies for SSTIs. Additionally, we conduct population PK target attainment simulations for varying doses of cephalexin and cefadroxil for Staphylococcus ...
Jonathan H. Ryder, Shawnalyn W. Sunagawa, Nathaniel J. Rhodes, Trevor C. Van Schooneveld, Jeremy E. Tigh, Sean N. Avedissian, Nicolas Cortes‐Penfield   +6 more
wiley   +1 more source

Pharmacokinetic/pharmacodynamic issues for optimizing treatment with beta-lactams of Gram-negative infections in critically ill orthotopic liver transplant recipients: a comprehensive review. [PDF]

Front Antibiot
Gatti M, Pea F.
europepmc   +1 more source

Role of Gram‐Negative Bacterial Infections in Acute‐On‐Chronic Liver Failure

Liver International, Volume 46, Issue 7, July 2026.
ABSTRACT Acute‐on‐chronic liver failure (ACLF) is a systemic disease characterised by an acute clinical deterioration of pre‐existing liver cirrhosis leading to multiple organ failure due to systemic inflammation. It may be triggered by the translocation of bacteria and bacterial compounds across the gut barrier.
Camilla Cadoli, Volker Müller, Christoph Welsch, Heiko Mühl, Jonel Trebicka, Volkhard A. J. Kempf   +5 more
wiley   +1 more source

A whole-cell hypersensitive biosensor for beta-lactams based on the AmpR-AmpC regulatory circuit from the Antarctic Pseudomonas sp. IB20. [PDF]

Microb Biotechnol
Higuera-Llantén S, Alcalde-Rico M, Vasquez-Ponce F, Ibacache-Quiroga C, Blazquez J, Olivares-Pacheco J.   +5 more
europepmc   +1 more source

Strategies Toward Accessing Enantioenriched (Hetero)Benzo‐Fused 5‐ and 6‐ Membered Rings via Intermolecular Carbometalation

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
The use of transition‐metal catalysts and design of chiral ligands have allowed chemists to access highly functionalized benzofused 5‐ and 6‐ membered rings in high yield and enantioselectivity. A common strategy used relies on an intermolecular carbometalation across alkynes and olefins, usually followed by a subsequent intramolecular carbometalation.
Clara Jans, Armaan Grewal, Xavier Abel‐Snape, Mark Lautens   +3 more
wiley   +2 more sources

Electrochemical Sensor Based on Molecularly Imprinted Polymer for Cefuroxime Detection in Biological and Environmental Samples

ChemElectroChem, Volume 13, Issue 12, 17 June 2026.
A highly sensitive electrochemical sensor for cefuroxime (CFR) is developed using a molecularly imprinted PEDOT film integrated with AuNPs and MXene on MWCNT‐SPE. The platform enables selective detection down to nanomolar levels and performs reliably in complex matrices, offering a promising approach for rapid monitoring of antibiotic residues in ...
Houda Essousi, Bogdan Feier, Mihaela Tertis, Maria Suciu, Jassem Wannassi, Houcine Barhoumi, Cecilia Cristea   +6 more
wiley   +1 more source

Antimicrobial susceptibility of enterobacterales causing bloodstream infection in United States medical centres: comparison of aztreonam-avibactam with beta-lactams active against carbapenem-resistant enterobacterales. [PDF]

BMC Infect Dis
Sader HS, Kimbrough JH, Mendes RE, Castanheira M.   +3 more
europepmc   +1 more source