Results 21 to 30 of about 144,132 (182)

Isolation, biochemical characterization, and genome sequencing of two high‐quality genomes of a novel chitinolytic Jeongeupia species

MicrobiologyOpen, Volume 12, Issue 4, August 2023., 2023
In this study, a novel chitinolytic Jeongeupia species “wiesaeckerbachi” was isolated from soil samples, characterized biochemically, and sequenced with the long‐read platform PacBio Sequel IIe. In silico analysis unraveled genomic differences to the closest related type strain Jeongeupia naejangsanensis TAS4‐2 in addition to an usually extensive ...
Nathanael D. Arnold, Daniel Garbe, Thomas B. Brück   +2 more
wiley   +1 more source

Transcriptomic insights into the interplay between polyketide biosynthesis and other secondary metabolite biosynthetic clusters and biological pathways in entomopathogen <i>Beauveria bassiana</i>. [PDF]

Front Microbiol
Background and aimsThe polyketide synthase gene pks15 plays a critical role in insect virulence and cell wall formation in the entomopathogenic fungus Beauveria bassiana.
Toopaang W, Yoocha T, Naktang C, Wichienchote N, Pechsrichuang P, Tangphatsornruang S, Tanticharoen M, Yang YL, Amnuaykanjanasin A.   +8 more
europepmc   +3 more sources

In situ H2O2 Generation by Choline Oxidase and Its Application in Amino Polysaccharide Degradation by Coupling to Lytic Polysaccharide Monooxygenase

ChemBioChem, Volume 24, Issue 14, July 17, 2023., 2023
A proof‐of‐concept study showing that a choline oxidase from Arthrobacter globiformis may be used for fine‐tuned in situ generation of H2O2 to drive and control LPMO‐catalyzed oxidative degradation of chitin. Abstract Chitin, the most abundant amino polysaccharide in Nature, has many applications in different fields.
Nam‐Hai Hoang, Ole Golten, Zarah Forsberg, Vincent G. H. Eijsink, Michael Richter   +4 more
wiley   +1 more source

Humanization for neurological disease modeling: A roadmap to increase the potential of Drosophila model systems

Animal Models and Experimental Medicine, Volume 6, Issue 3, Page 230-236, June 2023., 2023
Graphical abstract reflects the power of Drosophila in modeling human diseases for understanding the disease etiology and drug discovery and validation, as the main goals of the HumanaFly facility of the Faculty of Medicine, University of Geneva. Abstract Neuroscience and neurology research is dominated by experimentation with rodents.
Vladimir L. Katanaev
wiley   +1 more source

Identification of Novel Potential β-N-Acetyl-D-Hexosaminidase Inhibitors by Virtual Screening, Molecular Dynamics Simulation and MM-PBSA Calculations [PDF]

, 2012
Chitinolytic β-N-acetyl-d-hexosaminidases, as a class of chitin hydrolysis enzyme in insects, are a potential species-specific target for developing environmentally-friendly pesticides.
Arai, Arai, Case, Cohen, Essmann, Fukamizo, Gasteiger, Gouda, Guohui Li, Honig, Irwin, Irwin, Jeuniaux, Jianling Liu, Jinan Wang, Keyhani, Koga, Kollman, Kramer, Kuhn, Lee, Liu, Liu, Liu, Medina-Franco, Mengmeng Liu, Morris, Pranav Kumar, Ryckaert, Strasser, Wang, Wang, Watanabe, Weber, Welch, Xu, Yan Li, Yang, Yao Yao, Yi, Yonghua Wang   +40 more
core   +4 more sources

New approaches to Tay-Sachs disease therapy [PDF]

, 2018
Copyright © 2018 Solovyeva, Shaimardanova, Chulpanova, Kitaeva, Chakrabarti and Rizvanov. Tay-Sachs disease belongs to the group of autosomal-recessive lysosomal storage metabolic disorders.
Chakrabarti L., Chulpanova D., Kitaeva K., Rizvanov A., Shaimardanova A., Solovyeva V.   +5 more
core   +5 more sources

Specificity of mouse GM2 activator protein and beta-N-acetylhexosaminidases A and B. Similarities and differences with their human counterparts in the catabolism of GM2.

Journal of Biological Chemistry, 1998
Tay-Sachs disease, an inborn lysosomal disease featuring a buildup of GM2 in the brain, is caused by a deficiency of beta-hexosaminidase A (Hex A) or GM2 activator.
J. Yuziuk, Carmen Bertoni, T. Beccari, Aldo Orlacchio, Yan-Yun Wu, Su-chen Li, Yu-Teh Li   +6 more
semanticscholar   +1 more source

Arabidopsis thaliana alpha1,2-glucosyltransferase (ALG10) is required for efficient N-glycosylation and leaf growth [PDF]

, 2011
Assembly of the dolichol-linked oligosaccharide precursor (Glc3Man9GlcNAc2) is highly conserved among eukaryotes. In contrast to yeast and mammals, little is known about the biosynthesis of dolichol-linked oligosaccharides and the transfer to asparagine ...
Altmann, Friedrich, Farid, Akhlaq, Glössl, Josef, Pabst, Martin, Schoberer, Jennifer, Strasser, Richard   +5 more
core   +2 more sources

Development of unsupervised learning methods with applications to life sciences data [PDF]

, 2023
Machine Learning makes computers capable of performing tasks typically requiring human intelligence. A domain where it is having a considerable impact is the life sciences, allowing to devise new biological analysis protocols, develop patients ...
Gardini, Erika <1994>
core   +1 more source

Proceedings: Isozymes of beta-N-acetylhexosaminidases from normal colonic mucosa and chemically induced rat colonic tumours.

British Journal of Cancer, 1975
Isozymes of β -N-acetylhexosaminidases from normal colonic mucosa and chemically induced rat colonic ...
N. Mian, C. A. Nutman
semanticscholar   +1 more source