Results 81 to 90 of about 1,338,554 (258)
Molecular Metabolism, 2017 Background: Plasma insulin levels are predominantly the product of the morphological mass of insulin producing beta cells in the pancreatic islets of Langerhans and the functional status of each of these beta cells.
Chunguang Chen +4 more
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Synthesis of new α,β-unsaturated butenolides
Bulletin of the Chemical Society of Ethiopia, 2010 A number of new &gama;-substituted α,β-unsaturated butenolides have been synthesized by the condensation of phenols with β-(3-nitrobenzoyl)acrylic acid and β-(4-methyl-3-nitrobenzoyl)acrylic acid.
Veena Joshi, R.P. Chamoli
doaj
Is variation in copy number of the human beta defensin gene cluster associated with preterm birth? [PDF]
, 2015 CP James +7 more
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Experimental investigation of oscillatory flow around circular cylinders at low [beta] numbers.
, 1996 Imperial Users ...
Kühtz, Silvana, Kühtz, Silvana
openaire +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
AIP Advances, 2019 Ion temperature anisotropy is a common feature for (quasi-)perpendicular collisionless shocks. By using two-dimensional full particle simulations, it is shown that the ion temperature component perpendicular to the shock magnetic field at the shock foot ...
Ryo Yamazaki +3 more
doaj +1 more source