Results 181 to 190 of about 384,078 (314)

Bioengineering Platelets Presenting PD‐L1, Galectin‐9 and BTLA to Ameliorate Type 1 Diabetes

Advanced Science, EarlyView.
IFN‐γ‐primed platelets enriched with immunosuppressive ligands (PD‐L1, PD‐L2, BTLA, and Gal‐9) are shown to induce T cell exhaustion and apoptosis, preserving β‐cell function and preventing hyperglycemia progression in type 1 diabetes. IFN‐γ platelets also promote Treg expansion, macrophage polarization, and β‐cell proliferation, offering a promising ...
Yumeng Ma, Fanqiang Meng, Zhongda Lin, Yanjun Chen, Tianyu Lan, Zhaoxin Yang, Rui Diao, Xiaozhou Zhang, Qi Chen, Chi Zhang, Yishi Tian, Chanjuan Li, Wenli Fang, Xin Liang, Xudong Zhang   +14 more
wiley   +1 more source

Osteopenic occult vertebral fracture is associated with poor oncological outcome in patients with hepatocellular carcinoma after hepatic resection

Annals of Gastroenterological Surgery, EarlyView.
Osteopenic occult vertebral fracture (OVF) was associated with poor long‐term outcomes in patients with HCC after hepatic resection. Osteopenic OVF had a poorer prognosis than that of patients with either osteopenia or OVF. Abstract Background Although osteopenia has been associated with poor outcomes in patients with hepatocellular carcinoma (HCC ...
Koichiro Haruki, Kenei Furukawa, Munetoshi Akaoka, Masashi Tsunematsu, Michinori Matsumoto, Tomohiko Taniai, Yoshihiro Shirai, Shinji Onda, Ryoga Hamura, Toru Ikegami   +9 more
wiley   +1 more source

Kaolin clotting time and dilute Russell's viper venom time distinguish between prothrombin-dependent and beta 2-glycoprotein I-dependent antiphospholipid antibodies [PDF]

, 1995
Massimo Galli, Guido Finazzi, EM Bevers, T Barbui   +3 more
openalex   +1 more source

EAE in beta-2 microglobulin-deficient mice: axonal damage is not dependent on MHC-I restricted immune responses

Neurobiology of Disease, 2005
There is accumulating evidence that CD8-positive (CD8+) T-cells and MHC-I expression may also play a role in neurodegeneration associated with multiple sclerosis (MS). We investigated the role of MHC-I and CD8+ T-cells by studying experimental autoimmune
Ralf A. Linker, Evelyn Rott, H.H. Hofstetter, T. Hanke, Klaus V. Toyka, Ralf Gold   +5 more
doaj  

Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives

American Journal of Hematology, EarlyView.
ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley   +1 more source

Unveiling the Potential of Innovative Gold(I) and Silver(I) Selenourea Complexes as Anticancer Agents Targeting TrxR and Cellular Redox Homeostasis

Chemistry – A European Journal, Volume 28, Issue 70, December 15, 2022., 2022
Innovative Au(I) and Ag(I) NHC‐based selenourea complexes exhibit a prominent anticancer effect by selectively targeting TrxR in human cancer cells, thus hampering cancer cell redox machinery and inducing apoptotic cell death. Abstract A series of NHC‐based selenourea Ag(I) and Au(I) complexes were evaluated for their anticancer potential in vitro, on ...
Michele De Franco, Marina Saab, Marina Porchia, Cristina Marzano, Steven P. Nolan, Fady Nahra, Kristof Van Hecke, Valentina Gandin   +7 more
wiley   +1 more source

Phosphatidylserine IgG and beta-2-glycoprotein I IgA antibodies may be a risk factor for ischaemic stroke

, 2005
Timo Kahles, Marek Humpich, Helmuth Steinmetz, Matthias Sitzer, Edelgard Lindhoff‐Last   +4 more
openalex   +1 more source

Site-directed mutagenesis of recombinant human beta 2-glycoprotein I identifies a cluster of lysine residues that are critical for phospholipid binding and anti-cardiolipin antibody activity. [PDF]

, 1996
Yonghua Sheng, A. Sali, Herbert Herzog, J Lahnstein, Steven A. Krilis   +4 more
openalex   +1 more source

Anticardiolipin Antibody Plays a More Important Role Than Anti-β2-Glycoprotein I Antibody in Activating Complement in Patients with Lupus Nephritis

International Journal of General Medicine
Qiankun Zhang,1,2 Zhuoqin Ren,3– 5 Jie Li,1,2 Zhengping Zou3– 5 1Department of Nephrology, the Fifth Affiliated Hospital of Wenzhou University, Lishui, Zheiang, People’s Republic of China; 2Department of Nephrology, Lishui Central Hospital, Lishui ...
Zhang Q, Ren Z, Li J, Zou Z
doaj  

Effect of hormone replacement therapy on total serum anti-oxidant potential and oxidized LDL/.BETA.2-glycoprotein I complexes in postmenopausal women

, 2010
Maryam Darabi, Mohsen Ani, Ahmad Movahedian, Elahe Zarean, Mojtaba Panjehpour, Mohammad Rabbani   +5 more
openalex   +2 more sources