Results 181 to 190 of about 88,568 (304)
The Journal of Physiology, EarlyView.Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani +5 more
wiley +1 more source
Concomitant Diabetes and Atrial Fibrillation: Epicardial Fat and Macrophage‐Related Mechanisms
Diabetes/Metabolism Research and Reviews, Volume 41, Issue 5, July 2025.ABSTRACT Type 2 diabetes mellitus (T2DM) is present in 25% of patients with atrial fibrillation (AF), the most prevalent arrhythmia in the world. This concomitant disorder enhances thromboembolic events, length of hospital stay after AF ablation, renal impairment after anticoagulation, heart rate variability after glucose‐lowering treatment, and ...
Saja Al‐rubaye +3 more
wiley +1 more source
MedComm, Volume 6, Issue 7, July 2025.TET family proteins play a critical role in DNA demethylation, and their mutations and dysregulation contribute to the onset of multiple diseases. With a deeper understanding of the molecular mechanisms of TET involvement in disease, drug therapy targeting TET proteins shows great potential, which provides insights into new therapeutic strategies ...
Junzhi Liang +12 more
wiley +1 more source
The Interplay of Cross‐Organ Immune Regulation in Inflammation and Cancer
MedComm, Volume 6, Issue 7, July 2025.Organs interact dynamically through immune regulation, influencing systemic immune responses and disease progression. We review molecular and cellular mechanisms of cross‐organ immune regulation in inflammation and cancer, focusing on gut, liver, and brain interactions with other organs.
Jie Dou +6 more
wiley +1 more source
Macrophage Signaling Pathways in Health and Disease: From Bench to Bedside Applications
MedComm, Volume 6, Issue 7, July 2025.Macrophage functions in phagocytosis, tissue repair, immune regulation, and neuronal network protection. And graphic abract image in the attachment. ABSTRACT Macrophages exhibit remarkable functional plasticity by dynamically polarizing into proinflammatory or antiinflammatory subsets in response to microenvironmental cues. This duality underpins their
Yongquan Chi +6 more
wiley +1 more source
Light‐Activated Pharmacological Tools for Exploring the Cholinergic System
Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni +5 more
wiley +1 more source
Acta Physiologica, Volume 241, Issue 7, July 2025.ABSTRACT Background and Aims The development of innovative strategies to treat diabesity and its comorbidities is of major societal importance. The carotid bodies (CB), classically defined as O2 sensors, are also metabolic sensors whose dysfunction contributes to the genesis and progression of metabolic disturbances. Here, we tested the hypothesis that
Bernardete F. Melo +14 more
wiley +1 more source
British Journal of Pharmacology, Volume 182, Issue 14, Page 3044-3067, July 2025.Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi +6 more
wiley +1 more source