Results 201 to 210 of about 24,989 (236)
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Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase
Nature, 1986The structural components involved in transduction of extracellular signals as diverse as a photon of light impinging on the retina or a hormone molecule impinging on a cell have been highly conserved. These components include a recognition unit or receptor (for example, the beta-adrenergic receptor (beta AR) for catecholamines or the 'light receptor ...
J L, Benovic +4 more
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Functional consequences of A1 adenosine-receptor phosphorylation by the β-adrenergic receptor kinase
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1993Treatment of smooth-muscle cells with R-phenylisopropyladenosine (R-PIA) leads to a loss of A1 adenosine receptor (A1AR)-mediated inhibition of adenylate cyclase, a decrease in receptor number and an increase in receptor phosphorylation. In this study, the role of the beta-adrenergic receptor kinase (beta ARK) in the phosphorylation and inactivation of
V, Ramkumar +4 more
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American Journal of Physiology-Heart and Circulatory Physiology, 1997
To determine the direct functional significance of the beta-adrenergic receptor (AR) kinase 1 (beta ARK1) on myocardial performance in the absence of tonic sympathoadrenal neural activation and mechanical loading, we measured the contractile responses to acute beta 1-AR stimulation in left ventricular myocytes isolated from nontransgenic control (NTG)
D H, Korzick +5 more
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To determine the direct functional significance of the beta-adrenergic receptor (AR) kinase 1 (beta ARK1) on myocardial performance in the absence of tonic sympathoadrenal neural activation and mechanical loading, we measured the contractile responses to acute beta 1-AR stimulation in left ventricular myocytes isolated from nontransgenic control (NTG)
D H, Korzick +5 more
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Comparative Analysis of β-Adrenergic Receptor Kinase and β-Arrestin mRNA Expression in Human Cells
Journal of Receptor Research, 1993Receptor phosphorylation is a key step in the process of rapid desensitization. beta-Adrenergic receptor kinase is a specific receptor kinase that is known to phosphorylate and induce desensitization of several G-coupled synaptic receptors only when they are occupied by their agonists.
Parruti G +3 more
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Biochemical and Biophysical Research Communications, 1993
In the present study the cDNA of human beta ARK2 was cloned using both PCR and cDNA library screening, subcloned into an expression vector and transiently expressed in COS7 cells. The expressed kinase activity was approximately 40% as efficient as human beta ARK1 in phosphorylating bovine rod outer segments in vitro. Northern blot analysis of human and
Parruti G +3 more
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In the present study the cDNA of human beta ARK2 was cloned using both PCR and cDNA library screening, subcloned into an expression vector and transiently expressed in COS7 cells. The expressed kinase activity was approximately 40% as efficient as human beta ARK1 in phosphorylating bovine rod outer segments in vitro. Northern blot analysis of human and
Parruti G +3 more
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Serum creatine kinase release and alpha- and beta-adrenergic receptors.
Archives internationales de pharmacodynamie et de therapie, 1986Changes in the serum creatine kinase (CK) activity and the mechanism of its release after administration of two kinds of beta-blockers to rats were studied in order to determine the mechanism of the increase in serum CK accompanying administration of beta-blockers.
Y, Jingu, Y, Aoki, H, Itoh, T, Saruta
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Carondiac G-Protein Receptor Kinase Activity: Effect of a β-Adrenergic Receptor Antagonist
1997Publisher Summary This chapter presents a summary of the data that test the hypothesis that β -adrenergic receptor ( β AR) activation affects G-protein receptor kinase (GRK) activity in the heart. Data reported in the chapter have been previously published. The chapter has attempted to summarize the key features of this publication. Selected figures
H K, Hammond, P, Ping, P A, Insel
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