Results 91 to 100 of about 1,706,661 (335)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Determinants of Blank and Null Votes in the Brazilian Presidential Elections

Stats
This study analyzes the factors influencing the proportions of blank and null votes in Brazilian municipalities during the 2018 presidential elections.
Renata Rojas Guerra, Kerolene De Souza Moraes, Fernando De Jesus Moreira Junior, Fernando A. Peña-Ramírez, Ryan Novaes Pereira   +4 more
doaj   +1 more source

A Generalization of Generalized Beta Distributions [PDF]

Finance and Economics Discussion Series, 1998
This paper introduces the "compound confluent hypergeometric" (CCH) distribution. The CCH unifies and generalizes three recently introduced generalizations of the beta distribution: the Gauss hypergeometric (GH) distribution of Armero and Bayarri (1994), the generalized beta (GB) distribution of McDonald and Xu (1995), and the
openaire   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Incremental Beta Distribution Weighted Fuzzy C-Ordered Means Clustering

Information
Streaming data is becoming more and more common in the field of big data and incremental frameworks can address its complexity. The BDFCOM algorithm achieves good results on common form datasets by introducing the ordering mechanism of beta distribution ...
Hengda Wang, Mohamad Farhan Mohamad Mohsin, Muhammad Syafiq Mohd Pozi, Zhu Zeng   +3 more
doaj   +1 more source

The Beta-Hyperbolic Secant (BHS) Distribution [PDF]

The shape of a probability distribution is often summarized by the distribution's skewness and kurtosis. Starting from a symmetric parent density f on the real line, we can modify its shape (i.e.
Fischer, Matthias J., Vaughan, David
core  

The Modified Beta Weibull Distribution [PDF]

Hacettepe Journal of Mathematics and Statistics, 2014
A new five-parameter model called the modified beta Weibull probability distribution is being introduced in this paper. This model turnsout to be quite flexible for analyzing positive data and has bathtub andupside down bathtub hazard rate function.Our main objectives are to obtain representations of certain statisticalfunctions and to estimate the ...
openaire   +2 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Product and Quotient of Independent Gauss Hypergeometric Variables

Ingeniería y Ciencia, 2011
In this article, we have derived the probability density functions of the productand the quotient of two independent random variables having Gauss hypergeometricdistribution.
Daya Krishna Nagar, Danilo Bedoya Valencia   +1 more
doaj