Results 71 to 80 of about 772,266 (306)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

SOLVING ASSIGNMENT PROBLEM WITH LINGUISTIC COSTS

Journal of New Theory, 2017
– The purpose of this paper is to solve an assignment problem with linguistic costs/ times. In this paper, an assignment problem has been considered whose costs/times relating to the problem are linguistic variables and its solution methodology has been ...
Laxminarayan Sahoo, Santanu Kumar Ghosh
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The polarized expression of Na+,K+-ATPase in epithelia depends on the association between beta-subunits located in neighboring cells [PDF]

, 2005
The polarized distribution of Na+,K+-ATPase plays a paramount physiological role, because either directly or through coupling with co- and countertransporters, it is responsible for the net movement of, for example, glucose, amino acids, Ca2+, K+, Cl ...
Shoshani, L, Balda, MS, Cereijido, M, Matter, K, Moreno, J, Contreras, RG, Roldan, ML, Lazaro, A   +7 more
core  

Regional and global changes in TCR [alpha][beta] T cell repertoires in the gut are dependent upon the complexity of the enteric microflora [PDF]

, 2010
The repertoire of gut associated T cells is shaped by exposure to microbes, including the natural enteric microflora. Previous studies compared the repertoire of gut associated T cell populations in germ free (GF) and conventional mammals often focussing
Beal, R.K., Smith, A.L., Tom Humphrey, Friedman, A., Friedman, A, Beal, RK, Bailey, M, Adrian L. Smith, Humphrey, T., Claire Powers, Wu, X, Bailey, M., William N. Mwangi, Mwangi, WN, Smith, Adrian, Watson, M, Xikun Wu, Mwangi, W.N., Richard K. Beal, Michael Watson, Humphrey, TJ, Wu, X., Humphrey, T, Watson, Mick, Smith, AL, Aharon Friedman, Powers, C, Powers, C., Michael Bailey   +28 more
core   +1 more source

Fish-Ecology-Lab/dolphinfish: Beta version [PDF]

, 2020
A beta version for the theoretical temperature-dependent hatch date distribution from biased samples ...
Andres Ospina-Alvarez
core   +1 more source

A Generalization of Generalized Beta Distributions [PDF]

Finance and Economics Discussion Series, 1998
This paper introduces the "compound confluent hypergeometric" (CCH) distribution. The CCH unifies and generalizes three recently introduced generalizations of the beta distribution: the Gauss hypergeometric (GH) distribution of Armero and Bayarri (1994), the generalized beta (GB) distribution of McDonald and Xu (1995),
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source