Results 61 to 70 of about 6,189,777 (260)
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
The Beta-Hyperbolic Secant (BHS) Distribution [PDF]
The shape of a probability distribution is often summarized by the distribution's skewness and kurtosis. Starting from a symmetric parent density f on the real line, we can modify its shape (i.e.
Fischer, Matthias J., Vaughan, David
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Beta Distribution Weighted Fuzzy C-Ordered-Means Clustering
Journal of ICTThe fuzzy C-ordered-means clustering (FCOM) is a fuzzy clustering algorithm that enhances robustness and clustering accuracy through the ordered mechanism based on fuzzy C-means (FCM).
Hengda Wang +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A Nested Test for Common Yield Distributions with Applications to U.S. Corn
Journal of Agricultural and Resource Economics, 2013 We propose the use of maximum-entropy techniques to nest and test the functional form of commonly used yield densities. We demonstrate how common parametric yield models can be nested within a maximum-entropy framework and subsequently tested for using ...
Jesse Tack
doaj +1 more source
Something New, Something Old: Parametric Models for the Size of Distribution of Income
, 1997 Two new probability density functions (generalized beta and quadratic elasticity) are considered as models for the size distribution of income. The generalized beta distribution nests the generalized beta of the first and second kind, generalized gamma ...
McDonald, James B. +2 more
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Determinants of Blank and Null Votes in the Brazilian Presidential Elections
StatsThis study analyzes the factors influencing the proportions of blank and null votes in Brazilian municipalities during the 2018 presidential elections.
Renata Rojas Guerra +4 more
doaj +1 more source