Results 91 to 100 of about 13,948,536 (305)
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Logarithmic correction in the deformed AdS(5) model to produce the heavy quark potential and QCD beta function [PDF]
, 2010 We study the holographic QCD model, which contains a quadratic term -{sigma}z{sup 2} and a logarithmic term -c{sub 0}log[(z{sub IR}-z)/z{sub IR}] with an explicit infrared cutoff z{sub IR} in the deformed AdS{sub 5} warp factor.
Song He, Mei Huang, Q. Yan
semanticscholar +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Genes & Development, 1994 In the last 10 years, a large family of secreted signaling molecules has been discovered that appear to mediate many key events in normal growth and development.
D. Kingsley
semanticscholar +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Generalized Bivariate Kummer-Beta Distribution
Ingeniería y Ciencia, 2020 A new bivariate beta distribution based on the Humbert’s confluent hypergeometric function of the second kind is introduced. Various representations are derived for its product moments, marginal densities, marginal moments, conditional densities and ...
Daya K. Nagar +2 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Derivatives of the Incomplete Beta Function
Journal of Statistical Software, 1998 The incomplete beta function is defined as where Beta(p, q) is the beta function. Dutka (1981) gave a history of the development and numerical evaluation of this function. In this article, an algorithm for computing first and second derivatives of Ix,p,q
James F. Robison-Cox, Robert J. Boik
doaj +3 more sources