Results 81 to 90 of about 13,948,536 (305)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Some inequalities involving two generalized beta functions in n variables

Journal of Inequalities and Applications, 2021
The beta and gamma functions have recently seen several developments and various extensions because of their nice properties and interesting applications. The contribution of this paper falls within this framework.
Mustapha Raïssouli, Salma I. El-Soubhy
doaj   +1 more source

Verapamil and beta cell function in adults with recent-onset type 1 diabetes

Nature Medicine, 2018
Pancreatic beta cell loss is a key factor in the pathogenesis of type 1 diabetes (T1D), but therapies to halt this process are lacking. We previously reported that the approved antihypertensive calcium-channel blocker verapamil, by decreasing the ...
F. Ovalle, T. Grimes, Guanlan Xu, Anishi Patel, T. Grayson, L. Thielen, Peng Li, A. Shalev   +7 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Exact Expressions for Kullback–Leibler Divergence for Univariate Distributions

Entropy
The Kullback–Leibler divergence (KL divergence) is a statistical measure that quantifies the difference between two probability distributions. Specifically, it assesses the amount of information that is lost when one distribution is used to approximate ...
Victor Nawa, Saralees Nadarajah
doaj   +1 more source

Quantum gravitational contributions to the beta function of quantum electrodynamics [PDF]

, 2011
We show in a diagrammatic and regularization independent analysis that the quadratic contribution to the beta function which has been conjectured to render quantum electrodynamics asymptotically free near the Planck scale has its origin in a surface term.
J. Felipe, L. Brito, M. Sampaio, M. Nemes   +3 more
semanticscholar   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.

Cell, 2010
Alzheimer's disease (AD) is characterized by amyloid-beta (Abeta) and tau deposition in brain. It has emerged that Abeta toxicity is tau dependent, although mechanistically this link remains unclear. Here, we show that tau, known as axonal protein, has a
L. Ittner, Y. Ke, F. Delerue, Mian Bi, Amadeus Gladbach, Janet van Eersel, Heidrun Wölfing, B. Chieng, M. Christie, I. Napier, A. Eckert, M. Staufenbiel, Edna Hardeman, J. Götz   +13 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Certain Properties Associated with Generalized $M$-Series using Hadamard Product [PDF]

Sahand Communications in Mathematical Analysis
The generalized $M$-series is a hybrid function of generalized Mittag-Leffler function and generalized hypergeometric function.  The principal aim of this paper is to investigate certain properties resembling those of the Mittag-Leffler and ...
Dheerandra Sachan, Dinesh Kumar, Kottakkaran Nisar   +2 more
doaj   +1 more source