Results 21 to 30 of about 386,471 (257)

In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse. [PDF]

PLoS ONE, 2010
BACKGROUND: TGF-beta has been postulated to play an important role in the maintenance of epithelial homeostasis and the development of epithelium-derived cancers.
Xiaolin Luo, Qiurong Ding, Min Wang, Zhigang Li, Kairui Mao, Bing Sun, Yi Pan, Zhenzhen Wang, Ying Qin Zang, Yan Chen   +9 more
doaj   +1 more source

Exact Expressions for Kullback–Leibler Divergence for Multivariate and Matrix-Variate Distributions

Entropy
The Kullback–Leibler divergence is a measure of the divergence between two probability distributions, often used in statistics and information theory. However, exact expressions for it are not known for multivariate or matrix-variate distributions apart ...
Victor Nawa, Saralees Nadarajah
doaj   +1 more source

ECM-enriched alginate hydrogels for bioartificial pancreas: an ideal niche to improve insulin secretion and diabetic glucose profile

Journal of Applied Biomaterials & Functional Materials, 2019
Introduction: The success of a bioartificial pancreas crucially depends on ameliorating encapsulated beta cells survival and function. By mimicking the cellular in vivo niche, the aim of this study was to develop a novel model for beta cells ...
Joana Crisóstomo, Ana M Pereira, Sílvia J Bidarra, Ana C Gonçalves, Pedro L Granja, Jorge FJ Coelho, Cristina C Barrias, Raquel Seiça   +7 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Matrix transformations of Norlund–Orlicz difference sequence spaces of nonabsolute type and their Toeplitz duals

Advances in Difference Equations, 2020
In this paper, the Nörlund–Orlicz difference sequence space N t ( F , Δ n m , u , q ) $\mathcal{N}^{t}(\mathcal{F},\Delta^{m}_{n},u,q)$ of nonabsolute type is introduced as a domain of Nörlund means which is isomorphic to the space ℓ ( p ) $\ell(p)$ and ...
Adem Kılıçman, Kuldip Raj
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Operator mixing in massless QCD-like theories and Poincarè–Dulac theorem

European Physical Journal C: Particles and Fields, 2022
Recently, a differential-geometric approach to operator mixing in massless QCD-like theories – that involves canonical forms, obtained by means of gauge transformations, based on the Poincarè–Dulac theorem for the system of linear differential equations ...
Matteo Becchetti, Marco Bochicchio
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source