Results 41 to 50 of about 386,471 (257)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
PLoS ONE, 2009 During development, growth factors and hormones cooperate to establish the unique sizes, shapes and material properties of individual bones. Among these, TGF-beta has been shown to developmentally regulate bone mass and bone matrix properties.
Khalid S Mohammad +17 more
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Choice of 16S ribosomal RNA primers affects the microbiome analysis in chicken ceca
Scientific Reports, 2021 We evaluated the effect of applying different sets of 16S rRNA primers on bacterial composition, diversity, and predicted function in chicken ceca. Cecal contents from Ross 708 birds at 1, 3, and 5 weeks of age were collected for DNA isolation.
Nadia Darwish +3 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Higher order constraints for the ( $$\beta $$ β -deformed) Hermitian matrix models
European Physical Journal C: Particles and FieldsWe construct the ( $$\beta $$ β -deformed) higher order total derivative operators and analyze their remarkable properties. In terms of these operators, we derive the higher order constraints for the ( $$\beta $$ β -deformed) Hermitian matrix models.
Rui Wang
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Pinning down the strength function for ordinary muon capture on 100Mo
Physics Letters B, 2019 Ordinary muon capture (OMC) on 100Mo is studied both experimentally and theoretically in order to access the weak responses in wide energy and momentum regions. The OMC populates states in 100Nb up to some 50 MeV in excitation energy.
L. Jokiniemi +3 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The nullity of the net Laplacian matrix of a signed graph
The American Journal of CombinatoricsThe net Laplacian matrix of a signed graph \(\Gamma = (G, \sigma)\), where \(G = (V(G),E(G))\) is an unsigned graph (referred to as the underlying graph) and \(\sigma: E(G) \rightarrow \{-1, +1\}\) is the sign function, is defined as \(L^{\pm}(\Gamma) =
Zhuang Xiong
doaj +1 more source