Results 31 to 40 of about 386,471 (257)

Classical special functions of matrix arguments

Sistemnì Doslìdženâ ta Informacìjnì Tehnologìï
This article focuses on a few of the most commonly used special functions and their key properties and defines an analytical approach to building their matrix-variate counterparts.
Dmytro Shutiak, Gleb Podkolzin, Victor Bondarenko, Yury Chapovsky   +3 more
doaj   +1 more source

Coupling integrin dynamics to cellular adhesion behaviors

Biology Open, 2018
Visualizing fluorescent proteins is essential for understanding cellular function. While advances in microscopy can now resolve individual molecules, determining whether the labeled molecules report native behaviors and how the measured behaviors can be ...
Catherine G. Galbraith, Michael W. Davidson, James A. Galbraith   +2 more
doaj   +1 more source

Fibrotic myofibroblasts manifest genome-wide derangements of translational control. [PDF]

PLoS ONE, 2008
BACKGROUND:As a group, fibroproliferative disorders of the lung, liver, kidney, heart, vasculature and integument are common, progressive and refractory to therapy. They can emerge following toxic insults, but are frequently idiopathic.
Ola Larsson, Deanna Diebold, Danhua Fan, Mark Peterson, Richard Seonghun Nho, Peter B Bitterman, Craig A Henke   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Type-1 Beta Distribution and its Connections to Likelihood Ratio Test

Statistica
In many cases involving hypothesis testing for parameters in multivariate Gaussian populations and certain other populations, likelihood ratio criteria, or their one-to-one functions, can be expressed in terms of the determinant of a real type-1 beta ...
Nicy Sebastian, T. Princy
doaj   +1 more source

Informed Weighted Non-Negative Matrix Factorization Using αβ-Divergence Applied to Source Apportionment

Entropy, 2019
In this paper, we propose informed weighted non-negative matrix factorization (NMF) methods using an α β -divergence cost function.
Gilles Delmaire, Mahmoud Omidvar, Matthieu Puigt, Frédéric Ledoux, Abdelhakim Limem, Gilles Roussel, Dominique Courcot   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source