Results 61 to 70 of about 1,044,930 (284)

Rare double heterozygosity for poly A(A>G) and CD17(A>T) of beta thalassemia intermedia in a Chinese family

Hematology Reports, 2019
Beta thalassemia is a hereditary disorder resulted from mutations in the β globin gene leading to alpha/beta imbalance, ineffective erythropoiesis, and chronic anemia.
Jianhong Xie, Yuqiu Zhou, Qizhi Xiao, Ruoting Long, Lianxiang Li, Lei Li   +5 more
doaj   +1 more source

Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia

Haematologica, 2016
Beta-thalassemia is one of the most frequently inherited disorders caused by mutations in the beta globin gene or its promoter, leading to reduced or absent beta globin synthesis.
C. Casu, M. Aghajan, Paraskevi Rea Oikonomidou, Shuling Guo, B. Monia, S. Rivella   +5 more
semanticscholar   +1 more source

Applying the National Genomic DNA Reference Materials to Evaluate the Performance of Nanopore Sequencing in Identifying Thalassemia Variants

Journal of Clinical Laboratory Analysis, EarlyView.
This study mainly to evaluate the performance of nanopore technology in thalassemia detection by utilizing the national genomic reference materials in China. We proved that the reference materials can be used to evaluate the performance of nanopore sequencing in identifying thalassemia mutations, and it's necessary to incorporate triplicates when ...
Xingyu Wei, Xu Yang, Wanqing Han, Li Zhang, Guojun Ouyang, Shoufang Qu, Fang Yang, Xuexi Yang   +7 more
wiley   +1 more source

Classification of β-Thalassemia Carriers From Red Blood Cell Indices Using Ensemble Classifier

IEEE Access, 2021
Thalassemia is viewed as a prevalent inherited blood disease that has gotten exorbitant consideration in the field of medical research around the world. Inherited diseases have a high risk that children will get these diseases from their parents. If both
Saima Sadiq, Muhammad Usman Khalid, Mui-Zzud-Din, Saleem Ullah, Waqar Aslam, Arif Mehmood, Gyu Sang Choi, Byung-Won On   +7 more
doaj   +1 more source

Novel Meta-Heuristic Model for Discrimination between Iron Deficiency Anemia and B-Thalassemia with CBC Indices Based on Dynamic Harmony Search [PDF]

arXiv, 2020
In recent decades, attention has been directed at anemia classification for various medical purposes, such as thalassemia screening and predicting iron deficiency anemia (IDA). In this study, a new method has been successfully tested for discrimination between IDA and \b{eta}-thalassemia trait (\b{eta}-TT).
arxiv  

Premature atherosclerosis in children with beta-thalassemia major: New diagnostic marker

BMC Pediatrics, 2017
BackgroundEarly vascular alteration, atherosclerosis and coronary artery disease have emerged as important cardiovascular complications among beta-thalassemia major (B-TM) patients. The aims of the current study were to assess the prevalence of premature
L. Sherief, Osama Dawood, Adel S A Ali, H. Sherbiny, N. Kamal, Mohamed Elshanshory, Osama Abd Alazez, M. A. Alhady, M. Nour, Wesam A. Mokhtar   +9 more
semanticscholar   +1 more source

Treatment Experience Using a Micro‐Induction Buprenorphine Protocol for Chronic Pain in Pediatric Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Patients with sickle cell disease (SCD) experience painful vaso‐occlusive episodes that increase with age; a subset develops chronic pain (CP). CP is usually managed with acute pain management guidelines despite evidence of ineffectiveness.
Ashwin Patel, Grace Kalmus, Carlton Dampier, Ifeyinwa Osunkwo, Tamara New, Beatrice Gee, Elna Saah   +6 more
wiley   +1 more source

Prevalence of Co-Inheritance of Alpha-Thalassemia with Beta-Thalassemia and Beta-Hemoglobinopathy in Ahvaz City

Journal of Ardabil University of Medical Sciences, 2013
Background: Co-inheritance of hemoglobin gene defects is a rare important status that can lead to double heterozygote or homozygote with significant clinical manifestations. Such conditions can be observed in co-inheritance of alpha-thalassemia with beta-
Najmaddin Saki, Akbar Dorgalaleh, Zahra Kashani Khatib, Shaban Alizadeh, Fakher Rahim, Hamid Galehdari, Bijan Kaikhaei, Mohammad Pedram, Ali Dehghani Fard   +8 more
doaj  

Beta thalassemia - a review

Journal of Pathology of Nepal, 2014
Thalassemia is a globin gene disorder that results in a diminished rate of synthesis of one or more of the globin chains. About 1.5% of the global population (80 to 90 million people) are carriers of beta Thalassemia.
R Jha, S Jha
doaj   +1 more source

Effect of zinc supplementation on serum mlondealdehyde and lipid profiles on beta thalassemia major patients [PDF]

, 2012
Objectives: Thalassemic patients are seriously at risk of serum dislipidemia, zinc deficiency and tissue damage due to oxidative stress induced by iron storage.
Aboomardani, M., Arefhosseini, R., Rafraf, M., Rashidi, M.R.   +3 more
core