Objectives: To assess the sensitivity of the various discrimination indicesas screening test in beta-thalassemia trait patients in our population. Study design: Crosssectional descriptive study. Period: 1-Sep 2012 to 31-Jan 2013 (5 months). Settings: PathologyDepartment, District Head Quarters (DHQ) Hospital, Rawalpindi.
Muhammad Ihtesham Khan +2 more
openaire +4 more sources
Serum Transferrin Receptor Levels in Beta-thalassemia Trait [PDF]
Increased levels of transferrin receptors (TfR) and soluble TfR (sTfR) are reliable indicators of iron deficiency anemia and conditions with enhanced erythropoietic activity. In this study we measured sTfR levels in the cases of beta-thalassemia trait (betaTT) and IDA to see whether it would be a diagnostic tool for the differentiation of betaTT and ...
Demir, A +4 more
openaire +4 more sources
Genetic and Clinical Characteristics of Thalassemia Trait and Construction of LASSO-Based Model for Its Differentiating From Iron Deficiency Anemia in Northern China. [PDF]
This study revealed a β‐thalassemia‐trait‐dominated genetic spectrum in Northern‐Chinese patients with microcytic hypochromic anemia, with _αSEA/αα, HBB:c.316_197C>T and HBB:c.124_127delTTCT being the most prevalent α‐ and β‐globin genotypes. Using LASSO regression, we constructed a nomogram based on four routine complete‐blood‐count parameters (RBC ...
Yu WJ +6 more
europepmc +2 more sources
Discriminant Indices for Screening Beta Thalassemia Trait: An Illusion of Choice. [PDF]
Kakkar N, Sharma A.
europepmc +3 more sources
Beta-thalassemia trait: an underrecognized risk for osteoporosis in postmenopausal women, warranting screening. [PDF]
This case series presents two postmenopausal women with beta-thalassemia trait who developed osteoporosis. Case 1 involves a woman in her 70s presenting with persistent lower back pain; imaging revealed a compression fracture at L2, and a DEXA scan ...
Alipuria P, Alipuria A.
europepmc +2 more sources
Behind the splenomegaly: a parasitic twist in siblings with beta thalassemia trait. [PDF]
BACKGROUND: Thalassemia syndromes are characterized by varying degrees of ineffective hematopoiesis and increased hemolysis. β-thalassemia trait typically presents as mild microcytic anemia and rarely with significant clinical findings such as splenomegaly.
Ali A +4 more
europepmc +3 more sources
Receptor Activator of Nuclear Factor kappa-Beta Ligand/Osteoprotegerin Axis in Adults with Hb S/beta-Thalassemia and beta-Thalassemia Trait [PDF]
There is not enough data about osteoporosis and the role of receptor activator of nuclear factor kappa-Beta ligand (RANKL)/serum osteoprotegerin (OPG) system in patients with double heterozygosity for sickle cell disease and beta-thalassemia [Hb S (HBB ...
Tombak, Anil +4 more
core +1 more source
FREQUENCY OF BETA THALASSEMIA TRAIT AMONG THE HEALTHY INDIVIDUALS - A SINGLE CENTRE STUDY
Objective: To determine the frequency of beta thalassemia trait among the asymptomatic healthy individuals. Study Design: Cross sectional study. Place and Duration of Study: This was carried out at Pakistan Air Force (PAF) Hospital Lahore from ...
Muhammad Arif Sadiq +3 more
doaj +4 more sources
Graves' disease mimicking beta-thalassemia trait [PDF]
Summary A case of Graves' disease associated with splenomegaly, lymphadenopathy, microcytic hypochromic anaemia, and a raised haemoglobin A2 is presented. The haematological indices returned to normal after conventional treatment with anti-thyroid medication.
openaire +2 more sources
How early can myocardial iron overload occur in Beta thalassemia major? [PDF]
BACKGROUND: Myocardial siderosis is the most common cause of death in patients with beta thalassemia major(TM). This study aimed at investigating the occurrence, prevalence and severity of cardiac iron overload in a young Chinese population with beta TM.
Gaohui Yang +34 more
core +2 more sources

