Results 31 to 40 of about 1,157,565 (202)

Venous thromboembolism risk assessment among beta-thalassemia patients

Journal of Applied Hematology, 2023
BACKGROUND: Thromboembolic (TE) disorders are among the most common complications of beta-thalassemia. We designed this cross-sectional study to investigate the state of hypercoagulability and platelet activation in patients with beta-thalassemia ...
Hasnaa A Abo-Elwafa, Laila M Youseff, Ramadan A Mahmoud, Mahmoud I Elbadry, Ahmed Tawfeek, Shereen P Aziz   +5 more
doaj   +1 more source

Structural and functional characterization of CSDA protein complexes involved in the modulation of fetal globin gene expression [PDF]

, 2009
Impaired switching from fetal hemoglobin (HbF) to adult globin gene expression leads to hereditary persistence of fetal hemoglobin (HPFH) in adult life.
Gaudino, Sara
core   +1 more source

Association Between Thalassemia and Leucocytic DNA Damage: A Pilot Study

Journal of Basic and Applied Research in Biomedicine, 2022
Objectives: Thalassemia with frequent blood transfusion was considered under oxidative stress because of the chance of iron overload. Patients with thalassemia trait with no blood transfusion might also suffered from oxidative stress because of ...
Yim Szeto, Charlton CHAN
doaj   +2 more sources

Development and Validation of a Nomogram Based on Red Blood Cell and Reticulocyte Parameters for Differentiating Thalassemia Trait From Iron Deficiency Anemia. [PDF]

J Clin Lab Anal
Thalassemia trait (TT) and iron deficiency anemia (IDA) are the primary causes of microcytic hypochromic anemia with overlapping hematological features, making their differential diagnosis challenging, so this study developed and validated a nomogram integrating red blood cell (RBC) count, mean corpuscular volume (MCV), reticulocyte percentage (RET ...
Chen Y, Mao Y, Liu J, Lin Y, Chen D.
europepmc   +2 more sources

Pattern of hemoglobinopathies and thalassemias in upper Assam region of North Eastern India: High performance liquid chromatography studies in 9000 patients

Indian Journal of Pathology and Microbiology, 2014
Background: The hereditary hemoglobin (Hb) disorders are the most commonly encountered single gene disorders in India. Data pertaining to the pattern of hemoglobinopathies and thalassemias is scarce in North East India, and hence it was considered ...
Mrinal Kumar Baruah, Malavika Saikia, Aditi Baruah   +2 more
doaj   +1 more source

Type and frequency of hemoglobinopathies, diagnosed in the area of Karachi, in Pakistan

Cogent Medicine, 2016
Hemoglobinopathies are one of the major problems in Pakistan. A retrospective analysis of blood samples of 2731 patients from 2010 to 2014 was done at National Institute of Blood Disease & Bone Marrow Transplantation for the workup of anemia or other ...
Shaista Shabbir, Muhammad Nadeem, Abdul Sattar, Iffat Ara, Saqib Ansari, Tassneem Farzana, Mehwish Taj, Munira Borhany, Saima Manzir, Uzma Zaidi, Jawad Hassan, Arshi Naz, Tahir Shamsi   +12 more
doaj   +1 more source

Systemic lupus erythematosus and beta-thalassemia trait

APIK Journal of Internal Medicine, 2020
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that predominantly affects women of child-bearing age. The prevalence of beta-thalassemia in patients with SLE is lesser than the general population. When these two conditions coexist, however, SLE seems to have a more severe course.
M Narayana Swamy, T A Shilpa, Stephen Benny   +2 more
openaire   +2 more sources

Phenotypic and Genotypic Analysis of Two Rare Cases of ‐‐SEA/‐α4.3 HbH Disease

Journal of Clinical Laboratory Analysis, EarlyView.
We report two unrelated adult patients with rare deletional HbH disease (genotype ‐‐SEA/‐α4.3). This novel 4.3 kb deletion covering the HBA1 gene is accompanied by X‐Y‐Z segment recombination, which was identified by CycloneSEQ long‐read nanopore sequencing.
Weijia Yang, Xiaoyan Huang, Li Zhang, Xiaoqin Yang, Yaya Guo, Qingping Kang, Min Dou, Guijun Huang   +7 more
wiley   +1 more source

NESTROFT AS SCREENING TEST FOR BETA THALASSEMIA TRAIT

PARIPEX INDIAN JOURNAL OF RESEARCH, 2020
Objective: To evaluate the utility of NESTROFT as a screening test for Beta Thalassemia Trait. Material and Methods: A Prospective study of total 137 clinically normal siblings of thalassemia major patients registered at thalassemia clinic in department of pediatrics, Govt. medical college, Kota were selected randomly for the study.
Keshav Bansal, Dhaval Bhatt, G.K. Sharma
openaire   +1 more source

Identification of Delta-beta Thalassemia in a Family with Elevated Hb F: A Case Report [PDF]

Journal of Krishna Institute of Medical Sciences University, 2020
Delta-beta Thalassemia is a rare variant of thalassemia with elevated Hb F. Heterozygous and homozygous state of delta-beta thalassemia present with features similar to Hereditary Persistence of Fetal Haemoglobin (HPFH) and beta thalassemia ...
Varun Kumar Singh, Pavithra Prabhakar, Sushma Belurkar, Chethan Manohar   +3 more
doaj