Results 121 to 130 of about 45,973 (258)

Selective phosphodiesterase 4 inhibitor roflumilast reduces inflammation and lung injury in models of betacoronavirus infection in mice [PDF]

Inflammation Research
OBJECTIVE We aimed to understand the potential therapeutic and anti-inflammatory effects of the phosphodiesterase-4 (PDE4) inhibitor roflumilast in models of pulmonary infection caused by betacoronaviruses.
Vinícius Amorim Beltrami, Flávia Rayssa Braga Martins, Débora Gonzaga Martins, Celso Martins Queiroz‐Junior, Franciel Batista Félix, Letícia Cassiano Resende, Felipe Rocha da Silva Santos, Larisse de Souza Barbosa Lacerda, Victor Rodrigues de Melo Costa, Walison N. Silva, Pedro Pires Goulart Guimarães, Gabriela Guimarães, Frederico Marianetti Soriani, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Vanessa Pinho   +15 more
openalex   +2 more sources

Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure–Activity Relationship

Influenza and Other Respiratory Viruses, Volume 19, Issue 10, October 2025.
ABSTRACT Background Natural alkaloids are a structurally diverse class of bioactive compounds with significant therapeutic potential. This study aimed to evaluate the in vitro antiviral activity of various natural alkaloids against coronaviruses, clarify molecular effects via bioassays and docking, and explore structure–activity relationships.
Marcela Safratova, Yu‐Li Chen, Anna Hostalkova, Jakub Chlebek, Chung‐Fan Hsieh, Bing‐Hung Chen, Lucie Cahlikova, Stefan Kosturko, Anders Backlund, Jim‐Tong Horng, Tsong‐Long Hwang, Michal Korinek   +11 more
wiley   +1 more source

Betacoronavirus 1 in alpacas (Vicugna pacos) in the High Peruvian Andes

Small Ruminant Research, 2015
Genetic sequences highly related to Bovine coronavirus (BCoV) were detected in fecal samples from Peruvian 1-3 week old alpaca crias located on six farms in Puno department, some of which shared pastures with cattle. A total of 60 samples were screened for coronavirus using a nested PCR amplification of a fragment of the RNA-dependent RNA polymerase ...
L. Luna, Lenin Maturrano, Raúl Rosadio, Fernanda Dornelas Florentino Silva, Fábio Gregori, Paulo Eduardo Brandão, Rodrigo Martins Soares   +6 more
openaire   +3 more sources

Detecting and Monitoring Porcine Hemagglutinating Encephalomyelitis Virus, an Underresearched Betacoronavirus

mSphere, 2020
There is a paucity of information concerning the ecology of porcine hemagglutinating encephalomyelitis virus (PHEV) in commercial swine herds. This study provided evidence that PHEV infection is endemic and highly prevalent in U.S. swine herds. These results raised questions for future studies regarding the impact of endemic PHEV on swine health and ...
Mora-Díaz, Juan Carlos, Magtoto, Ronaldo, Houston, Elizabeth, Baum, David, Carrillo-Ávila, José Antonio, Temeeyasen, Gun, Zimmerman, Jeff, Piñeyro, Pablo, Giménez-Lirola, Luis   +8 more
openaire   +6 more sources

SARS-CoV-2: estructura, replicación y mecanismos fisiopatológicos relacionados con COVID-19

Gaceta Médica Boliviana, 2020
SARS-CoV2 es causante del síndrome respiratorio agudo severo, enfermedad que ha sido también nombrada COVID-19, fue notificado a fines del año 2019 como un nuevo betacoronavirus en personas expuestas en un mercado de mariscos en Wuhan, China.
Gabriela Antezana Llaveta, Jaime Arandia-Guzmán   +1 more
doaj   +1 more source

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Advanced Science, Volume 12, Issue 36, September 25, 2025.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
wiley   +1 more source

Hallmarks of Alpha- and Betacoronavirus non-structural protein 7+8 complexes [PDF]

Science Advances, 2020
Coronaviral nsp7+8 complexes follow species- and stoichiometry-specific assembly pathways determined by few amino acid changes.
Charlotte Uetrecht, Charlotte Uetrecht, Ramakanth Madhugiri, Boris Krichel, Ganesh Bylapudi, L. Brings, Kristina Lorenzen, Martin Koehler, Clement E. Blanchet, Renato Zenobi, C. Schmidt, John Ziebuhr, Robin Schubert, Dmitri I. Svergun   +13 more
openaire   +8 more sources

Discovery of novel alphacoronaviruses in European rodents and shrews [PDF]

, 2016
Eight hundred and thirteen European rodents and shrews encompassing seven different species were screened for alphacoronaviruses using PCR detection.
Ball, J, Behnke, J, Chapman, S, Danjittrong, T, Dayman, E, Dobbs, P, Horncastle, E, McClure, C, Onianwa, O, Strong, V, Tarlinton, R, Tsoleridis, T, Wachtl, M, Zhu, M   +13 more
core   +2 more sources

Cross-Species Transmission of Bat Coronaviruses in the Americas: Contrasting Patterns between Alphacoronavirus and Betacoronavirus

Microbiology spectrum, 2022
Coronaviruses (CoVs) have a strong zoonotic potential due to their high rates of evolvability and their capacity for overcoming host-specific barriers. Bats harbor the largest number of CoV species among mammals, with the highest CoV diversity found in ...
D. A. Caraballo
semanticscholar   +1 more source

Seasonal Coronavirus‐Induced Immunological Imprinting and Previous Herpesvirus Infections in Patients With Long COVID

Journal of Medical Virology, Volume 97, Issue 9, September 2025.
ABSTRACT Long COVID (LC) is a post‐acute infection syndrome affecting 5%–10% of individuals infected by SARS‐CoV‐2. Here, we aimed to study SARS‐CoV‐2 humoral immunity, immunological imprinting by endemic coronaviruses, and previous herpesvirus infections in LC. We included 47 LC patients and 41 controls who fully recovered from COVID‐19.
W. Ashwin Mak, Daphne Wapperom, Anne‐Lotte Redel, Johannes G. M. Koeleman, Pieter W. Smit, Wai‐Kwan Lam‐Tse, Tom van der Poll, Hung‐Jen Chen, Jeroen den Dunnen, Gert‐Jan Braunstahl, David S. Y. Ong   +10 more
wiley   +1 more source