Results 121 to 130 of about 46,357 (231)

Discovery of novel alphacoronaviruses in European rodents and shrews [PDF]

, 2016
Eight hundred and thirteen European rodents and shrews encompassing seven different species were screened for alphacoronaviruses using PCR detection.
Ball, J, Behnke, J, Chapman, S, Danjittrong, T, Dayman, E, Dobbs, P, Horncastle, E, McClure, C, Onianwa, O, Strong, V, Tarlinton, R, Tsoleridis, T, Wachtl, M, Zhu, M   +13 more
core   +2 more sources

Human Betacoronavirus OC43 Interferes with the Integrated Stress Response Pathway in Infected Cells

Viruses
Viruses evolve many strategies to ensure the efficient synthesis of their proteins. One such strategy is the inhibition of the integrated stress response—the mechanism through which infected cells arrest translation through the phosphorylation of the ...
Stacia M. Dolliver, Caleb Galbraith, Denys A. Khaperskyy   +2 more
semanticscholar   +1 more source

Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure–Activity Relationship

Influenza and Other Respiratory Viruses, Volume 19, Issue 10, October 2025.
ABSTRACT Background Natural alkaloids are a structurally diverse class of bioactive compounds with significant therapeutic potential. This study aimed to evaluate the in vitro antiviral activity of various natural alkaloids against coronaviruses, clarify molecular effects via bioassays and docking, and explore structure–activity relationships.
Marcela Safratova, Yu‐Li Chen, Anna Hostalkova, Jakub Chlebek, Chung‐Fan Hsieh, Bing‐Hung Chen, Lucie Cahlikova, Stefan Kosturko, Anders Backlund, Jim‐Tong Horng, Tsong‐Long Hwang, Michal Korinek   +11 more
wiley   +1 more source

The SARS-coronavirus-host interactome [PDF]

, 2011
Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to ...
Brunn, Albrecht von, Carbajo-Lozoya, Javier, Dall'Armi, Ekatarina von, Ditt, Vanessa, Drosten, Christian, Friedel, Caroline C., Haas, Juergen G., Herrler, Georg, Herzog, Petra, Hilgenfeld, Rolf, Kallies, Stefan, Kuri, Thomas, Kögl, Manfred, Müller, Marcel A., Niemeyer, Daniela, Pfefferle, Susanne, Pumpor, Ksenia, Pöhlmann, Stefan, Schwarz, Frank, Schwegmann-Wessels, Christel, Schöpf, Julia, Steffen, Imke, Stellberger, Thorsten, Thiel, Heinz-Jürgen, Thiel, Volker, Weber, Friedemann, Zimmer, Ralf, Züst, Roland   +27 more
core   +1 more source

PHEV infection: A promising model of betacoronavirus-associated neurological and olfactory dysfunction

PLoS Pathogens, 2022
Porcine hemagglutinating encephalomyelitis virus (PHEV) is a highly neurotropic coronavirus belonging to the genus Betacoronavirus. Similar to pathogenic coronaviruses to which humans are susceptible, such as SARS-CoV-2, PHEV is transmitted primarily ...
Junchao Shi, Zi Li, Jing Zhang, Rongyi Xu, Y. Lan, Jiyu Guan, Rui Gao, Zhenzhen Wang, Huijun Lu, Baofeng Xu, Kui Zhao, F. Gao, Wenqi He   +12 more
semanticscholar   +1 more source

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Advanced Science, Volume 12, Issue 36, September 25, 2025.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
wiley   +1 more source

New coronavirus outbreak. Lessons learned from the severe acute respiratory syndrome epidemic [PDF]

, 2016
System dynamics approach offers great potential for addressing how intervention policies can affect the spread of emerging infectious diseases in complex and highly networked systems.
Donado-Campos, J, Morillas, Francisco, Álvarez, Enrique   +2 more
core   +1 more source

Impact of COVID-19 on maxillofacial surgery practice: a worldwide survey [PDF]

, 2020
The outbreak of coronavirus disease 2019 (COVID-19) is rapidly changing our habits. To date, April 12, 2020, the virus has reached 209 nations, affecting 1.8 million people and causing more than 110,000 deaths. Maxillofacial surgery represents an example
Cascone, P, Fontanari, M, Maffia, F, Mercuri, L G, Vellone, V   +4 more
core   +1 more source

Seasonal Coronavirus‐Induced Immunological Imprinting and Previous Herpesvirus Infections in Patients With Long COVID

Journal of Medical Virology, Volume 97, Issue 9, September 2025.
ABSTRACT Long COVID (LC) is a post‐acute infection syndrome affecting 5%–10% of individuals infected by SARS‐CoV‐2. Here, we aimed to study SARS‐CoV‐2 humoral immunity, immunological imprinting by endemic coronaviruses, and previous herpesvirus infections in LC. We included 47 LC patients and 41 controls who fully recovered from COVID‐19.
W. Ashwin Mak, Daphne Wapperom, Anne‐Lotte Redel, Johannes G. M. Koeleman, Pieter W. Smit, Wai‐Kwan Lam‐Tse, Tom van der Poll, Hung‐Jen Chen, Jeroen den Dunnen, Gert‐Jan Braunstahl, David S. Y. Ong   +10 more
wiley   +1 more source

Inhibition of Human Respiratory Influenza A Virus and Human Betacoronavirus-1 by the Blend of Double-Standardized Extracts of Aronia melanocarpa (Michx.) Elliot and Sambucus nigra L.

Pharmaceuticals, 2022
Viral and bacterial diseases are among the greatest concerns of humankind since ancient times. Despite tremendous pharmacological progress, there is still a need to search for new drugs that could treat or support the healing processes.
Michał Ochnik, Dominika Franz, Maciej Sobczyński, Piotr Naporowski, M. Banach, B. Orzechowska, M. Sochocka   +6 more
semanticscholar   +1 more source