Results 31 to 40 of about 45,973 (258)

Conserved host-pathogen interactions identify novel treatment options in betacoronavirus infections [PDF]

Signal Transduction and Targeted Therapy, 2021
Hypoxia is an underlying pathophysiological condition of a variety of devastating diseases, including acute ischemic stroke (AIS). We are faced with limited therapeutic options for AIS patients, and even after successful restoration of cerebral blood flow, the poststroke mortality is still high.
Soeren Lukassen, Roland Eils
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Inhibition of Human Respiratory Influenza A Virus and Human Betacoronavirus-1 by the Blend of Double-Standardized Extracts of Aronia melanocarpa (Michx.) Elliot and Sambucus nigra L. [PDF]

Pharmaceuticals, 2022
Viral and bacterial diseases are among the greatest concerns of humankind since ancient times. Despite tremendous pharmacological progress, there is still a need to search for new drugs that could treat or support the healing processes.
Michał Ochnik, Dominika Franz, Maciej Sobczyński, Piotr Naporowski, Mariusz Banach, Beata Orzechowska, Marta Sochocka   +6 more
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Pre-pandemic artificial MERS analog of polyfunctional SARS-CoV-2 S1/S2 furin cleavage site domain is unique among spike proteins of genus Betacoronavirus. [PDF]

BMC Genom Data
Objectives SARS-CoV-2 spike (S) glycoprotein furin cleavage site is a key determinant of SARS-CoV-2 virulence and COVID-19 pathogencity. Located at the S1/S2 junction, it is unique among sarbecoviruses but frequently found among betacoronaviruses. Recent
Lisewski AM.
europepmc   +2 more sources

Sars-Cov-2 And Betacoronavirus: What Have We Learned In 8 Months? [PDF]

Postępy Mikrobiologii - Advancements of Microbiology, 2020
Abstract In 2019, a new human pandemic coronavirus (SARS-CoV-2) emerged in Wuhan, China. We present the knowledge about SARS-CoV-2 compared to SARS-CoV and MERS-CoV. The SARS-CoV-2 is similar to other coronaviruses, nevertheless, differences were observed. Cell entry of SARS-CoV-2 is facilitated by cleavage of spike protein by furin. The
Agnieszka Kwiatek, Monika Adamczyk-Popławska   +1 more
openalex   +5 more sources

Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals

Journal of Proteome Research, 2023
Host kinases play essential roles in the host cell cycle, innate immune signaling, the stress response to viral infection, and inflammation. Previous work has demonstrated that coronaviruses specifically target kinase cascades to subvert host cell ...
Ethan J. Fritch, Angie L. Mordant, Thomas S.K. Gilbert, Carrow I. Wells, Xuan Yang, Natalie K. Barker, Emily A. Madden, Kenneth H. Dinnon, Yixuan J. Hou, Longping V. Tse, Izabella N. Castillo, Amy Sims, Nathaniel J. Moorman, Lakshmanane Premkumar, Timothy M. Willson, Laura E. Herring, Lee M. Graves, Ralph S. Baric   +17 more
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Identification of the Receptor-Binding Domain of the Spike Glycoprotein of Human Betacoronavirus HKU1 [PDF]

Journal of Virology, 2015
ABSTRACT Coronavirus spike (S) glycoproteins mediate receptor binding, membrane fusion, and virus entry and determine host range. Murine betacoronavirus (β-CoV) in group A uses the N-terminal domain (NTD) of S protein to bind to its receptor, whereas the β-CoVs severe acute respiratory syndrome CoV in group B and Middle East respiratory ...
Zhaohui Qian, Xiuyuan Ou, Luiz Gustavo Bentim Góes, Christina Osborne, Anna Castano, Kathryn V. Holmes, Samuel R. Dominguez   +6 more
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Study of the Antiviral Activity of Adamantane-Containing Chemical Compounds

Антибиотики и Химиотерапия, 2022
Influenza and coronavirus infections are especially dangerous due to being capable of causing pandemics and clinical complications in the nervous and cardiovascular systems, as well as exacerbation of chronic diseases (diabetes mellitus, heart failure ...
I. I. LYUBIMOV, E. I. ISAEVA, E. N. VETROVA, A. V. LAVROVA, N. M. GRETSKAYA, I. V. SERKOV, V. V. BEZUGLOV, G. A. GALEGOV   +7 more
doaj   +1 more source

Seasonality of Common Human Coronaviruses, United States, 2014–2021

Emerging Infectious Diseases, 2022
The 4 common types of human coronaviruses (HCoVs)—2 alpha (HCoV-NL63 and HCoV-229E) and 2 beta (HCoV-HKU1 and HCoV-OC43)—generally cause mild upper respiratory illness.
Melisa M. Shah, Amber Winn, Rebecca M. Dahl, Krista L. Kniss, Benjamin J. Silk, Marie E. Killerby   +5 more
doaj   +1 more source

Antiviral Activity of Graphene Oxide–Silver Nanocomposites Against Murine Betacoronavirus

International Journal of Nanomedicine
Background The high infectivity of coronaviruses has led to increased interest in developing new strategies to prevent virus spread. Silver nanoparticles (AgNPs) and graphene oxide (GO) have attracted much attention in the antiviral field.
Joanna Cymerys, Michalina Bartak, Anna Słońska, Agata Lange, Sławomir Jaworski, Marcin Chodkowski, Agnieszka Ostrowska, Mateusz Wierzbicki, Ewa Sawosz, Marcin W. Bańbura   +9 more
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Quasineutral multistability in an epidemiological-like model for defective-helper betacoronavirus infection in cell cultures [PDF]

Applied Mathematical Modelling
Juan C. Muñoz-Sánchez, J. Tomás Lázaro, Julia Hillung, María J. Olmo-Uceda, Josep Sardanyés, Santiago F. Elena   +5 more
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