Results 41 to 50 of about 45,973 (258)

COVID-19: perspectivas terapéuticas en IL-17/Th17

Iatreia, 2021
Las células T helper-17 (Th17) y la interleuquina (IL) IL-17 desempeñan funciones biológicas relacionadas con la protección contra infecciones por bacterias extracelulares y hongos.
Franky Úsuga-Úsuga, Luis F. García, Margarita María Velásquez-Lopera   +2 more
doaj   +1 more source

COVID-19: a perspective focus on IL-17/Th17

Iatreia, 2022
Interleukin 17 (IL-17)-producing helper T cells (Th17) and IL-17 play an important role in the defense against extracellular bacteria and fungi; however, persistent secretion of IL-17 is also an important component in the pathogenesis of many ...
Úsuga-Úsuga, Franky , García, Luis F., Velásquez-Lopera, Margarita   +2 more
doaj   +1 more source

Multiple Early Introductions of SARS-CoV-2 to Cape Town, South Africa

Viruses, 2021
Cape Town was the first city in South Africa to experience the full impact of the coronavirus disease 2019 (COVID-19) pandemic. We acquired samples from all suspected cases and their contacts during the first month of the pandemic from Tygerberg Hospital.
Susan Engelbrecht, Kayla Delaney, Bronwyn Kleinhans, Eduan Wilkinson, Houriiyah Tegally, Tania Stander, Gert van Zyl, Wolfgang Preiser, Tulio de Oliveira   +8 more
doaj   +1 more source

E3 Ubiquitin Ligase Smurf1 Regulates the Inflammatory Response in Macrophages and Attenuates Hepatic Damage during Betacoronavirus Infection. [PDF]

Pathogens
The E3 ubiquitin ligase Smurf1 catalyzes the ubiquitination and proteasomal degradation of several protein substrates related to inflammatory responses and antiviral signaling. This study investigated the role of Smurf1 in modulating inflammation induced
Souza-Costa LP, Santos FRS, Pimenta JC, Queiroz-Junior CM, Tana FL, Teixeira DC, Couto MGG, Oliveira NFM, Pereira RD, Beltrami VA, Costa PAC, Lacerda LSB, Andrade-Chaves JT, Guimarães PPG, Aguiar RS, Teixeira MM, Costa VV, Franco LH.   +17 more
europepmc   +2 more sources

Development of a Biosensor Based on Angiotensin‐Converting Enzyme II for Severe Acute Respiratory Syndrome Coronavirus 2 Detection in Human Saliva

Frontiers in Sensors, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the novel coronavirus responsible for COVID-19. Infection in humans requires angiotensin-converting enzyme II (hACE2) as the point of entry for SARS-CoV-2.
Geisianny Moreira, Geisianny Moreira, Lisseth Casso-Hartmann, Shoumen Palit Austin Datta, Shoumen Palit Austin Datta, Delphine Dean, Delphine Dean, Eric McLamore, Eric McLamore, Eric McLamore, Diana Vanegas, Diana Vanegas   +11 more
doaj   +1 more source

Novel Betacoronavirus in Dromedaries of the Middle East, 2013 [PDF]

Emerging Infectious Diseases, 2014
In 2013, a novel betacoronavirus was identified in fecal samples from dromedaries in Dubai, United Arab Emirates. Antibodies against the recombinant nucleocapsid protein of the virus, which we named dromedary camel coronavirus (DcCoV) UAE-HKU23, were detected in 52% of 59 dromedary serum samples tested.
Mareena, R, Yuen, KY, Fan, YY, Cai, J, Sivakumar, S, Lau, CY, Tsang, KL, Johnson, B, Woo, PCY, Wong, YM, Lau, SKP, Wernery, U, Yip, CY, Chan, KH   +13 more
openaire   +5 more sources

The Pro-Inflammatory Chemokines CXCL9, CXCL10 and CXCL11 Are Upregulated Following SARS-CoV-2 Infection in an AKT-Dependent Manner

Viruses, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible RNA virus that is the causative agent of the Coronavirus disease 2019 (COVID-19) pandemic.
Victoria Callahan, Seth Hawks, Matthew A. Crawford, Caitlin W. Lehman, Holly A. Morrison, Hannah M. Ivester, Ivan Akhrymuk, Niloufar Boghdeh, Rafaela Flor, Carla V. Finkielstein, Irving Coy Allen, James Weger-Lucarelli, Nisha Duggal, Molly A. Hughes, Kylene Kehn-Hall   +14 more
doaj   +1 more source

CoV-RBD121-NP Vaccine Candidate Protects against Symptomatic Disease following SARS-CoV-2 Challenge in K18-hACE2 Mice and Induces Protective Responses That Prevent COVID-19-Associated Immunopathology

Vaccines, 2021
We developed a SARS-CoV-2 vaccine candidate (CoV-RBD121-NP) comprised of a tobacco mosaic virus-like nanoparticle conjugated to the receptor-binding domain of the spike glycoprotein of SARS-CoV-2 fused to a human IgG1 Fc domain.
Jennifer K. DeMarco, Joshua M. Royal, William E. Severson, Jon D. Gabbard, Steve Hume, Josh Morton, Kelsi Swope, Carrie A. Simpson, John W. Shepherd, Barry Bratcher, Kenneth E. Palmer, Gregory P. Pogue   +11 more
doaj   +1 more source

MERS–Related Betacoronavirus inVespertilio superansBats, China [PDF]

Emerging Infectious Diseases, 2014
(Uploaded by Plazi for the Bat Literature Project) No abstract provided.
Yang, Li, Wu, Zhiqiang, Ren, Xianwen, Yang, Fan, Zhang, Junpeng, He, Guimei, Dong, Jie, Sun, Lilian, Zhu, Yafang, Zhang, Shuyi, Jin, Qi   +10 more
openaire   +5 more sources

Structural mapping of antibody landscapes to human betacoronavirus spike proteins [PDF]

Science Advances, 2021
AbstractPreexisting immunity against seasonal coronaviruses (CoV) represents an important variable in predicting antibody responses and disease severity to Severe Acute Respiratory Syndrome CoV-2 (SARS-2) infections. We used electron microscopy based polyclonal epitope mapping (EMPEM) to characterize the antibody specificities against β-CoV spike ...
Zhan X, Aleksandar Antanasijevic, Nurgun Kose, Torrents de la Pena A, Naveenchandra Suryadevara, Jonathan L. Torres, Andrew B. Ward, James E. Crowe, James E. Crowe, Abigail M. Jackson, Sandhya Bangaru, Jeffrey Copps, L.M. Sewall   +12 more
openaire   +3 more sources