Results 151 to 160 of about 770 (178)

Elevated circulating levels of betatrophin are associated with polycystic ovary syndrome

Endocrine, 2016
Betatrophin is a newly identified hormone determined to be a potent inducer of pancreatic beta cell proliferation in response to insulin resistance in mice.
Mehmet Calan, Özgur Yilmaz, Tuncay Kume   +2 more
exaly   +2 more sources

Moderate-intensity exercise decreases the circulating level of betatrophin and its correlation among markers of obesity in women [PDF]

Journal of Basic and Clinical Physiology and Pharmacology, 2022
Objectives Positive energy homeostasis due to overnutrition and a sedentary lifestyle triggers obesity. Obesity has a close relationship with elevated levels of betatrophin and may increase the risk of developing metabolic syndrome.
Purwo Sri Rejeki, Lilik Herawati, Adi Pranoto   +2 more
exaly   +2 more sources

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Betatrophin in Diabetes Mellitus: the Epidemiological Evidence in Humans

Current Diabetes Reports, 2015
The prevalence of type 2 diabetes is increasing worldwide, and while numerous treatments exist, none of the current pharmacologic therapies is curative. Pharmacologic approaches that increase beta cell mass may present an avenue for actual cure. There have been numerous reports on factors that can induce beta cell proliferation in rodents, whereas ...
Daniel, Espes, Mats, Martinell, Hanna, Liljebäck, Per-Ola, Carlsson   +3 more
openaire   +2 more sources

Evaluation of circulating betatrophin levels in gestational diabetes mellitus

Gynecological Endocrinology, 2015
Experimental data indicate that betatrophin plays a significant role in the regulation of lipid metabolism and glucose homeostasis. In recent years, considerable attention has focused on the relationship between betatrophin and diabetes mellitus in humans.
Onur Erol, Aysel Uysal Derbent
exaly   +3 more sources

ANGPTL8 (betatrophin) role in diabetes and metabolic diseases

Diabetes/Metabolism Research and Reviews, 2017
SummaryDiabetes is a major disease worldwide that is reaching epidemic levels. Its increased prevalence as well as its association with a high number of complications such as cardiovascular diseases, nephropathy, and retinopathy makes it an important disease for investigation.
Mohamed Abu‐Farha, Jehad Abubaker, Jaakko Tuomilehto   +2 more
openaire   +2 more sources

Metabolomics Shows an Association of Betatrophin with Bile Acids, Suggesting an Involvement of Betatrophin in Bile Acid–Mediated Metabolic Control

Diabetes, 2018
Betatrophin, also known as ANGPTL8, is secreted by liver and adipose tissue and plays an important role in glucose and lipid metabolism, but the mechanisms behind this remain unclear. Betatrophin is highly activated by active triiodothyronine (T3), a key player in metabolic control, which in turn is activated by bile acids (BA) via the BA-G-protein ...
ANDREAS LEIHERER, AXEL MUENDLEIN, KATHRIN GEIGER, CHRISTOPH H. SAELY, EVA-MARIA BRANDTNER, JANINE EBNER, BARBARA LARCHER, ARTHUR MADER, PETER FRAUNBERGER, HEINZ DREXEL   +9 more
openaire   +1 more source

Abstract 18157: Impact of Betatrophin (ANGPTL8) R59W Mutation for Future Diabetes, and Minimal Modification of Circulating Betatrophin With Strong Statins

Circulation, 2015
Betatrophin (ANGPTL8), also known as “Lipasin” (lipoprotein lipase inhibitor), has been reported as a dual-regulator of glucose and lipid metabolism. Functional variant R59W in betatrophin gene is common in Japanese (minor allele 25%) compared with Caucasian (5%). Little is known about long-term impact of this gene variant, and also about the effect of
Atsushi Nohara, Masa-aki Kawashiri, Hiroaki Hattori, Tadao Iwasaki, Jianhui Liu, Kunimasa Yagi, Mie Yoshida, Mika Mori, Chiaki Nakanishi, Hayato Tada, Akihiro Inazu, Takeshi Kobayashi, Masakazu Yamagishi, Hiroshi Mabuchi   +13 more
openaire   +1 more source

Assessment of circulating betatrophin levels in intrahepatic cholestasis of pregnancy

The Journal of Maternal-Fetal & Neonatal Medicine, 2018
Objective: To investigate maternal serum levels of betatrophin and their relationship with total bile acid (TBA) levels in patients with intrahepatic cholestasis of pregnancy (ICP).Materials and methods: Fifty-nine pregnant women with ICP (31 patients with severe and 28 patients with mild disease classifications) and 23 healthy women with uncomplicated
Özgür, Kara, Ayşe, Kirbas, Kadriye, Yakut, Korkut, Daglar, Hakan, Timur, Zeynep, Ozturk İnal, Yaprak, Engin-Ustun   +6 more
openaire   +2 more sources

Evaluation of Betatrophin, Chemerin, and Kisspeptin Levels in Acromegaly Patients

Endocrine, Metabolic & Immune Disorders - Drug Targets
Background: Acromegaly is a chronic disorder characterized by excessive growth hormone (GH) secretion from pituitary somatotroph cells, resulting in metabolic complications and increased morbidity. Elevated levels of GH and insulin-like growth factor 1 (IGF-1) contribute to various metabolic and morphological abnormalities.
Dondu Aysegul, Cayan, Senay, Topsakal, Esin, Avci   +2 more
openaire   +2 more sources

Betatrophin in nonalcoholic fatty liver disease

European Journal of Gastroenterology & Hepatology, 2016
Hasan, Gurel, Teoman, Dogru
openaire   +2 more sources