Results 151 to 160 of about 814 (180)
Evaluation of circulating betatrophin levels in gestational diabetes mellitus
Gynecological Endocrinology, 2015 Experimental data indicate that betatrophin plays a significant role in the regulation of lipid metabolism and glucose homeostasis. In recent years, considerable attention has focused on the relationship between betatrophin and diabetes mellitus in humans.
Onur Erol, Hamît Yasar Ellidağ
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Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes [PDF]
Diabetologia, 2013 Aims/hypothesis The hormone betatrophin was recently described as a potent stimulator of beta cell proliferation in mice. Insulin resistance, but not insulin deficiency, caused upregulation of betatrophin expression.
Daniel Espes +2 more
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An explanation for recent discrepancies in levels of human circulating betatrophin
Diabetologia, 2014To the Editor: In addition to hyperglycaemia and hyperinsulinaemia, type 2 diabetes mellitus is often associated with hypertriglyceridaemia. Recently, we and others have identified a novel circulating factor, referred to as lipasin [1], refeeding induced in fat and liver (RIFL) [2], angiopoietin-like protein 8 (ANGPTL8) [3, 4], and betatrophin [5 ...
Abdul Abou-Samra +2 more
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Hormone and Metabolic Research, 2017 Many inconsistent findings are reported on the correlation between circulating betatrophin and insulin resistance in the different population. The aim of this analysis was to explore the correlation between the level of betatrophin and insulin resistance
Guangda Xiang, Jinling Xu
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Betatrophin in Diabetes Mellitus: the Epidemiological Evidence in Humans
Current Diabetes Reports, 2015The prevalence of type 2 diabetes is increasing worldwide, and while numerous treatments exist, none of the current pharmacologic therapies is curative. Pharmacologic approaches that increase beta cell mass may present an avenue for actual cure. There have been numerous reports on factors that can induce beta cell proliferation in rodents, whereas ...
Daniel, Espes +3 more
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ANGPTL8 (betatrophin) role in diabetes and metabolic diseases
Diabetes/Metabolism Research and Reviews, 2017SummaryDiabetes is a major disease worldwide that is reaching epidemic levels. Its increased prevalence as well as its association with a high number of complications such as cardiovascular diseases, nephropathy, and retinopathy makes it an important disease for investigation.
Mohamed Abu‐Farha +2 more
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Diabetes, 2018
Betatrophin, also known as ANGPTL8, is secreted by liver and adipose tissue and plays an important role in glucose and lipid metabolism, but the mechanisms behind this remain unclear. Betatrophin is highly activated by active triiodothyronine (T3), a key player in metabolic control, which in turn is activated by bile acids (BA) via the BA-G-protein ...
ANDREAS LEIHERER +9 more
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Betatrophin, also known as ANGPTL8, is secreted by liver and adipose tissue and plays an important role in glucose and lipid metabolism, but the mechanisms behind this remain unclear. Betatrophin is highly activated by active triiodothyronine (T3), a key player in metabolic control, which in turn is activated by bile acids (BA) via the BA-G-protein ...
ANDREAS LEIHERER +9 more
openaire +1 more source
Circulation, 2015
Betatrophin (ANGPTL8), also known as “Lipasin” (lipoprotein lipase inhibitor), has been reported as a dual-regulator of glucose and lipid metabolism. Functional variant R59W in betatrophin gene is common in Japanese (minor allele 25%) compared with Caucasian (5%). Little is known about long-term impact of this gene variant, and also about the effect of
Atsushi Nohara +13 more
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Betatrophin (ANGPTL8), also known as “Lipasin” (lipoprotein lipase inhibitor), has been reported as a dual-regulator of glucose and lipid metabolism. Functional variant R59W in betatrophin gene is common in Japanese (minor allele 25%) compared with Caucasian (5%). Little is known about long-term impact of this gene variant, and also about the effect of
Atsushi Nohara +13 more
openaire +1 more source
Assessment of circulating betatrophin levels in intrahepatic cholestasis of pregnancy
The Journal of Maternal-Fetal & Neonatal Medicine, 2018Objective: To investigate maternal serum levels of betatrophin and their relationship with total bile acid (TBA) levels in patients with intrahepatic cholestasis of pregnancy (ICP).Materials and methods: Fifty-nine pregnant women with ICP (31 patients with severe and 28 patients with mild disease classifications) and 23 healthy women with uncomplicated
Özgür, Kara +6 more
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Betatrophin in nonalcoholic fatty liver disease
European Journal of Gastroenterology & Hepatology, 2016Hasan, Gurel, Teoman, Dogru
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