Beti Bachao Beti Padhao Scheme, Haryana: Improvement in sex ratio at birth and other achievements
Indian Journal of Community and Family Medicine, 2021 In world, almost half of the total population made up of women but they still lag behind men in a lot of areas. The skewed child sex ratio is a prime indicator of women disempowerment, lack of value attached to her and disrespect. Over few years, a significant fraction of number of women has been at the receiving end of discrimination and exploitation.
Yogender Malik
doaj +6 more sources
Combining BET inhibition with SMAC mimetics restricts tumor growth and triggers immune surveillance in preclinical cancer models [PDF]
Cell Reports MedicineSummary: Second mitochondrial activator of caspase (SMAC) mimetics (SMACm) and bromodomain and extra-terminal domain (BET) inhibitors (BETi) are two distinct classes of novel anticancer therapeutics.
Ksenija Slavic Obradovic +24 more
doaj +2 more sources
BET inhibitors reduce tumor growth in preclinical models of gastrointestinal gene signature–positive castration-resistant prostate cancer [PDF]
The Journal of Clinical InvestigationA subgroup (~20%–30%) of castration-resistant prostate cancer (CRPC) aberrantly expresses a gastrointestinal (GI) transcriptome governed by 2 GI-lineage-restricted transcription factors, HNF1A and HNF4G.
Shipra Shukla +20 more
doaj +2 more sources
BET inhibition revealed varying MYC dependency mechanisms independent of gene alterations in aggressive B-cell lymphomas [PDF]
Clinical EpigeneticsBackground MYC-driven lymphomas are a subset of B-cell lymphomas characterized by genetic alterations that dysregulate the expression of the MYC oncogene.
Loris Delrieu +11 more
doaj +2 more sources
Profiling triple-negative breast cancer-specific super-enhancers identifies high-risk mesenchymal development subtype and BETi-Targetable vulnerabilities [PDF]
Molecular CancerBackground Super-enhancers (SEs) are critical regulators of tumorigenesis and represent promising targets for bromodomain and extra-terminal domain inhibitors (BETi). However, clinical studies across various solid tumors, including triple-negative breast
Qing-shan Chen +10 more
doaj +2 more sources
Bromodomain and extra-terminal protein inhibitors modulate natural killer cell function and differentiation [PDF]
Scientific ReportsNatural killer (NK) cells are integral to the innate immune system, playing a crucial role in immune surveillance and the rapid response to virally infected and tumor cells.
Eric S. Geanes +9 more
doaj +2 more sources
BRD4 Inhibitor Alleviates Recurrent Spontaneous Abortion via Regulating BRD4/STAT3/IL‐17A Axis to Decrease the Th17 Cell Differentiation [PDF]
Reproductive Medicine and BiologyPurpose Recurrent spontaneous abortion (RSA) is an abnormal phenomenon that severely affects women's quality of life. Inhibiting Th17 cell differentiation can alleviate RSA.
Fen Liu, Zhenhui Zhang, Chengying Yang
doaj +2 more sources
Immune modulation in solid tumors: a phase 1b study of RO6870810 (BET inhibitor) and atezolizumab (PD-L1 inhibitor) [PDF]
BMC CancerPurpose Bromodomain and extra-terminal domain (BET) inhibitors (BETi) have demonstrated epigenetic modulation capabilities, specifically in transcriptional repression of oncogenic pathways.
Daniel Marbach +20 more
doaj +2 more sources
Biomedicines, 2021 BET inhibitors (BETi) including OTX015 (MK-8628) and JQ1 demonstrated antileukemic activity including NPM1c AML cells. Nevertheless, the biological consequences of BETi in NPM1c AML were not fully investigated.
Hanane Djamai +18 more
doaj +1 more source
Bir Aşk Söyleminden Parçalar Işığında Türk Hikayelerine Kısa Bir Bakış
Mukaddime, 2023 Çalışmamız Roland Barthes’in “Bir Aşk Söyleminden Parçalar” adlı metni temelinde Türk hikayelerinin kısa bir değerlendirmesidir. Barthes’in rastlantısal ve düzenli okumalar tekniği kullanılarak yapılan incelemede toplam yirmi yedi başlık tespit edilmiş ...
Serdal Kara
doaj +1 more source