Results 1 to 10 of about 29,488 (242)

Economic evaluation of betibeglogene autotemcel (Beti-cel) gene addition therapy in transfusion-dependent β-thalassemia [PDF]

Journal of Market Access & Health Policy, 2021
Background Standard of care (SoC) for transfusion-dependent β-thalassemia (TDT) requires lifelong, regular blood transfusions as well as chelation to reduce iron accumulation.
Anuraag R. Kansal, Odette S. Reifsnider, Sarah B. Brand, Neil Hawkins, Anna Coughlan, Shujun Li, Lael Cragin, Clark Paramore, Andrew C. Dietz, J. Jaime Caro   +9 more
doaj   +2 more sources

Combining BET inhibition with SMAC mimetics restricts tumor growth and triggers immune surveillance in preclinical cancer models [PDF]

Cell Reports Medicine
Summary: Second mitochondrial activator of caspase (SMAC) mimetics (SMACm) and bromodomain and extra-terminal domain (BET) inhibitors (BETi) are two distinct classes of novel anticancer therapeutics.
Ksenija Slavic Obradovic, Florian Ebner, Artem V. Artemov, Martina Miotto, Paula-Elena Traexler, Robin Jacob, Ha Pham Thi Thanh, Regina Ruzicka, Andreas Wernitznig, Ines Baumann, Daniel Gerlach, Maria-Antonietta Impagnatiello, Salvatore Siena, Mary Murphy, Reniqua House, Ulrich Reiser, Valeria Santoro, Johannes Popow, Sebastian Carotta, Anke Baum, Jesse Lipp, Alberto Bardelli, Ulrike Tontsch-Grunt, Mariangela Russo, Martin Aichinger   +24 more
doaj   +2 more sources

BET inhibitors reduce tumor growth in preclinical models of gastrointestinal gene signature–positive castration-resistant prostate cancer [PDF]

The Journal of Clinical Investigation
A subgroup (~20%–30%) of castration-resistant prostate cancer (CRPC) aberrantly expresses a gastrointestinal (GI) transcriptome governed by 2 GI-lineage-restricted transcription factors, HNF1A and HNF4G.
Shipra Shukla, Dan Li, Woo Hyun Cho, Dana M. Schoeps, Holly M. Nguyen, Jennifer L. Conner, Marjorie L. Roskes, Anisha Tehim, Gabriella Bayshtok, Mohini R. Pachai, Juan Yan, Nicholas A. Teri, Eric Campeau, Sarah Attwell, Patrick Trojer, Irina Ostrovnaya, Anuradha Gopalan, Ekta Khurana, Eva Corey, Ping Chi, Yu Chen   +20 more
doaj   +2 more sources

BET inhibition revealed varying MYC dependency mechanisms independent of gene alterations in aggressive B-cell lymphomas [PDF]

Clinical Epigenetics
Background MYC-driven lymphomas are a subset of B-cell lymphomas characterized by genetic alterations that dysregulate the expression of the MYC oncogene.
Loris Delrieu, Sieme Hamaidia, Emilie Montaut, Andrea Cecilia Garcia-Sandoval, Camille Teste, Patricia Betton-Fraisse, Thierry Bonnefoix, Sylvain Carras, Rémy Gressin, Christine Lefebvre, Jérôme Govin, Anouk Emadali   +11 more
doaj   +2 more sources

Profiling triple-negative breast cancer-specific super-enhancers identifies high-risk mesenchymal development subtype and BETi-Targetable vulnerabilities [PDF]

Molecular Cancer
Background Super-enhancers (SEs) are critical regulators of tumorigenesis and represent promising targets for bromodomain and extra-terminal domain inhibitors (BETi). However, clinical studies across various solid tumors, including triple-negative breast
Qing-shan Chen, Rui-zhao Cai, Yan Wang, Ge-hao Liang, Kai-ming Zhang, Xiao-Yu Yang, Dong Yang, De-Chang Zhao, Xiao-Feng Zhu, Rong Deng, Jun Tang   +10 more
doaj   +2 more sources

Bromodomain and extra-terminal protein inhibitors modulate natural killer cell function and differentiation [PDF]

Scientific Reports
Natural killer (NK) cells are integral to the innate immune system, playing a crucial role in immune surveillance and the rapid response to virally infected and tumor cells.
Eric S. Geanes, Gage Greening, Maria Aggelakopoulou, Linh Huyen Truong, Santosh Khanal, Cas LeMaster, Marc Herman, Rebecca McLennan, Persephone Borrow, Todd Bradley   +9 more
doaj   +2 more sources

Le discours paremiologique beti dans Le sorcier signe et persiste de Camille Nkoa Atenga  [PDF]

Multilinguales, 2019
In the last few decades, there has been a renewal of aesthetics in the French African literature in general and Cameroon in particular. Indeed, the contact with the otherness of the west has influenced the ways of doing, dressing, thinking, and being ...
Mouhamadou Ngapout Kpoumié
doaj   +2 more sources

BRD4 Inhibitor Alleviates Recurrent Spontaneous Abortion via Regulating BRD4/STAT3/IL‐17A Axis to Decrease the Th17 Cell Differentiation [PDF]

Reproductive Medicine and Biology
Purpose Recurrent spontaneous abortion (RSA) is an abnormal phenomenon that severely affects women's quality of life. Inhibiting Th17 cell differentiation can alleviate RSA.
Fen Liu, Zhenhui Zhang, Chengying Yang
doaj   +2 more sources

Immune modulation in solid tumors: a phase 1b study of RO6870810 (BET inhibitor) and atezolizumab (PD-L1 inhibitor) [PDF]

BMC Cancer
Purpose Bromodomain and extra-terminal domain (BET) inhibitors (BETi) have demonstrated epigenetic modulation capabilities, specifically in transcriptional repression of oncogenic pathways.
Daniel Marbach, Jurriaan Brouer-Visser, Laura Brennan, Sabine Wilson, Iakov I. Davydov, Nicolas Staedler, José Duarte, Iris Martinez Quetglas, Eveline Nüesch, Marta Cañamero, Evelyne Chesné, George Au-Yeung, Erika Hamilton, Stephanie Lheureux, Debra L. Richardson, Iben Spanggaard, Bruno Gomes, Izolda Franjkovic, Mark DeMario, Martin Kornacker, Katharina Lechner   +20 more
doaj   +2 more sources

Reinterpreting “Beti Bachao, Beti Padhao”: The ‘Educated’ Daughter and Intergenerational Reparation in Manjula Padmanabhan’s Escape and The Island of Lost Girls

The Grove
This article analyses Manjula Padmanabhan’s  Escape and The Island of Lost Girls to explore the equation between daughterhood  and education, with a special focus on the entanglement of the parental figures in such an equation.
Syeda Shehnaz, Dr. Oindri Roy
doaj   +3 more sources