Results 41 to 50 of about 7,885 (162)

BET inhibition revealed varying MYC dependency mechanisms independent of gene alterations in aggressive B-cell lymphomas

Clinical Epigenetics
Background MYC-driven lymphomas are a subset of B-cell lymphomas characterized by genetic alterations that dysregulate the expression of the MYC oncogene.
Loris Delrieu, Sieme Hamaidia, Emilie Montaut, Andrea Cecilia Garcia-Sandoval, Camille Teste, Patricia Betton-Fraisse, Thierry Bonnefoix, Sylvain Carras, Rémy Gressin, Christine Lefebvre, Jérôme Govin, Anouk Emadali   +11 more
doaj   +1 more source

Breathing in Plants and Chaos—Cosmic Tree Events in Cameroon and Beyond

Anthropology of Consciousness, EarlyView.
ABSTRACT Contemporary practices of tapping into the wisdom of ancestral trees are described through three entangled recent events lived within the context of Bantu practices in Cameroon. In the three instances, the steered or chance encounters with high potency trees were serendipitous telling moments which brought something new to the horizon.
Julie Laplante, Armel Lekeufack, Nina Tamara Barbosa Ponce, Roger Amos Kañaa   +3 more
wiley   +1 more source

Integrating novel therapeutic strategies in myeloproliferative neoplasms: Driving disease‐directed progress

British Journal of Haematology, EarlyView.
Summary Over the past decade, there has been a substantial increase in the diversity and number of therapeutic options for myeloproliferative neoplasms (MPNs). While many remain within the clinical trial arena, the clinician and patient community have seen more approvals reaching the clinic and a rethink on how best we should be approaching these ...
Trung Q. Ngo, Maria Georgiou, Donal P. McLornan, Claire N. Harrison   +3 more
wiley   +1 more source

Using Long‐Term Monitoring Data to Assess Temporal Patterns in Fish Community Assemblages in Florida Lakes

Fisheries Management and Ecology, Volume 33, Issue 5, Page 1044-1056, October 2026.
ABSTRACT In an effort to increase the relevancy of fish community data for management, we used fish community data to conduct a statewide assessment of Florida's freshwater fisheries resources and compare the relationships between environmental factors and freshwater fish communities over time.
Kimberly I. Bonvechio, Andrea Sylvia, Andrew K. Carlson   +2 more
wiley   +1 more source

BET Bromodomain Inhibitors Which Permit Treg Function Enable a Combinatorial Strategy to Suppress GVHD in Pre-clinical Allogeneic HSCT

Frontiers in Immunology, 2019
A recent approach for limiting production of pro-inflammatory cytokines has been to target bromodomain and extra-terminal (BET) proteins. These epigenetic readers of histone acetylation regulate transcription of genes involved in inflammation ...
Sabrina N. Copsel, Sabrina N. Copsel, Casey O. Lightbourn, Henry Barreras, Ines Lohse, Ines Lohse, Dietlinde Wolf, Cameron S. Bader, John Manov, Brandon J. Kale, Devangi Shah, Shaun P. Brothers, Shaun P. Brothers, Victor L. Perez, Krishna V. Komanduri, Krishna V. Komanduri, Krishna V. Komanduri, Claes Wahlestedt, Claes Wahlestedt, Robert B. Levy, Robert B. Levy, Robert B. Levy, Robert B. Levy   +22 more
doaj   +1 more source

Identification of a Novel Small Molecule Facilitating HIV Elimination by the “Shock‐And‐Kill” Approach

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Antiretroviral therapy (ART) has markedly improved the prognosis of people living with HIV (PLWH); however, latent viral reservoirs remain a major barrier to a cure. The “Shock and Kill” strategy aims to reactivate latent provirus with latency‐reversing agents (LRAs) and subsequently eliminate the infected cells, yet most LRAs characterized to
Yuichiro Hara, Haruki Kitamura, Kouki Matsuda, Chieko Fujisaki, Sayaka Sukegawa, Kosuke Tanimoto, Kenji Maeda, Hiroaki Takeuchi   +7 more
wiley   +1 more source

Preclinical Studies Support Combined Inhibition of BET Family Proteins and Histone Deacetylases as Epigenetic Therapy for Cutaneous T-Cell Lymphoma

Neoplasia: An International Journal for Oncology Research, 2019
Advanced-stage cutaneous T-cell lymphoma (CTCL) is usually a fatal malignancy despite optimal use of currently available treatments. In this preclinical study of novel CTCL therapy, we performed in vitro and ex vivo experiments to determine the efficacy ...
Lei Zhao, Jean-Phillip Okhovat, Eric K. Hong, Youn H. Kim, Gary S. Wood   +4 more
doaj   +1 more source

Mitochondria as the Hub of Apoptosis: A Comprehensive Insight From Mitochondria to Interactions With Other Organelles

MedComm, Volume 7, Issue 9, September 2026.
Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan, Jinming Zhao, Rong Wang, Yue Shi, Zaozao Chen, Yixuan Ma, Na Li, Wenqing Duan, Duo Lin, Chunxiang Zhang   +9 more
wiley   +1 more source

Profiling triple-negative breast cancer-specific super-enhancers identifies high-risk mesenchymal development subtype and BETi-Targetable vulnerabilities

Molecular Cancer
Background Super-enhancers (SEs) are critical regulators of tumorigenesis and represent promising targets for bromodomain and extra-terminal domain inhibitors (BETi). However, clinical studies across various solid tumors, including triple-negative breast
Qing-shan Chen, Rui-zhao Cai, Yan Wang, Ge-hao Liang, Kai-ming Zhang, Xiao-Yu Yang, Dong Yang, De-Chang Zhao, Xiao-Feng Zhu, Rong Deng, Jun Tang   +10 more
doaj   +1 more source

Correction of Ineffective Erythropoiesis and Normalization of Iron Homeostasis After Exagamglogene Autotemcel in Transfusion‐Dependent β‐Thalassemia

American Journal of Hematology, Volume 101, Issue 8, Page 1969-1979, August 2026.
ABSTRACT Exagamglogene autotemcel (exa‐cel) is a one‐time, ex vivo, CRISPR‐Cas9 gene edited cell therapy approved for patients with transfusion dependent β‐thalassemia (TDT) aged 12–35 years. In a Phase 3 study (CLIMB THAL‐111), exa‐cel treatment resulted in reactivation of fetal hemoglobin and increases in total hemoglobin, leading to transfusion ...
Sujit Sheth, Selim Corbacioglu, Josu de la Fuente, Mattia Algeri, Joachim Rupprecht, Kevin H. M. Kuo, Ami J. Shah, Peter Lang, Hayley Merkeley, Ben Carpenter, Markus Y. Mapara, Robert I. Liem, Stephan Grupp, Yogi Chopra, Amanda M. Li, Janet L. Kwiatkowski, Melanie Kirby‐Allen, Maria Domenica Cappellini, Antonis Kattamis, Sakellarios Zairis, Tina Liu, William Hobbs, Haydar Frangoul, Franco Locatelli, Roland Meisel, on behalf of the CLIMB THAL‐111 and CLIMB‐131 Study Groups   +25 more
wiley   +1 more source