Results 31 to 40 of about 6,442 (216)
Oncogenesis, 2021 Targeting the epigenome to modulate gene expression programs driving cancer development has emerged as an exciting avenue for therapeutic intervention.
Jack Calder +4 more
doaj +1 more source
Cells, 2022 Atherosclerosis is an important risk factor in the development of cardiovascular diseases. In addition to increased plasma lipid concentrations, irregular/oscillatory shear stress and inflammatory processes trigger atherosclerosis.
Johannes Jarausch +7 more
doaj +1 more source
Cell Reports, 2018 Summary: BRD4 plays a major role in the transcription networks orchestrated by androgen receptor (AR) in castration-resistant prostate cancer (CRPC). Several BET inhibitors (BETi) that displace BRD4 from chromatin are being evaluated in clinical trials ...
Aishwarya Pawar +3 more
doaj +1 more source
Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer
Cell Reports, 2016 Small-molecule BET bromodomain inhibitors (BETis) are actively being pursued in clinical trials for the treatment of a variety of cancers, but the mechanisms of resistance to BETis remain poorly understood.
Alison M. Kurimchak +15 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease with significant mortality and frequent recurrence. Prior efforts to transcriptionally classify HNSCC into groups of varying prognoses have identified four accepted molecular ...
S. Carson Callahan +26 more
doaj +1 more source
Beti Bachao Beti Padhao: A Programme Of “Empowering Daughters For A Bright Future”
International Journal For Multidisciplinary Research, 2023 Beti Bachao Beti Padhao is an awareness program launched by Govt. of India to save the girl child in India from 2015. It aims at ensuring their safety and also to stop the crime against girl child especially female foeticide and gender inequality in society and educate girls.
openaire +1 more source
Nature Communications, 2020 The clinical use of BET inhibitors (BETi) is limited by primary and acquired resistance. Here, the authors report that BETi resistance is determined by JunD/RSK3 signalling activation induced by the loss of BRD4/Foxd3/miR-548d-3p, which can be reverted ...
Fang Tai +4 more
doaj +1 more source
The Journal of Clinical Investigation, 2022 Latency reversal strategies for HIV cure using inhibitor of apoptosis protein (IAP) antagonists (IAPi) induce unprecedented levels of latent reservoir expression without immunotoxicity during suppressive antiretroviral therapy (ART).
Shane D. Falcinelli +30 more
doaj +1 more source
People and Nature, EarlyView.Abstract Overexploitation of wildlife is pervasive in many tropical regions, and in addition to being a significant conservation and sustainability concern, it has received global attention given discussions over the origins of zoonotic disease outbreaks.
Franklin T. Simo +8 more
wiley +1 more source