Results 21 to 30 of about 6,442 (216)

BETi enhance ATGL expression and its lipase activity to exert their antitumoral effects in triple-negative breast cancer (TNBC) cells

Journal of Experimental & Clinical Cancer Research, 2023
Background Triple-Negative Breast Cancer (TNBC) is a subtype of breast cancer that differs from other types of breast cancers in the faster spread and worse outcome. TNBC presented limited treatment options.
Teresa Rossi, Raffaella Zamponi, Mattea Chirico, Maria Elena Pisanu, Egidio Iorio, Federica Torricelli, Mila Gugnoni, Alessia Ciarrocchi, Mariaelena Pistoni   +8 more
doaj   +1 more source

BET in hematologic tumors: Immunity, pathogenesis, clinical trials and drug combinations

Genes and Diseases, 2023
The bromodomain and extra-terminal (BET) proteins act as “readers” for lysine acetylation and facilitate the recruitment of transcriptional elongation complexes.
Tao Ma, Yan Chen, Zhi-Gang Yi, Yan-Hong Li, Jun Bai, Li-Juan Li, Lian-Sheng Zhang   +6 more
doaj   +1 more source

BET protein inhibition sensitizes glioblastoma cells to temozolomide treatment by attenuating MGMT expression

Cell Death and Disease, 2022
Bromodomain and extra-terminal tail (BET) proteins have been identified as potential epigenetic targets in cancer, including glioblastoma. These epigenetic modifiers link the histone code to gene transcription that can be disrupted with small molecule ...
Alessandro Tancredi, Olga Gusyatiner, Pierre Bady, Michelle C. Buri, Rémy Lomazzi, Davide Chiesi, Mahmoud Messerer, Monika E. Hegi   +7 more
doaj   +1 more source

The BET Inhibitor JQ1 Potentiates the Anticlonogenic Effect of Radiation in Pancreatic Cancer Cells

Frontiers in Oncology, 2022
We reported previously that the BET inhibitor (BETi) JQ1 decreases levels of the DNA repair protein RAD51 and that this decrease is concomitant with increased levels of DNA damage.
Patrick L. Garcia, Aubrey L. Miller, Ling Zeng, Ling Zeng, Robert C. A. M. van Waardenburg, Eddy S. Yang, Eddy S. Yang, Eddy S. Yang, Karina J. Yoon   +8 more
doaj   +1 more source

Highly effective combination of BRG1/BRM inhibitor with BET inhibitor or decitabine for high-risk MECOM-rearranged AML. [PDF]

Hemasphere
Abstract In AML with 3q26.2 rearrangements (r) the distal GATA2 hematopoietic enhancer becomes aberrantly relocated leading to activation of EVI1 expression. EVI1 is a transcriptional regulator that plays a role in proliferation and maintenance of a stem cell‐like phenotype in AML.
Fiskus W, Mill CP, Piel J, Collins M, Hentemann M, Cuglievan B, Birdwell CE, Das K, Davis JA, Hou H, Jain A, Malovannaya A, Flores LB, Kadia TM, Daver N, Sasaki K, Takahashi K, Hammond D, Wang J, Loghavi S, Su X, DiNardo CD, Delwel R, Bhalla KN.   +23 more
europepmc   +2 more sources

Study the properties of a chickpea-based jelly product [PDF]

E3S Web of Conferences, 2021
The consumption of food products with low consumer properties is the reason for a decrease in a life quality as well as for a number of diseases development among the population.
Molchanova Elena, Shipareva Marya, Evmeshkina Tatyana, Isabayev Ismoil   +3 more
doaj   +1 more source

Nurbaiti, Beti. Buku Ajar : Pengolahan Data Dengan Lisrel ISBN : 978-623-315-078-1 Penerbit CV. Pena Persada [PDF]

, 2021
Assalamualaikum Wr Wb Alhamdulilah, segala puji syukur saya haturkan sebagai penulis, karena dengan limpahan Allah SWT, karena berkat Rahmat dan RidhoNya, buku ini dapat selesai disusun dengan melewati berbagai rintangan dan proses penyusunannya yang ...
Nurbaiti, beti
core  

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

Cell Reports, 2017
Summary: BET inhibitors (BETi) target bromodomain-containing proteins and are currently being evaluated as anti-cancer agents. We find that maximal therapeutic effects of BETi in a Myc-driven B cell lymphoma model required an intact host immune system ...
Simon J. Hogg, Stephin J. Vervoort, Sumit Deswal, Christopher J. Ott, Jason Li, Leonie A. Cluse, Paul A. Beavis, Phillip K. Darcy, Benjamin P. Martin, Andrew Spencer, Anna K. Traunbauer, Irina Sadovnik, Karin Bauer, Peter Valent, James E. Bradner, Johannes Zuber, Jake Shortt, Ricky W. Johnstone   +17 more
doaj   +1 more source

The Sinorhizobium meliloti Glycine Betaine Biosynthetic Genes (betICBA) Are Induced by Choline and Highly Expressed in Bacteroids

Molecular Plant-Microbe Interactions, 2003
The symbiotic soil bacterium Sinorhizobium meliloti has the capacity to synthesize the osmoprotectant glycine betaine from choline-O-sulfate and choline.
Karine Mandon, Magne Østerås, Eric Boncompagni, Jean Charles Trinchant, Guillaume Spennato, Marie Christine Poggi, Daniel Le Rudulier   +6 more
doaj   +1 more source

PERSEPSI MASYARAKAT TERHADAP KONTEN YOUTUBE ARIF MUHAMMAD ‘MAK BETI’ [PDF]

, 2023
Tujuan dalam penelitian ini merupakan buat mengenali data serta memperoleh informasi tentang Persepsi Masyarakat Terhadap Konten Youtube Arif Muhammad ‘Mak Beti’.
Arifana, Arifana -
core   +1 more source