Results 1 to 10 of about 7,885 (162)
BRD2 upregulation as a pan-cancer adaptive resistance mechanism to BET inhibition [PDF]
Cellular & Molecular Biology LettersBromodomain and extraterminal motif (BET) inhibitors, such as JQ1, are promising cancer therapeutics that target epigenetic regulators, particularly BRD4.
Suyakarn Archasappawat +3 more
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Combining BET inhibition with SMAC mimetics restricts tumor growth and triggers immune surveillance in preclinical cancer models [PDF]
Cell Reports MedicineSummary: Second mitochondrial activator of caspase (SMAC) mimetics (SMACm) and bromodomain and extra-terminal domain (BET) inhibitors (BETi) are two distinct classes of novel anticancer therapeutics.
Ksenija Slavic Obradovic +24 more
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Bromodomain and extra-terminal protein inhibitors modulate natural killer cell function and differentiation [PDF]
Scientific ReportsNatural killer (NK) cells are integral to the innate immune system, playing a crucial role in immune surveillance and the rapid response to virally infected and tumor cells.
Eric S. Geanes +9 more
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BET inhibitors reduce tumor growth in preclinical models of gastrointestinal gene signature–positive castration-resistant prostate cancer [PDF]
The Journal of Clinical InvestigationA subgroup (~20%–30%) of castration-resistant prostate cancer (CRPC) aberrantly expresses a gastrointestinal (GI) transcriptome governed by 2 GI-lineage-restricted transcription factors, HNF1A and HNF4G.
Shipra Shukla +20 more
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Biomedicines, 2021 BET inhibitors (BETi) including OTX015 (MK-8628) and JQ1 demonstrated antileukemic activity including NPM1c AML cells. Nevertheless, the biological consequences of BETi in NPM1c AML were not fully investigated.
Hanane Djamai +18 more
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Bir Aşk Söyleminden Parçalar Işığında Türk Hikayelerine Kısa Bir Bakış
Mukaddime, 2023 Çalışmamız Roland Barthes’in “Bir Aşk Söyleminden Parçalar” adlı metni temelinde Türk hikayelerinin kısa bir değerlendirmesidir. Barthes’in rastlantısal ve düzenli okumalar tekniği kullanılarak yapılan incelemede toplam yirmi yedi başlık tespit edilmiş ...
Serdal Kara
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Oxygen reduction reaction on platinum single-crystal electrodes modified with protonic ionic liquid
Electrochemistry Communications, 2022 The oxygen reduction reaction (ORR) on the low- and high-index planes of Pt modified with a protonic ionic liquid ([7-methyl-1,5,7-triazabicyclo(4.4.0)dec-5-ene][bis(pentafluoroethylsulfonyl)imide], referred to here as [MTBD][beti]) was studied in 0.1 M ...
Rui Suzuki +2 more
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Journal of Market Access & Health Policy, 2021 Background Standard of care (SoC) for transfusion-dependent β-thalassemia (TDT) requires lifelong, regular blood transfusions as well as chelation to reduce iron accumulation.
Anuraag R. Kansal +9 more
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Pharmaceuticals, 2023 Background: There have been significant advancements in melanoma therapies. BET inhibitors (BETis) show promise in impairing melanoma growth. However, identifying BETi-sensitive melanoma subtypes is challenging.
Liuying Wang +5 more
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Targeting radioresistance and replication fork stability in prostate cancer
JCI Insight, 2022 The bromodomain and extraterminal (BET) family of chromatin reader proteins bind to acetylated histones and regulate gene expression. The development of BET inhibitors (BETi) has expanded our knowledge of BET protein function beyond transcriptional ...
Xiangyi Li +16 more
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