Results 21 to 30 of about 28,983 (181)

Study the properties of a chickpea-based jelly product [PDF]

open access: yesE3S Web of Conferences, 2021
The consumption of food products with low consumer properties is the reason for a decrease in a life quality as well as for a number of diseases development among the population.
Molchanova Elena   +3 more
doaj   +1 more source

BET protein inhibition sensitizes glioblastoma cells to temozolomide treatment by attenuating MGMT expression

open access: yesCell Death and Disease, 2022
Bromodomain and extra-terminal tail (BET) proteins have been identified as potential epigenetic targets in cancer, including glioblastoma. These epigenetic modifiers link the histone code to gene transcription that can be disrupted with small molecule ...
Alessandro Tancredi   +7 more
doaj   +1 more source

Ultrafast and nonlinear spectroscopy of brilliant green-based nanoGUMBOS with enhanced near-infrared emission [PDF]

open access: yes, 2017
The synthesis, characterization, ultrafast dynamics, and nonlinear spectroscopy of 30 nm nanospheres of brilliant green–bis(pentafluoroethylsulfonyl)imide ([BG][BETI]) in water are reported.
Ezzir, Abdulrahman F.   +5 more
core   +2 more sources

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

open access: yesCell Reports, 2017
Summary: BET inhibitors (BETi) target bromodomain-containing proteins and are currently being evaluated as anti-cancer agents. We find that maximal therapeutic effects of BETi in a Myc-driven B cell lymphoma model required an intact host immune system ...
Simon J. Hogg   +17 more
doaj   +1 more source

The Sinorhizobium meliloti Glycine Betaine Biosynthetic Genes (betICBA) Are Induced by Choline and Highly Expressed in Bacteroids

open access: yesMolecular Plant-Microbe Interactions, 2003
The symbiotic soil bacterium Sinorhizobium meliloti has the capacity to synthesize the osmoprotectant glycine betaine from choline-O-sulfate and choline.
Karine Mandon   +6 more
doaj   +1 more source

Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells. role of cMYC-IRF4-miR-125b interplay [PDF]

open access: yes, 2016
Background: Anticancer immune responses may contribute to the control of tumors after conventional chemotherapy and different observations have indicated that chemotherapeutic agents can induce immune responses resulting in cancer cell death and immune ...
Abruzzese, MARIA PIA   +13 more
core   +13 more sources

Resistance to BET inhibitors in lung adenocarcinoma is mediated by casein kinase phosphorylation of BRD4

open access: yesOncogenesis, 2021
Targeting the epigenome to modulate gene expression programs driving cancer development has emerged as an exciting avenue for therapeutic intervention.
Jack Calder   +4 more
doaj   +1 more source

Influence of Shear Stress, Inflammation and BRD4 Inhibition on Human Endothelial Cells: A Holistic Proteomic Approach

open access: yesCells, 2022
Atherosclerosis is an important risk factor in the development of cardiovascular diseases. In addition to increased plasma lipid concentrations, irregular/oscillatory shear stress and inflammatory processes trigger atherosclerosis.
Johannes Jarausch   +7 more
doaj   +1 more source

Application of Small Epigenetic Modulators in Pediatric Medulloblastoma [PDF]

open access: yes, 2018
Medulloblastoma is one of the most frequent among pediatric brain tumors, and it has been classified in various subgroups. Some of them already benefit from quite good therapeutic options, whereas others urgently need novel therapeutic approaches ...
Annalisa Romanelli   +8 more
core   +2 more sources

Effect of shear stress on Pseudomonas aeruginosa isolated from the cystic fibrosis lung [PDF]

open access: yes, 2016
Chronic colonization of the lungs by Pseudomonas aeruginosa is one of the major causes of morbidity and mortality in cystic fibrosis (CF) patients. To gain insights into the characteristic biofilm phenotype of P. aeruginosa in the CF lungs, mimicking the
Cornelis, Pierre   +7 more
core   +3 more sources

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