Results 21 to 30 of about 29,488 (242)
Neoplasia: An International Journal for Oncology Research, 2021 Amplification of MYCN is a poor prognostic feature in neuroblastoma (NBL) indicating aggressive disease. We and others have shown BET bromodomain inhibitors (BETi) target MYCN indirectly by downregulating its transcription.
Joanna S. Yi +16 more
doaj +1 more source
Assessing the Feasibility and Acceptability of a Bespoke Large Language Model Pipeline to Extract Data From Different Study Designs for Public Health Evidence Reviews. [PDF]
Cochrane Evid Synth MethodsABSTRACT Introduction Data extraction is a critical but resource‐intensive step of the evidence review process. Whilst there is evidence that artificial intelligence (AI) and large language models (LLMs) can improve the efficiency of data extraction from randomized controlled trials, their potential for other study designs is unclear.
Simmons Z +7 more
europepmc +2 more sources
Molecular Therapy: Nucleic Acids, 2021 Neuroblastoma (NB) harboring MYCN amplification is a refractory disease with a poor prognosis. As BRD4, an epigenetic reader belonging to the bromodomain and extra terminal domain (BET) family, drives transcription of MYCN in NB cells, BET inhibitors ...
Chang Liu +5 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2023 Background Triple-Negative Breast Cancer (TNBC) is a subtype of breast cancer that differs from other types of breast cancers in the faster spread and worse outcome. TNBC presented limited treatment options.
Teresa Rossi +8 more
doaj +1 more source
BET in hematologic tumors: Immunity, pathogenesis, clinical trials and drug combinations
Genes and Diseases, 2023 The bromodomain and extra-terminal (BET) proteins act as “readers” for lysine acetylation and facilitate the recruitment of transcriptional elongation complexes.
Tao Ma +6 more
doaj +1 more source
The BET Inhibitor JQ1 Potentiates the Anticlonogenic Effect of Radiation in Pancreatic Cancer Cells
Frontiers in Oncology, 2022 We reported previously that the BET inhibitor (BETi) JQ1 decreases levels of the DNA repair protein RAD51 and that this decrease is concomitant with increased levels of DNA damage.
Patrick L. Garcia +8 more
doaj +1 more source
Study the properties of a chickpea-based jelly product [PDF]
E3S Web of Conferences, 2021 The consumption of food products with low consumer properties is the reason for a decrease in a life quality as well as for a number of diseases development among the population.
Molchanova Elena +3 more
doaj +1 more source
EBioMedicine, 2019 Background: Bromodomain and extra-terminal inhibitors (BETi) have shown efficacy for the treatment of aggressive triple negative breast cancer (TNBC).
Sushmita Mustafi +11 more
doaj +1 more source
Cell Death and Disease, 2022 Bromodomain and extra-terminal tail (BET) proteins have been identified as potential epigenetic targets in cancer, including glioblastoma. These epigenetic modifiers link the histone code to gene transcription that can be disrupted with small molecule ...
Alessandro Tancredi +7 more
doaj +1 more source
Ultrafast and nonlinear spectroscopy of brilliant green-based nanoGUMBOS with enhanced near-infrared emission [PDF]
, 2017 The synthesis, characterization, ultrafast dynamics, and nonlinear spectroscopy of 30 nm nanospheres of brilliant green–bis(pentafluoroethylsulfonyl)imide ([BG][BETI]) in water are reported.
Ezzir, Abdulrahman F. +5 more
core +2 more sources