Results 31 to 40 of about 28,983 (181)
Cell Reports, 2018 Summary: BRD4 plays a major role in the transcription networks orchestrated by androgen receptor (AR) in castration-resistant prostate cancer (CRPC). Several BET inhibitors (BETi) that displace BRD4 from chromatin are being evaluated in clinical trials ...
Aishwarya Pawar +3 more
doaj +1 more source
Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer
Cell Reports, 2016 Small-molecule BET bromodomain inhibitors (BETis) are actively being pursued in clinical trials for the treatment of a variety of cancers, but the mechanisms of resistance to BETis remain poorly understood.
Alison M. Kurimchak +15 more
doaj +1 more source
The chronic myeloid leukemia stem cell: stemming the tide of persistence [PDF]
, 2017 Chronic myeloid leukaemia (CML) is caused by the acquisition of the tyrosine kinase BCR-ABL1 in a haemopoietic stem cell (HSC), transforming it into a leukaemic stem cell (LSC) that self-renews, proliferates and differentiates to give rise to a ...
Holyoake, Tessa L., Vetrie, David
core +1 more source
Frontiers in Cell and Developmental Biology, 2022 Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease with significant mortality and frequent recurrence. Prior efforts to transcriptionally classify HNSCC into groups of varying prognoses have identified four accepted molecular ...
S. Carson Callahan +26 more
doaj +1 more source
Nature Communications, 2020 The clinical use of BET inhibitors (BETi) is limited by primary and acquired resistance. Here, the authors report that BETi resistance is determined by JunD/RSK3 signalling activation induced by the loss of BRD4/Foxd3/miR-548d-3p, which can be reverted ...
Fang Tai +4 more
doaj +1 more source
Benefit of Apabetalone on Plasma Proteins in Renal Disease. [PDF]
, 2018 Introduction:Apabetalone, a small molecule inhibitor, targets epigenetic readers termed BET proteins that contribute to gene dysregulation in human disorders. Apabetalone has in vitro and in vivo anti-inflammatory and antiatherosclerotic properties.
Gilham, Dean +11 more
core +2 more sources
The Journal of Clinical Investigation, 2022 Latency reversal strategies for HIV cure using inhibitor of apoptosis protein (IAP) antagonists (IAPi) induce unprecedented levels of latent reservoir expression without immunotoxicity during suppressive antiretroviral therapy (ART).
Shane D. Falcinelli +30 more
doaj +1 more source
The economic position of Beti widows, past and present [PDF]
, 1979 African Studies Center Working Paper No ...
Guyer, Jane I.
core
Women's work in the economy of the Cocoa belt: a comparison [PDF]
, 1978 African Studies Center Working Paper No. 7This paper is an empirical study of the cultural context and historical development of the division of labor by sex in two farming systems of the West African cocoa belt: the Yoruba of Western Nigeria and the ...
Guyer, Jane I.
core
Household budgets and women's incomes [PDF]
, 1980 African Studies Center Working Paper No. 28While explaining proposed studies of aspects of "household economics" to prospective informants in two different African societies, I have been advised very quickly that "Among us, a man and his wife do not ...
Guyer, Jane I.
core