Results 41 to 50 of about 29,488 (242)

The chronic myeloid leukemia stem cell: stemming the tide of persistence [PDF]

open access: yes, 2017
Chronic myeloid leukaemia (CML) is caused by the acquisition of the tyrosine kinase BCR-ABL1 in a haemopoietic stem cell (HSC), transforming it into a leukaemic stem cell (LSC) that self-renews, proliferates and differentiates to give rise to a ...
Holyoake, Tessa L., Vetrie, David
core   +1 more source

High enhancer activity is an epigenetic feature of HPV negative atypical head and neck squamous cell carcinoma

open access: yesFrontiers in Cell and Developmental Biology, 2022
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease with significant mortality and frequent recurrence. Prior efforts to transcriptionally classify HNSCC into groups of varying prognoses have identified four accepted molecular ...
S. Carson Callahan   +26 more
doaj   +1 more source

Enhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance

open access: yesNature Communications, 2020
The clinical use of BET inhibitors (BETi) is limited by primary and acquired resistance. Here, the authors report that BETi resistance is determined by JunD/RSK3 signalling activation induced by the loss of BRD4/Foxd3/miR-548d-3p, which can be reverted ...
Fang Tai   +4 more
doaj   +1 more source

Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo

open access: yesThe Journal of Clinical Investigation, 2022
Latency reversal strategies for HIV cure using inhibitor of apoptosis protein (IAP) antagonists (IAPi) induce unprecedented levels of latent reservoir expression without immunotoxicity during suppressive antiretroviral therapy (ART).
Shane D. Falcinelli   +30 more
doaj   +1 more source

Women's work in the economy of the Cocoa belt: a comparison [PDF]

open access: yes, 1978
African Studies Center Working Paper No. 7This paper is an empirical study of the cultural context and historical development of the division of labor by sex in two farming systems of the West African cocoa belt: the Yoruba of Western Nigeria and the ...
Guyer, Jane I.
core  

Benefit of Apabetalone on Plasma Proteins in Renal Disease. [PDF]

open access: yes, 2018
Introduction:Apabetalone, a small molecule inhibitor, targets epigenetic readers termed BET proteins that contribute to gene dysregulation in human disorders. Apabetalone has in vitro and in vivo anti-inflammatory and antiatherosclerotic properties.
Gilham, Dean   +11 more
core   +2 more sources

Urban wild meat and pangolin consumption across southern forested Cameroon: The limited influence of COVID‐19

open access: yesPeople and Nature, EarlyView.
Abstract Overexploitation of wildlife is pervasive in many tropical regions, and in addition to being a significant conservation and sustainability concern, it has received global attention given discussions over the origins of zoonotic disease outbreaks.
Franklin T. Simo   +8 more
wiley   +1 more source

The economic position of Beti widows, past and present [PDF]

open access: yes, 1979
African Studies Center Working Paper No ...
Guyer, Jane I.
core  

Romance Loans in Middle Dutch and Middle English: Retained or Lost? A Matter of Metre1

open access: yesTransactions of the Philological Society, EarlyView.
Abstract Romance words have been borrowed into all medieval West‐Germanic languages. Modern cognates show that the metrical patterns of loans can differ although the Germanic words remain constant: loan words Dutch kolónie, English cólony, German Koloníe compared with Germanic words Dutch wéduwe, English wídow, German Wítwe.
Johanneke Sytsema, Aditi Lahiri
wiley   +1 more source

Home - About - Disclaimer - Privacy