Results 101 to 110 of about 136,011 (340)

Advantages of Tyrosine Kinase Anti-Angiogenic Cediranib over Bevacizumab: Cell Cycle Abrogation and Synergy with Chemotherapy

Pharmaceuticals, 2021
Angiogenesis plays a crucial role in tumor development and metastasis. Both bevacizumab and cediranib have demonstrated activity as single anti-angiogenic agents in endometrial cancer, though subsequent studies of bevacizumab combined with chemotherapy ...
Jianling Bi, Garima Dixit, Yuping Zhang, Eric J. Devor, Haley A. Losh, Andreea M. Newtson, Kristen L. Coleman, Donna A. Santillan, Thorsten Maretzky, Kristina W. Thiel, Kimberly K. Leslie   +10 more
doaj   +1 more source

Segmentation of diagnostic tissue compartments on whole slide images with renal thrombotic microangiopathies (TMAs) [PDF]

arXiv, 2023
The thrombotic microangiopathies (TMAs) manifest in renal biopsy histology with a broad spectrum of acute and chronic findings. Precise diagnostic criteria for a renal biopsy diagnosis of TMA are missing. As a first step towards a machine learning- and computer vision-based analysis of wholes slide images from renal biopsies, we trained a segmentation ...
arxiv  

Epirubicin With Cyclophosphamide Followed by Docetaxel With Trastuzumab and Bevacizumab as Neoadjuvant Therapy for HER2-Positive Locally Advanced Breast Cancer or as Adjuvant Therapy for HER2-Positive Pathologic Stage III Breast Cancer: A Phase II Trial of the NSABP Foundation Research Group, FB-5 [PDF]

, 2017
Background The purpose of this study was to determine the cardiac safety and clinical activity of trastuzumab and bevacizumab with docetaxel after epirubicin with cyclophosphamide (EC) in patients with HER2-positive locally advanced breast cancer (LABC ...
Ansari, Bilal, Buyse, Marc E., Conlin, Alison K., Geyer, Charles E., Jr., Gross, Howard M., Jacobs, Samuel A., Keogh, George P., Lord, Raymond S., Mamounas, Eleftherios P., Mauquoi, Celine, Patocskai, Erica J., Polikoff, Jonathan A., Rastogi, Priya, Robidoux, André, Smith, John W., Stella, Philip J., Swain, Sandra M., Wolmark, Norman   +17 more
core   +2 more sources

Randomized Phase II and Biomarker Study of Pembrolizumab plus Bevacizumab versus Pembrolizumab Alone for Patients with Recurrent Glioblastoma

Clinical Cancer Research, 2020
Purpose: VEGF is upregulated in glioblastoma and may contribute to immunosuppression. We performed a phase II study of pembrolizumab alone or with bevacizumab in recurrent glioblastoma.
L. Nayak, A. Molinaro, K. Peters, Jennifer L. Clarke, J. Jordan, J. D. de Groot, L. Nghiemphu, T. Kaley, H. Colman, Christine McCluskey, Sarah C. Gaffey, T. Smith, D. Cote, Mariano Severgnini, J. Yearley, Qing Zhao, W. Blumenschein, D. Duda, A. Muzikansky, R. Jain, P. Wen, D. Reardon   +21 more
semanticscholar   +1 more source

Flow‐Induced Vascular Remodeling on‐Chip: Implications for Anti‐VEGF Therapy

Advanced Functional Materials, EarlyView.
Flow‐induced vascular remodeling plays a critical role in network stabilization and function. Using a vasculature‐on‐chip system, this study reveals how physiological VEGF levels and flow affect vascular remodeling and provides insights into tumor vessel normalization.
Fatemeh Mirzapour‐Shafiyi, Elias Huber, Leonie Karr, Johnny Tong, Andreas Richard Bausch, Friedrich Christian Simmel, Karen Alim   +6 more
wiley   +1 more source

Bayesian forecasting of tumor size metrics and overall survival

CPT: Pharmacometrics &Systems Pharmacology, Volume 11, Issue 12, Page 1604-1613, December 2022., 2022
Abstract The tumor size ratio (TSR), time‐to‐tumor growth (TTG), and tumor growth rate (kG) are frequently suggested as model‐based predictors of overall survival (OS) for different types of tumors. When the tumor metrics are applied in forecasting of the outcome for individual patients at an early stage, the tumor data might be sparse resulting in ...
Sreenath M. Krishnan, Lena E. Friberg
wiley   +1 more source

Bevacizumab‐associated intestinal perforation and perioperative complications in patients receiving bevacizumab

Annals of Gastroenterological Surgery, 2020
Aim The purposes of this study are to present cases of emergency surgery in which gastrointestinal perforation occurred during bevacizumab administration, consider the indications for emergency surgery, and examine the safety of scheduled surgery after a
Toshiaki Yoshimoto, Kozo Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yukako Takehara, Mitsuo Shimada   +9 more
doaj   +1 more source

Forced Degradation Testing as Complementary Tool for Biosimilarity Assessment [PDF]

, 2019
Oxidation of monoclonal antibodies (mAbs) can impact their efficacy and may therefore represent critical quality attributes (CQA) that require evaluation.
Dyck, Yan Felix Karl, Jabs, Wolfgang, Joseph, Jan Felix, Parr, Maria Kristina, Rehm, Daniel, Sandig, Volker, Winkler, Karsten   +6 more
core   +1 more source

Bevacizumab for Malignant Gliomas [PDF]

Archives of Neurology, 2010
Malignant gliomas are the most common and aggressive primary brain tumors in adults. Despite optimal treatment with surgery, radiotherapy, and temozolomide, tumor recurrences are frequent and patients with malignant gliomas continue to have poor prognoses.
Fabio M. Iwamoto, Howard A. Fine
openaire   +3 more sources

Microneedles with Interdigitated Electrodes for In Situ Impedimetric VEGF Sensing

Advanced Materials Interfaces, EarlyView.
An electrochemical device for transdermal monitoring based on flexible polylactide microneedles with interdigitated electrodes enables continuous monitoring of vascular endothelial growth factor (VEGF) in interstitial fluid. Gold‐coated microneedles functionalized with anti‐VEGF antibodies, provide an in situ detection platform with high sensitivity ...
Ritu Das, Emin Istif, Rumeysa Cebecioglu, Mohsin Ali, Yasin Atik, Çağdaş Dağ, Eda Celikbas, Gozde Demirci, FundaYagcı Acar, Murat Hasanreisoğlu, Levent Beker   +10 more
wiley   +1 more source