Results 121 to 130 of about 85,257 (242)

Heart failure medication to prevent cancer therapy–related cardiac dysfunction: A narrative review

British Journal of Pharmacology, EarlyView.
Advances in oncological therapies have improved cancer survival but also have increased the clinical incidence of cancer therapy–related cardiac dysfunction (CTRCD), a spectrum of conditions ranging from subclinical biomarker or strain abnormalities to progressive heart failure and cardiogenic shock.
Fabian Voß, Paul Goerke, Malte Kelm, Amin Polzin   +3 more
wiley   +1 more source

Systemic Inflammation Modifies the Efficacy of Bevacizumab Added to Atezolizumab Plus Chemotherapy for Advanced Non-Squamous Non-Small Cell Lung Cancer: A Multicenter Retrospective Study. [PDF]

Thorac Cancer
Yamauchi K, Matsumoto K, Shiroyama T, Tamiya A, Tamiya M, Tsukaguchi A, Miyazaki A, Komuta K, Mihashi Y, Machiyama H, Kanaoka K, Kuge T, Kinehara Y, Shoshihara N, Niki T, Kato S, Nishikawa Y, Azuma K, Tanaka S, Osa A, Suzuki H, Nagatomo I, Uchida J, Takeda Y, Kumanogoh A.   +24 more
europepmc   +1 more source

A Melanoma Transplanted in Nude Mice Has Both Host‐ and Tumor‐Derived Blood Vessel‐ and Nerve‐Like Structures

Cancer Science, EarlyView.
Nestin‐driven green fluorescent protein (ND‐GFP) expressing peripheral blood vessels and nerves in the subcutaneous tissue of the ND‐GFP mice extended into the transplanted melanoma such that ND‐GFP was enhanced at the margin of the melanoma compared to the tumor‐free side.
Koya Obara, Azusa Sasaki, Yuko Hamada, Yutaro Kubota, Yusuke Aoki, Noriyuki Masaki, Michael Bouvet, Yasuyuki Amoh, Robert M. Hoffman   +8 more
wiley   +1 more source

Indole‐3‐Propionic Acid Drives Dendritic H3K27 Acetylation to Enhance CD8+ T Cell Immunity in Hepatocellular Carcinoma

Cancer Science, EarlyView.
The gut microbiota metabolite indole ‐ 3 ‐ propionic acid（IPA) enhanced the inhibitory effect of SCB on tumor growth in HCC mice. IPA upregulated IL‐12A expression through facilitating acetylation of H3K27 in DCs. IPA elevated IL‐12A expression in DCs to promote CD8+ T cell anti‐tumor immunity and ultimately enhances the efficacy of SCB therapy against
Rui Zhao, Siqi Liu, Qian Zhang, Wenrui Wang, Lanlan Yang, Xue Shao, Shengnan Jia, Zhenjing Jin   +7 more
wiley   +1 more source

Pragmatic health technology appraisals of biosimilars: a pilot case study of bevacizumab in colorectal cancer for NICE. [PDF]

Cost Eff Resour Alloc
Stevenson MD, Mon-Yee M, Forsyth JE, Montazeri A, Saunders MP.   +4 more
europepmc   +1 more source

Genomic Evolution and Immune Contexture With Therapeutic Relevance in Pancreatic Neuroendocrine Neoplasms

Cancer Science, EarlyView.
Lineage‐dependent immunogenomic landscapes and biologically informed therapy in pancreatic neuroendocrine neoplasms. Pancreatic neuroendocrine neoplasms display lineage‐dependent immunogenomic landscapes, in which genomic alterations, epigenetic states, antigen‐presentation status, immune‐cell infiltration, and suppressive microenvironments co‐evolve ...
Yohei Tabe, Eito Nakagawa, Daisuke Asano, Eriko Katsuta, Daisuke Ban, Shogo Kumagai   +5 more
wiley   +1 more source

Hematological toxicities in bevacizumab associated with ovarian cancer: A pharmacovigilance study using FDA adverse event reporting system database. [PDF]

Medicine (Baltimore)
Zhou X, Su L, Lin Y, Cheng Z, Du Z, Han B, Wang X.   +6 more
europepmc   +1 more source

MEN1 Deficiency Drives Lung Cancer Progression via Activation of MMP10‐Mediated Angiogenesis

Cancer Science, EarlyView.
MEN1 deficiency promotes JunD‐mediated upregulation of MMP10 expression, which cleaves pro‐HB‐EGF and activates endothelial EGFR. This triggers the PI3K/Akt and MEK/ERK signaling pathways, thereby driving angiogenesis and tumor progression. MMP10 inhibitor treatment blocks this cleavage, suppresses EGFR signaling, and thereby delays malignant ...
Chengyu Wei, Xiangyu Liu, Shimin Hu, Xiaodie Shen, Yingli Liu, Xinxin Qin, Ye Zhou, Jianqi Zheng, Bingke Tian, Jingfang Hong, Yongxia Song, Di Wang, Linlin Peng, Jinxia Ding, Fang Wang, Hui Zhang, Shihao Zhang, Huan Qiu   +17 more
wiley   +1 more source

Bevacizumab induces apoptosis in glioblastoma cells by upregulating miR-4695-5p to inhibit PKMYT1. [PDF]

RNA Biol
Shen Y, Yang C, Wang H, Hu S, Hao Y, Geng Y, Huang S.   +6 more
europepmc   +1 more source

AI‐Based Analysis of Tumor‐Infiltrating Lymphocytes and Homologous Recombination in Ovarian Cancer: JGOG3025‐A1 Study

Cancer Science, EarlyView.
AI‐based spatial analysis of tumor‐infiltrating lymphocytes in ovarian cancer revealed the highest infiltration in high‐grade serous carcinoma. Integrating pathology‐based immune phenotypes with HRD status provided additional prognostic insight and highlighted distinct relationships between TILs and genomic structure.
Kohei Hamada, Junzo Hamanishi, Noriomi Matsumura, Akihiko Ueda, Shiro Takamatsu, Kosuke Yoshihara, Takayuki Nagasawa, Toshiyuki Seki, Akira Kikuchi, Etsuko Fujimoto, Mana Taki, Koji Yamanoi, Ryusuke Murakami, Hisaaki Kudo, Katsutoshi Oda, Muneaki Shimada, Aikou Okamoto, Masaki Mandai   +17 more
wiley   +1 more source