Results 201 to 210 of about 216,339 (397)

The regulatory effects and applications of TIGIT/CD155 on the tumor microenvironment in HCC

open access: yesVIEW, EarlyView.
Background The interaction between TIGIT and CD155 compromises immune cell efficacy in tumor targeting, potentially driving hepatocellular carcinoma (HCC) progression through diverse molecular pathways. What Was Done This study investigates the interplay between CD155 and TIGIT in regulating CD8+ T cell function and elucidates its implications in HCC ...
Wenting Li   +10 more
wiley   +1 more source

Nanotechnology and cell death: Revolutionizing disease treatment with nanoparticle strategies

open access: yesVIEW, EarlyView.
Traditional disease treatments often face issues such as poor drug targeting and significant side effects, with many complex diseases lacking effective therapies. Our research utilizes tiny nanomaterials to treat diseases by regulating natural cell death processes, improving the immune environment, etc., enabling drugs to act more precisely.
Yiwen Wan   +6 more
wiley   +1 more source

A new clustering: Angiogenesis‐associated molecular classification of lung adenocarcinoma

open access: yesVIEW, EarlyView.
Lung adenocarcinoma (LUAD) is a heterogeneous disease, with varying patient prognosis and challenges in personalized treatments. We identified three LUAD subtypes based on angiogenesis‐related genes in this study, revealing distinct biological features and key survival‐related genes that could serve as targets for personalized therapies.
Lin Zhu   +16 more
wiley   +1 more source

Pharmacokinetics of intravitreal bevacizumab (Avastin®) in rabbits

open access: yesClinical Ophthalmology, 2011
Christos I Sinapis1,*, John G Routsias2,*, Angelos I Sinapis1,*, Dimitrios I Sinapis1,*, George D Agrogiannis3, Alkistis Pantopoulou1, Stamatis E Theocharis4, Stefanos Baltatzis5, Efstratios Patsouris3, Despoina Perrea11Laboratory for Experimental ...
Sinapis C   +9 more
doaj  

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma. [PDF]

open access: yes, 2019
Glioblastoma is the most common primary malignant brain tumor in adults and is associated with poor survival. The Ivy Foundation Early Phase Clinical Trials Consortium conducted a randomized, multi-institution clinical trial to evaluate immune responses ...
Arrillaga-Romany, Isabel C   +29 more
core  

Determining the Survival Impact and Cost‐Effectiveness of Multi‐Gene Panel Sequencing in Metastatic Colorectal Cancer With Super Learning Approaches

open access: yesHealth Services Research, EarlyView.
ABSTRACT Objective To determine the effectiveness and cost‐effectiveness of multi‐gene panel sequencing compared to single‐gene KRAS testing for metastatic colorectal cancer (mCRC). Study Setting and Design British Columbia, Canada (BC) is a provincial single‐payer public healthcare system, and it was the first province to publicly reimburse multi‐gene
Emanuel Krebs   +4 more
wiley   +1 more source

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